| Full name: protocadherin 12 | Alias Symbol: VE-cadherin-2 | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 51294 | HGNC ID: HGNC:8657 | Ensembl Gene: ENSG00000113555 | OMIM ID: 605622 |
| Drug and gene relationship at DGIdb | |||
Expression of PCDH12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCDH12 | 51294 | 219656_at | 0.1751 | 0.6476 | |
| GSE20347 | PCDH12 | 51294 | 219656_at | 0.0986 | 0.3541 | |
| GSE23400 | PCDH12 | 51294 | 219656_at | -0.0559 | 0.1175 | |
| GSE26886 | PCDH12 | 51294 | 219656_at | -0.0648 | 0.6654 | |
| GSE29001 | PCDH12 | 51294 | 219656_at | -0.0386 | 0.8514 | |
| GSE38129 | PCDH12 | 51294 | 219656_at | -0.0417 | 0.7225 | |
| GSE45670 | PCDH12 | 51294 | 219656_at | 0.1125 | 0.3906 | |
| GSE53622 | PCDH12 | 51294 | 17556 | 0.4651 | 0.0001 | |
| GSE53624 | PCDH12 | 51294 | 17556 | 1.0199 | 0.0000 | |
| GSE63941 | PCDH12 | 51294 | 219656_at | 0.2519 | 0.1283 | |
| GSE77861 | PCDH12 | 51294 | 219656_at | 0.0130 | 0.9255 | |
| GSE97050 | PCDH12 | 51294 | A_23_P423309 | 0.2630 | 0.4272 | |
| SRP007169 | PCDH12 | 51294 | RNAseq | 2.3826 | 0.0006 | |
| SRP008496 | PCDH12 | 51294 | RNAseq | 2.6313 | 0.0000 | |
| SRP064894 | PCDH12 | 51294 | RNAseq | 1.8499 | 0.0000 | |
| SRP133303 | PCDH12 | 51294 | RNAseq | 0.1884 | 0.4302 | |
| SRP159526 | PCDH12 | 51294 | RNAseq | 1.1855 | 0.0001 | |
| SRP193095 | PCDH12 | 51294 | RNAseq | 0.8048 | 0.0000 | |
| SRP219564 | PCDH12 | 51294 | RNAseq | 1.1481 | 0.0496 | |
| TCGA | PCDH12 | 51294 | RNAseq | -0.1651 | 0.1639 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PCDH12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCDH12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCDH12 | 51294 | 2 | 11 | 17 | |
| GSE20123 | PCDH12 | 51294 | 2 | 11 | 17 | |
| GSE43470 | PCDH12 | 51294 | 2 | 10 | 31 | |
| GSE46452 | PCDH12 | 51294 | 0 | 27 | 32 | |
| GSE47630 | PCDH12 | 51294 | 0 | 20 | 20 | |
| GSE54993 | PCDH12 | 51294 | 9 | 1 | 60 | |
| GSE54994 | PCDH12 | 51294 | 2 | 14 | 37 | |
| GSE60625 | PCDH12 | 51294 | 0 | 0 | 11 | |
| GSE74703 | PCDH12 | 51294 | 2 | 7 | 27 | |
| GSE74704 | PCDH12 | 51294 | 2 | 5 | 13 | |
| TCGA | PCDH12 | 51294 | 3 | 38 | 55 |
Total number of gains: 24; Total number of losses: 144; Total Number of normals: 320.
Somatic mutations of PCDH12:
Generating mutation plots.
Highly correlated genes for PCDH12:
Showing top 20/413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCDH12 | TERF2 | 0.786032 | 3 | 0 | 3 |
| PCDH12 | ANKRD34A | 0.761764 | 3 | 0 | 3 |
| PCDH12 | BCKDK | 0.742501 | 3 | 0 | 3 |
| PCDH12 | FAM167B | 0.729562 | 4 | 0 | 4 |
| PCDH12 | CDYL2 | 0.70755 | 3 | 0 | 3 |
| PCDH12 | MRM1 | 0.700961 | 4 | 0 | 3 |
| PCDH12 | PRTN3 | 0.691383 | 3 | 0 | 3 |
| PCDH12 | CACNA1B | 0.690956 | 3 | 0 | 3 |
| PCDH12 | TRAM2 | 0.68861 | 5 | 0 | 5 |
| PCDH12 | THOC5 | 0.687605 | 4 | 0 | 3 |
| PCDH12 | IST1 | 0.686091 | 3 | 0 | 3 |
| PCDH12 | LRRC8C | 0.685816 | 3 | 0 | 3 |
| PCDH12 | RAB4B | 0.68473 | 3 | 0 | 3 |
| PCDH12 | JOSD1 | 0.682607 | 4 | 0 | 3 |
| PCDH12 | RAB34 | 0.679415 | 3 | 0 | 3 |
| PCDH12 | LY96 | 0.679263 | 3 | 0 | 3 |
| PCDH12 | RILPL2 | 0.678655 | 4 | 0 | 3 |
| PCDH12 | ST6GALNAC4 | 0.676222 | 4 | 0 | 3 |
| PCDH12 | FEZ1 | 0.666604 | 5 | 0 | 4 |
| PCDH12 | GHDC | 0.66594 | 4 | 0 | 3 |
For details and further investigation, click here
