| Full name: eukaryotic translation initiation factor 3 subunit K | Alias Symbol: eIF3k|PRO1474|HSPC029|PTD001|PLAC-24|M9|ARG134 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 27335 | HGNC ID: HGNC:24656 | Ensembl Gene: ENSG00000178982 | OMIM ID: 609596 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF3K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF3K | 27335 | 212716_s_at | -0.3191 | 0.1189 | |
| GSE20347 | EIF3K | 27335 | 212716_s_at | -0.4226 | 0.0203 | |
| GSE23400 | EIF3K | 27335 | 221494_x_at | -0.2330 | 0.0053 | |
| GSE26886 | EIF3K | 27335 | 212716_s_at | 0.3400 | 0.0107 | |
| GSE29001 | EIF3K | 27335 | 221494_x_at | -0.3349 | 0.2304 | |
| GSE38129 | EIF3K | 27335 | 212716_s_at | -0.3255 | 0.0168 | |
| GSE45670 | EIF3K | 27335 | 212716_s_at | -0.2475 | 0.0213 | |
| GSE53622 | EIF3K | 27335 | 68057 | -0.5196 | 0.0000 | |
| GSE53624 | EIF3K | 27335 | 68057 | -0.2033 | 0.0053 | |
| GSE63941 | EIF3K | 27335 | 212716_s_at | 0.5125 | 0.1267 | |
| GSE77861 | EIF3K | 27335 | 221494_x_at | 0.0250 | 0.9558 | |
| GSE97050 | EIF3K | 27335 | A_24_P330971 | -0.1652 | 0.4009 | |
| SRP007169 | EIF3K | 27335 | RNAseq | -0.3468 | 0.4972 | |
| SRP008496 | EIF3K | 27335 | RNAseq | -0.7053 | 0.0319 | |
| SRP064894 | EIF3K | 27335 | RNAseq | 0.1368 | 0.6630 | |
| SRP133303 | EIF3K | 27335 | RNAseq | -0.1481 | 0.5300 | |
| SRP159526 | EIF3K | 27335 | RNAseq | -0.1535 | 0.6565 | |
| SRP193095 | EIF3K | 27335 | RNAseq | -0.7360 | 0.0000 | |
| SRP219564 | EIF3K | 27335 | RNAseq | -0.3390 | 0.2366 | |
| TCGA | EIF3K | 27335 | RNAseq | -0.0392 | 0.4583 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF3K expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF3K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF3K | 27335 | 7 | 4 | 19 | |
| GSE20123 | EIF3K | 27335 | 7 | 3 | 20 | |
| GSE43470 | EIF3K | 27335 | 4 | 10 | 29 | |
| GSE46452 | EIF3K | 27335 | 47 | 2 | 10 | |
| GSE47630 | EIF3K | 27335 | 9 | 5 | 26 | |
| GSE54993 | EIF3K | 27335 | 17 | 3 | 50 | |
| GSE54994 | EIF3K | 27335 | 6 | 9 | 38 | |
| GSE60625 | EIF3K | 27335 | 9 | 0 | 2 | |
| GSE74703 | EIF3K | 27335 | 4 | 6 | 26 | |
| GSE74704 | EIF3K | 27335 | 7 | 1 | 12 | |
| TCGA | EIF3K | 27335 | 16 | 15 | 65 |
Total number of gains: 133; Total number of losses: 58; Total Number of normals: 297.
Somatic mutations of EIF3K:
Generating mutation plots.
Highly correlated genes for EIF3K:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF3K | NUPR1 | 0.766965 | 3 | 0 | 3 |
| EIF3K | POLR2I | 0.708903 | 12 | 0 | 12 |
| EIF3K | HNRNPA0 | 0.699441 | 3 | 0 | 3 |
| EIF3K | COX6B1 | 0.688521 | 12 | 0 | 10 |
| EIF3K | DHRS4L2 | 0.682061 | 3 | 0 | 3 |
| EIF3K | ESD | 0.677741 | 3 | 0 | 3 |
| EIF3K | ECH1 | 0.66442 | 10 | 0 | 9 |
| EIF3K | TPPP | 0.661954 | 4 | 0 | 3 |
| EIF3K | ZSCAN12 | 0.661132 | 3 | 0 | 3 |
| EIF3K | ANGPTL6 | 0.658944 | 3 | 0 | 3 |
| EIF3K | GPR108 | 0.658479 | 3 | 0 | 3 |
| EIF3K | PYROXD1 | 0.658071 | 4 | 0 | 4 |
| EIF3K | TMEM19 | 0.657385 | 3 | 0 | 3 |
| EIF3K | ZFAND5 | 0.656862 | 3 | 0 | 3 |
| EIF3K | CLYBL | 0.655586 | 5 | 0 | 3 |
| EIF3K | PIAS1 | 0.655263 | 5 | 0 | 5 |
| EIF3K | UQCR11 | 0.654181 | 8 | 0 | 7 |
| EIF3K | DIS3L | 0.653698 | 3 | 0 | 3 |
| EIF3K | RNASEK | 0.649693 | 3 | 0 | 3 |
| EIF3K | SNX7 | 0.646885 | 3 | 0 | 3 |
For details and further investigation, click here
