Full name: mitogen-activated protein kinase 1	Alias Symbol: ERK|ERK2|p41mapk|MAPK2
Type: protein-coding gene	Cytoband: 22q11.22
Entrez ID: 5594	HGNC ID: HGNC:6871	Ensembl Gene: ENSG00000100030	OMIM ID: 176948
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 31/325 cell lines had fitness change in Project Score. This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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MAPK1 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04012	ErbB signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04150	mTOR signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04210	Apoptosis	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04270	Vascular smooth muscle contraction	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04510	Focal adhesion	View
hsa04520	Adherens junction	View
hsa04540	Gap junction	View
hsa04550	Signaling pathways regulating pluripotency of stem cells	View
hsa04611	Platelet activation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04664	Fc epsilon RI signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04668	TNF signaling pathway	View
hsa04713	Circadian entrainment	View
hsa04720	Long-term potentiation	View
hsa04722	Neurotrophin signaling pathway	View
hsa04723	Retrograde endocannabinoid signaling	View
hsa04724	Glutamatergic synapse	View
hsa04725	Cholinergic synapse	View
hsa04726	Serotonergic synapse	View
hsa04730	Long-term depression	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04910	Insulin signaling pathway	View
hsa04912	GnRH signaling pathway	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04916	Melanogenesis	View
hsa04917	Prolactin signaling pathway	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04930	Type II diabetes mellitus	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05020	Prion diseases	View
hsa05034	Alcoholism	View
hsa05131	Shigellosis	View
hsa05132	Salmonella infection	View
hsa05133	Pertussis	View
hsa05140	Leishmaniasis	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05152	Tuberculosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05164	Influenza A	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05210	Colorectal cancer	View
hsa05211	Renal cell carcinoma	View
hsa05212	Pancreatic cancer	View
hsa05213	Endometrial cancer	View
hsa05214	Glioma	View
hsa05215	Prostate cancer	View
hsa05216	Thyroid cancer	View
hsa05218	Melanoma	View
hsa05219	Bladder cancer	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05223	Non-small cell lung cancer	View
hsa05231	Choline metabolism in cancer	View

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Expression of MAPK1:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	MAPK1	5594	224621_at	-0.0461	0.9153	Show
GSE20347	MAPK1	5594	212271_at	-0.8491	0.0002	Show
GSE23400	MAPK1	5594	212271_at	-0.0402	0.6495	Show
GSE26886	MAPK1	5594	224621_at	-0.6073	0.0006	Show
GSE29001	MAPK1	5594	212271_at	-0.2492	0.3843	Show
GSE38129	MAPK1	5594	212271_at	-0.3245	0.1563	Show
GSE45670	MAPK1	5594	224621_at	-0.1056	0.5245	Show
GSE53622	MAPK1	5594	26011	-0.1540	0.0068	Show
GSE53624	MAPK1	5594	26011	-0.2554	0.0000	Show
GSE63941	MAPK1	5594	224621_at	-0.2167	0.6090	Show
GSE77861	MAPK1	5594	224621_at	0.2158	0.3743	Show
GSE97050	MAPK1	5594	A_23_P257895	-0.0018	0.9936	Show
SRP007169	MAPK1	5594	RNAseq	-0.3645	0.2977	Show
SRP008496	MAPK1	5594	RNAseq	-0.3602	0.0600	Show
SRP064894	MAPK1	5594	RNAseq	-0.1391	0.4551	Show
SRP133303	MAPK1	5594	RNAseq	-0.1154	0.3787	Show
SRP159526	MAPK1	5594	RNAseq	-0.3383	0.2309	Show
SRP193095	MAPK1	5594	RNAseq	-0.1822	0.1139	Show
SRP219564	MAPK1	5594	RNAseq	-0.1693	0.6603	Show
TCGA	MAPK1	5594	RNAseq	-0.1130	0.0041	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by MAPK1 expression:

 

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Copy number change of MAPK1:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	MAPK1	5594	5	7	18	Show
GSE20123	MAPK1	5594	5	7	18	Show
GSE43470	MAPK1	5594	3	7	33	Show
GSE46452	MAPK1	5594	33	1	25	Show
GSE47630	MAPK1	5594	8	5	27	Show
GSE54993	MAPK1	5594	3	6	61	Show
GSE54994	MAPK1	5594	11	7	35	Show
GSE60625	MAPK1	5594	5	0	6	Show
GSE74703	MAPK1	5594	3	5	28	Show
GSE74704	MAPK1	5594	2	4	14	Show
TCGA	MAPK1	5594	27	16	53	Show

Total number of gains: 105; Total number of losses: 65; Total Number of normals: 318.  Download Data

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Somatic mutations of MAPK1:

 

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Highly correlated genes for MAPK1:

 

Showing top 20/362 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
MAPK1	FAM98B	0.813426	3	0	3
MAPK1	PRPF38A	0.789336	3	0	3
MAPK1	PTPN11	0.780794	3	0	3
MAPK1	DOCK7	0.764389	3	0	3
MAPK1	ZNF664	0.75847	3	0	3
MAPK1	BNIP2	0.745716	3	0	3
MAPK1	TCHP	0.740173	3	0	3
MAPK1	ZXDB	0.725636	3	0	3
MAPK1	ATF1	0.725475	3	0	3
MAPK1	PLEKHM3	0.723206	3	0	3
MAPK1	AQR	0.7183	3	0	3
MAPK1	PCMTD2	0.71827	3	0	3
MAPK1	DDA1	0.71417	3	0	3
MAPK1	TMBIM4	0.708673	4	0	3
MAPK1	INTS10	0.700922	3	0	3
MAPK1	HERPUD1	0.700234	3	0	3
MAPK1	C5orf51	0.699261	3	0	3
MAPK1	NDUFV2	0.699135	3	0	3
MAPK1	BTBD1	0.697905	3	0	3
MAPK1	DDX23	0.696573	3	0	3

For details and further investigation, click here