| Full name: BRF2 RNA polymerase III transcription initiation factor subunit | Alias Symbol: FLJ11052|BRFU|TFIIIB50 | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 55290 | HGNC ID: HGNC:17298 | Ensembl Gene: ENSG00000104221 | OMIM ID: 607013 |
| Drug and gene relationship at DGIdb | |||
Expression of BRF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRF2 | 55290 | 218955_at | 0.3642 | 0.2422 | |
| GSE20347 | BRF2 | 55290 | 218955_at | 0.5282 | 0.0003 | |
| GSE23400 | BRF2 | 55290 | 218955_at | 0.2233 | 0.0000 | |
| GSE26886 | BRF2 | 55290 | 218955_at | 0.3012 | 0.0227 | |
| GSE29001 | BRF2 | 55290 | 218955_at | 0.3622 | 0.0579 | |
| GSE38129 | BRF2 | 55290 | 218955_at | 0.3627 | 0.0029 | |
| GSE45670 | BRF2 | 55290 | 218955_at | 0.2983 | 0.0657 | |
| GSE63941 | BRF2 | 55290 | 218955_at | -0.4653 | 0.0751 | |
| GSE77861 | BRF2 | 55290 | 218955_at | 0.3167 | 0.2657 | |
| SRP007169 | BRF2 | 55290 | RNAseq | 1.2056 | 0.0045 | |
| SRP008496 | BRF2 | 55290 | RNAseq | 1.3632 | 0.0004 | |
| SRP064894 | BRF2 | 55290 | RNAseq | 0.7628 | 0.0316 | |
| SRP133303 | BRF2 | 55290 | RNAseq | 0.7005 | 0.0000 | |
| SRP159526 | BRF2 | 55290 | RNAseq | 0.4842 | 0.1708 | |
| SRP193095 | BRF2 | 55290 | RNAseq | 0.9854 | 0.0000 | |
| SRP219564 | BRF2 | 55290 | RNAseq | 0.3512 | 0.4470 | |
| TCGA | BRF2 | 55290 | RNAseq | 0.1287 | 0.1384 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by BRF2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BRF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRF2 | 55290 | 8 | 4 | 18 | |
| GSE20123 | BRF2 | 55290 | 9 | 4 | 17 | |
| GSE43470 | BRF2 | 55290 | 7 | 7 | 29 | |
| GSE46452 | BRF2 | 55290 | 20 | 7 | 32 | |
| GSE47630 | BRF2 | 55290 | 12 | 7 | 21 | |
| GSE54993 | BRF2 | 55290 | 2 | 16 | 52 | |
| GSE54994 | BRF2 | 55290 | 16 | 8 | 29 | |
| GSE60625 | BRF2 | 55290 | 3 | 0 | 8 | |
| GSE74703 | BRF2 | 55290 | 7 | 5 | 24 | |
| GSE74704 | BRF2 | 55290 | 7 | 1 | 12 | |
| TCGA | BRF2 | 55290 | 35 | 25 | 36 |
Total number of gains: 126; Total number of losses: 84; Total Number of normals: 278.
Somatic mutations of BRF2:
Generating mutation plots.
Highly correlated genes for BRF2:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRF2 | GPR158 | 0.70967 | 3 | 0 | 3 |
| BRF2 | LSM1 | 0.695621 | 10 | 0 | 9 |
| BRF2 | ASH2L | 0.688444 | 9 | 0 | 8 |
| BRF2 | CCDC113 | 0.687764 | 3 | 0 | 3 |
| BRF2 | BMPR1B | 0.682369 | 3 | 0 | 3 |
| BRF2 | MAGEA11 | 0.682269 | 4 | 0 | 3 |
| BRF2 | TM2D2 | 0.672152 | 5 | 0 | 4 |
| BRF2 | CTAG2 | 0.668658 | 3 | 0 | 3 |
| BRF2 | LAMA2 | 0.664084 | 3 | 0 | 3 |
| BRF2 | ERP29 | 0.662629 | 3 | 0 | 3 |
| BRF2 | IQCK | 0.661812 | 3 | 0 | 3 |
| BRF2 | SIX4 | 0.647962 | 4 | 0 | 3 |
| BRF2 | TMED6 | 0.647645 | 3 | 0 | 3 |
| BRF2 | TM2D1 | 0.643597 | 3 | 0 | 3 |
| BRF2 | XPO7 | 0.638071 | 4 | 0 | 3 |
| BRF2 | FCHSD2 | 0.634415 | 3 | 0 | 3 |
| BRF2 | MORN4 | 0.632533 | 3 | 0 | 3 |
| BRF2 | PELI2 | 0.630948 | 4 | 0 | 3 |
| BRF2 | SYNGR3 | 0.630207 | 3 | 0 | 3 |
| BRF2 | RNF34 | 0.621948 | 3 | 0 | 3 |
For details and further investigation, click here
