| Full name: GRB2 related adaptor protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 10750 | HGNC ID: HGNC:4562 | Ensembl Gene: ENSG00000154016 | OMIM ID: 604330 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GRAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRAP | 10750 | 229726_at | 0.0455 | 0.9047 | |
| GSE20347 | GRAP | 10750 | 206620_at | -0.0501 | 0.5081 | |
| GSE23400 | GRAP | 10750 | 206620_at | -0.1000 | 0.0003 | |
| GSE26886 | GRAP | 10750 | 229726_at | 0.3811 | 0.0209 | |
| GSE29001 | GRAP | 10750 | 206620_at | -0.1112 | 0.3115 | |
| GSE38129 | GRAP | 10750 | 206620_at | -0.0669 | 0.3903 | |
| GSE45670 | GRAP | 10750 | 229726_at | 0.0458 | 0.6607 | |
| GSE63941 | GRAP | 10750 | 206620_at | 0.0088 | 0.9665 | |
| GSE77861 | GRAP | 10750 | 229726_at | -0.0448 | 0.7632 | |
| GSE97050 | GRAP | 10750 | A_23_P392962 | 0.4618 | 0.2467 | |
| SRP007169 | GRAP | 10750 | RNAseq | 2.6160 | 0.0271 | |
| SRP064894 | GRAP | 10750 | RNAseq | 1.4243 | 0.0000 | |
| SRP133303 | GRAP | 10750 | RNAseq | -0.1585 | 0.4680 | |
| SRP159526 | GRAP | 10750 | RNAseq | -0.7573 | 0.2251 | |
| SRP193095 | GRAP | 10750 | RNAseq | 0.7318 | 0.0193 | |
| SRP219564 | GRAP | 10750 | RNAseq | 0.8871 | 0.0072 | |
| TCGA | GRAP | 10750 | RNAseq | 0.2308 | 0.1660 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GRAP expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GRAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRAP | 10750 | 4 | 3 | 23 | |
| GSE20123 | GRAP | 10750 | 4 | 4 | 22 | |
| GSE43470 | GRAP | 10750 | 1 | 5 | 37 | |
| GSE46452 | GRAP | 10750 | 34 | 1 | 24 | |
| GSE47630 | GRAP | 10750 | 7 | 1 | 32 | |
| GSE54993 | GRAP | 10750 | 3 | 3 | 64 | |
| GSE54994 | GRAP | 10750 | 6 | 6 | 41 | |
| GSE60625 | GRAP | 10750 | 4 | 0 | 7 | |
| GSE74703 | GRAP | 10750 | 1 | 2 | 33 | |
| GSE74704 | GRAP | 10750 | 3 | 1 | 16 | |
| TCGA | GRAP | 10750 | 19 | 24 | 53 |
Total number of gains: 86; Total number of losses: 50; Total Number of normals: 352.
Somatic mutations of GRAP:
Generating mutation plots.
Highly correlated genes for GRAP:
Showing top 20/358 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRAP | NKAIN4 | 0.830097 | 3 | 0 | 3 |
| GRAP | FFAR1 | 0.775354 | 3 | 0 | 3 |
| GRAP | CLTCL1 | 0.770445 | 3 | 0 | 3 |
| GRAP | ODF3L2 | 0.765922 | 3 | 0 | 3 |
| GRAP | CHST13 | 0.756884 | 3 | 0 | 3 |
| GRAP | RHPN1 | 0.746884 | 3 | 0 | 3 |
| GRAP | C19orf81 | 0.736401 | 3 | 0 | 3 |
| GRAP | DNAJB8 | 0.735177 | 3 | 0 | 3 |
| GRAP | SPRED3 | 0.732213 | 3 | 0 | 3 |
| GRAP | MGAT5B | 0.731207 | 3 | 0 | 3 |
| GRAP | PEX11G | 0.7301 | 4 | 0 | 4 |
| GRAP | TMEM179 | 0.728648 | 3 | 0 | 3 |
| GRAP | ISLR2 | 0.726682 | 3 | 0 | 3 |
| GRAP | TUT1 | 0.723131 | 3 | 0 | 3 |
| GRAP | COL20A1 | 0.720902 | 3 | 0 | 3 |
| GRAP | GJD4 | 0.720392 | 3 | 0 | 3 |
| GRAP | PHGR1 | 0.718009 | 3 | 0 | 3 |
| GRAP | MAPK15 | 0.708923 | 3 | 0 | 3 |
| GRAP | RNF151 | 0.708776 | 3 | 0 | 3 |
| GRAP | PLA2G4F | 0.705087 | 4 | 0 | 4 |
For details and further investigation, click here
