FASLG

 

Full name: Fas ligand Alias Symbol: FasL|CD178
Type: protein-coding gene Cytoband: 1q24.3
Entrez ID: 356 HGNC ID: HGNC:11936 Ensembl Gene: ENSG00000117560 OMIM ID: 134638
Drug and gene relationship at DGIdb

 

FASLG involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04068FoxO signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04650Natural killer cell mediated cytotoxicity
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05162Measles
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer

 

Expression of FASLG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FASLG 356 210865_at -0.0323 0.9135
GSE20347 FASLG 356 210865_at -0.0775 0.2580
GSE23400 FASLG 356 210865_at -0.1285 0.0038
GSE26886 FASLG 356 210865_at -0.0992 0.5690
GSE29001 FASLG 356 211333_s_at -0.0384 0.8360
GSE38129 FASLG 356 210865_at -0.1727 0.1456
GSE45670 FASLG 356 210865_at 0.0250 0.9179
GSE53622 FASLG 356 25807 -0.0240 0.8703
GSE53624 FASLG 356 25807 -0.1171 0.3702
GSE63941 FASLG 356 210865_at 0.3316 0.0391
GSE77861 FASLG 356 210865_at -0.1825 0.1463
GSE97050 FASLG 356 A_23_P369815 0.0880 0.6847
SRP133303 FASLG 356 RNAseq -0.2399 0.5843
TCGA FASLG 356 RNAseq 0.5199 0.2772

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by FASLG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FASLG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FASLG 356 13 0 17
GSE20123 FASLG 356 13 0 17
GSE43470 FASLG 356 7 2 34
GSE46452 FASLG 356 3 1 55
GSE47630 FASLG 356 14 0 26
GSE54993 FASLG 356 0 6 64
GSE54994 FASLG 356 16 0 37
GSE60625 FASLG 356 0 0 11
GSE74703 FASLG 356 7 2 27
GSE74704 FASLG 356 6 0 14
TCGA FASLG 356 41 3 52

Total number of gains: 120; Total number of losses: 14; Total Number of normals: 354.  

 

Somatic mutations of FASLG:

 

Generating mutation plots.

 

Highly correlated genes for FASLG:

 

Showing top 20/567 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FASLGMAGEA80.779163303
FASLGGUCY2C0.733024303
FASLGACSBG20.720891403
FASLGSPTA10.719669403
FASLGCRABP10.718303
FASLGBRSK10.717949303
FASLGCLCA10.710382404
FASLGDAGLA0.709069505
FASLGINHBC0.708851303
FASLGHOXA11-AS0.705431303
FASLGRNF50.70533404
FASLGKLK20.703125504
FASLGMPP30.701388303
FASLGKCNAB30.699214605
FASLGCELF30.693997808
FASLGAOC20.692894504
FASLGCDH230.692745303
FASLGIL1RAPL20.692386504
FASLGPGC0.689254403
FASLGTNXB0.687397404

For details and further investigation, click here