| Full name: roundabout guidance receptor 4 | Alias Symbol: FLJ20798|MRB|ECSM4 | ||
| Type: protein-coding gene | Cytoband: 11q24.2 | ||
| Entrez ID: 54538 | HGNC ID: HGNC:17985 | Ensembl Gene: ENSG00000154133 | OMIM ID: 607528 |
| Drug and gene relationship at DGIdb | |||
Expression of ROBO4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROBO4 | 54538 | 226028_at | -0.1235 | 0.7963 | |
| GSE20347 | ROBO4 | 54538 | 220758_s_at | -0.0875 | 0.1792 | |
| GSE23400 | ROBO4 | 54538 | 220758_s_at | -0.1940 | 0.0000 | |
| GSE26886 | ROBO4 | 54538 | 226028_at | 0.0406 | 0.8931 | |
| GSE29001 | ROBO4 | 54538 | 220758_s_at | -0.3494 | 0.0136 | |
| GSE38129 | ROBO4 | 54538 | 220758_s_at | -0.2233 | 0.0059 | |
| GSE45670 | ROBO4 | 54538 | 226028_at | -0.2822 | 0.4129 | |
| GSE53622 | ROBO4 | 54538 | 32357 | -0.5647 | 0.0001 | |
| GSE53624 | ROBO4 | 54538 | 32357 | -0.1322 | 0.2480 | |
| GSE63941 | ROBO4 | 54538 | 220758_s_at | 0.0194 | 0.9231 | |
| GSE77861 | ROBO4 | 54538 | 220758_s_at | -0.2270 | 0.1957 | |
| GSE97050 | ROBO4 | 54538 | A_23_P344421 | 0.0096 | 0.9759 | |
| SRP007169 | ROBO4 | 54538 | RNAseq | 0.2763 | 0.6269 | |
| SRP064894 | ROBO4 | 54538 | RNAseq | 0.6826 | 0.0413 | |
| SRP133303 | ROBO4 | 54538 | RNAseq | -0.5946 | 0.0100 | |
| SRP159526 | ROBO4 | 54538 | RNAseq | -0.1078 | 0.7826 | |
| SRP193095 | ROBO4 | 54538 | RNAseq | 0.7706 | 0.0001 | |
| SRP219564 | ROBO4 | 54538 | RNAseq | -0.3234 | 0.4700 | |
| TCGA | ROBO4 | 54538 | RNAseq | -0.4111 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ROBO4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROBO4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROBO4 | 54538 | 0 | 13 | 17 | |
| GSE20123 | ROBO4 | 54538 | 0 | 13 | 17 | |
| GSE43470 | ROBO4 | 54538 | 2 | 7 | 34 | |
| GSE46452 | ROBO4 | 54538 | 3 | 26 | 30 | |
| GSE47630 | ROBO4 | 54538 | 2 | 19 | 19 | |
| GSE54993 | ROBO4 | 54538 | 10 | 0 | 60 | |
| GSE54994 | ROBO4 | 54538 | 5 | 19 | 29 | |
| GSE60625 | ROBO4 | 54538 | 0 | 3 | 8 | |
| GSE74703 | ROBO4 | 54538 | 1 | 5 | 30 | |
| GSE74704 | ROBO4 | 54538 | 0 | 9 | 11 | |
| TCGA | ROBO4 | 54538 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of ROBO4:
Generating mutation plots.
Highly correlated genes for ROBO4:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROBO4 | CISD3 | 0.741411 | 3 | 0 | 3 |
| ROBO4 | RNF31 | 0.724849 | 3 | 0 | 3 |
| ROBO4 | GNGT2 | 0.720787 | 3 | 0 | 3 |
| ROBO4 | SNX1 | 0.717719 | 4 | 0 | 3 |
| ROBO4 | KDR | 0.710145 | 4 | 0 | 4 |
| ROBO4 | PREX1 | 0.709248 | 3 | 0 | 3 |
| ROBO4 | S1PR1 | 0.70835 | 4 | 0 | 4 |
| ROBO4 | DISP2 | 0.707826 | 3 | 0 | 3 |
| ROBO4 | NFAM1 | 0.705201 | 3 | 0 | 3 |
| ROBO4 | RFTN2 | 0.703747 | 3 | 0 | 3 |
| ROBO4 | GIMAP5 | 0.695104 | 3 | 0 | 3 |
| ROBO4 | KCNJ8 | 0.694268 | 5 | 0 | 5 |
| ROBO4 | BCKDK | 0.69217 | 3 | 0 | 3 |
| ROBO4 | CYYR1 | 0.689035 | 5 | 0 | 5 |
| ROBO4 | SMYD1 | 0.686979 | 3 | 0 | 3 |
| ROBO4 | ATF7 | 0.681935 | 5 | 0 | 5 |
| ROBO4 | FIBIN | 0.674776 | 3 | 0 | 3 |
| ROBO4 | TNFSF12 | 0.672937 | 3 | 0 | 3 |
| ROBO4 | ADAMTS5 | 0.671622 | 5 | 0 | 5 |
| ROBO4 | REXO2 | 0.669585 | 3 | 0 | 3 |
For details and further investigation, click here
