| Full name: coatomer protein complex subunit zeta 1 | Alias Symbol: CGI-120 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 22818 | HGNC ID: HGNC:2243 | Ensembl Gene: ENSG00000111481 | OMIM ID: 615472 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPZ1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPZ1 | 22818 | 222386_s_at | -0.1408 | 0.8180 | |
| GSE20347 | COPZ1 | 22818 | 217726_at | -0.0093 | 0.9513 | |
| GSE23400 | COPZ1 | 22818 | 217726_at | 0.2329 | 0.0004 | |
| GSE26886 | COPZ1 | 22818 | 217726_at | -0.6140 | 0.0029 | |
| GSE29001 | COPZ1 | 22818 | 217726_at | -0.1827 | 0.6955 | |
| GSE38129 | COPZ1 | 22818 | 217726_at | 0.1471 | 0.2201 | |
| GSE45670 | COPZ1 | 22818 | 222386_s_at | -0.0013 | 0.9944 | |
| GSE53622 | COPZ1 | 22818 | 63240 | 0.0170 | 0.7980 | |
| GSE53624 | COPZ1 | 22818 | 63240 | -0.2852 | 0.0000 | |
| GSE63941 | COPZ1 | 22818 | 222386_s_at | 1.7010 | 0.0004 | |
| GSE77861 | COPZ1 | 22818 | 222386_s_at | -0.5074 | 0.0072 | |
| GSE97050 | COPZ1 | 22818 | A_24_P389959 | 0.1196 | 0.6072 | |
| SRP007169 | COPZ1 | 22818 | RNAseq | -0.9729 | 0.0034 | |
| SRP008496 | COPZ1 | 22818 | RNAseq | -0.7976 | 0.0000 | |
| SRP064894 | COPZ1 | 22818 | RNAseq | -0.0297 | 0.8837 | |
| SRP133303 | COPZ1 | 22818 | RNAseq | 0.2961 | 0.0636 | |
| SRP159526 | COPZ1 | 22818 | RNAseq | -0.0115 | 0.9509 | |
| SRP193095 | COPZ1 | 22818 | RNAseq | -0.2578 | 0.0486 | |
| SRP219564 | COPZ1 | 22818 | RNAseq | -0.0107 | 0.9738 | |
| TCGA | COPZ1 | 22818 | RNAseq | 0.0316 | 0.4617 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COPZ1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPZ1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPZ1 | 22818 | 4 | 1 | 25 | |
| GSE20123 | COPZ1 | 22818 | 4 | 1 | 25 | |
| GSE43470 | COPZ1 | 22818 | 3 | 0 | 40 | |
| GSE46452 | COPZ1 | 22818 | 7 | 1 | 51 | |
| GSE47630 | COPZ1 | 22818 | 10 | 2 | 28 | |
| GSE54993 | COPZ1 | 22818 | 0 | 5 | 65 | |
| GSE54994 | COPZ1 | 22818 | 4 | 1 | 48 | |
| GSE60625 | COPZ1 | 22818 | 0 | 0 | 11 | |
| GSE74703 | COPZ1 | 22818 | 3 | 0 | 33 | |
| GSE74704 | COPZ1 | 22818 | 3 | 1 | 16 | |
| TCGA | COPZ1 | 22818 | 15 | 11 | 70 |
Total number of gains: 53; Total number of losses: 23; Total Number of normals: 412.
Somatic mutations of COPZ1:
Generating mutation plots.
Highly correlated genes for COPZ1:
Showing top 20/830 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPZ1 | NDUFV1 | 0.808984 | 3 | 0 | 3 |
| COPZ1 | COX15 | 0.802917 | 3 | 0 | 3 |
| COPZ1 | CALCOCO2 | 0.789058 | 3 | 0 | 3 |
| COPZ1 | TRIM6 | 0.77599 | 3 | 0 | 3 |
| COPZ1 | GRHPR | 0.767661 | 3 | 0 | 3 |
| COPZ1 | LRMP | 0.750137 | 4 | 0 | 4 |
| COPZ1 | TRAPPC1 | 0.748962 | 3 | 0 | 3 |
| COPZ1 | CXXC5 | 0.73846 | 3 | 0 | 3 |
| COPZ1 | SPRYD4 | 0.735881 | 6 | 0 | 6 |
| COPZ1 | ABLIM2 | 0.735731 | 3 | 0 | 3 |
| COPZ1 | LRBA | 0.735662 | 5 | 0 | 4 |
| COPZ1 | CNOT10 | 0.734044 | 3 | 0 | 3 |
| COPZ1 | FUCA1 | 0.733533 | 4 | 0 | 3 |
| COPZ1 | TYSND1 | 0.732494 | 4 | 0 | 3 |
| COPZ1 | PRMT6 | 0.732436 | 3 | 0 | 3 |
| COPZ1 | TMED4 | 0.731953 | 4 | 0 | 4 |
| COPZ1 | RASSF5 | 0.720265 | 4 | 0 | 4 |
| COPZ1 | DLG3 | 0.719969 | 4 | 0 | 4 |
| COPZ1 | ZNF436 | 0.717214 | 4 | 0 | 4 |
| COPZ1 | RPL19 | 0.71636 | 3 | 0 | 3 |
For details and further investigation, click here
