| Full name: mucin 5B, oligomeric mucus/gel-forming | Alias Symbol: MG1 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 727897 | HGNC ID: HGNC:7516 | Ensembl Gene: ENSG00000117983 | OMIM ID: 600770 |
| Drug and gene relationship at DGIdb | |||
Expression of MUC5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MUC5B | 727897 | 213432_at | -2.9795 | 0.1928 | |
| GSE20347 | MUC5B | 727897 | 222268_x_at | -0.1800 | 0.1336 | |
| GSE23400 | MUC5B | 727897 | 213432_at | -2.3286 | 0.0000 | |
| GSE26886 | MUC5B | 727897 | 213432_at | 0.0523 | 0.6667 | |
| GSE29001 | MUC5B | 727897 | 213432_at | -0.4458 | 0.0144 | |
| GSE38129 | MUC5B | 727897 | 213432_at | -0.9174 | 0.0003 | |
| GSE45670 | MUC5B | 727897 | 213432_at | -1.6217 | 0.0051 | |
| GSE53622 | MUC5B | 727897 | 70264 | -2.9426 | 0.0000 | |
| GSE53624 | MUC5B | 727897 | 70264 | -3.0204 | 0.0000 | |
| GSE63941 | MUC5B | 727897 | 213432_at | 0.4045 | 0.4740 | |
| GSE77861 | MUC5B | 727897 | 222268_x_at | -0.3948 | 0.0139 | |
| GSE97050 | MUC5B | 727897 | A_24_P102650 | -0.9272 | 0.1623 | |
| SRP064894 | MUC5B | 727897 | RNAseq | -8.0847 | 0.0000 | |
| SRP133303 | MUC5B | 727897 | RNAseq | -8.3253 | 0.0000 | |
| SRP159526 | MUC5B | 727897 | RNAseq | -0.7248 | 0.7270 | |
| SRP193095 | MUC5B | 727897 | RNAseq | 0.4920 | 0.4304 | |
| TCGA | MUC5B | 727897 | RNAseq | -1.6755 | 0.0053 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by MUC5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MUC5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MUC5B | 727897 | 1 | 11 | 18 | |
| GSE20123 | MUC5B | 727897 | 1 | 12 | 17 | |
| GSE43470 | MUC5B | 727897 | 1 | 10 | 32 | |
| GSE46452 | MUC5B | 727897 | 7 | 8 | 44 | |
| GSE47630 | MUC5B | 727897 | 4 | 12 | 24 | |
| GSE54993 | MUC5B | 727897 | 3 | 1 | 66 | |
| GSE54994 | MUC5B | 727897 | 1 | 12 | 40 | |
| GSE60625 | MUC5B | 727897 | 0 | 0 | 11 | |
| GSE74703 | MUC5B | 727897 | 1 | 8 | 27 | |
| GSE74704 | MUC5B | 727897 | 0 | 8 | 12 | |
| TCGA | MUC5B | 727897 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of MUC5B:
Generating mutation plots.
Highly correlated genes for MUC5B:
Showing top 20/234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MUC5B | BPIFB1 | 0.908993 | 5 | 0 | 5 |
| MUC5B | BPIFB2 | 0.905951 | 6 | 0 | 6 |
| MUC5B | C6orf58 | 0.822525 | 6 | 0 | 5 |
| MUC5B | LRRC26 | 0.781178 | 3 | 0 | 3 |
| MUC5B | AZGP1 | 0.755632 | 9 | 0 | 8 |
| MUC5B | ZG16B | 0.745206 | 7 | 0 | 5 |
| MUC5B | SCGB2A2 | 0.732064 | 9 | 0 | 7 |
| MUC5B | GP2 | 0.72299 | 7 | 0 | 7 |
| MUC5B | RAB36 | 0.708187 | 3 | 0 | 3 |
| MUC5B | MCF2 | 0.702464 | 3 | 0 | 3 |
| MUC5B | TSPAN8 | 0.696267 | 8 | 0 | 7 |
| MUC5B | TFF3 | 0.69208 | 11 | 0 | 8 |
| MUC5B | SCGB2A1 | 0.687706 | 5 | 0 | 3 |
| MUC5B | PROM1 | 0.683876 | 6 | 0 | 6 |
| MUC5B | SCGB1D2 | 0.663828 | 9 | 0 | 7 |
| MUC5B | PIGR | 0.659072 | 9 | 0 | 7 |
| MUC5B | CHRM1 | 0.655048 | 6 | 0 | 5 |
| MUC5B | SFTA2 | 0.654288 | 4 | 0 | 3 |
| MUC5B | GLYATL2 | 0.644688 | 4 | 0 | 4 |
| MUC5B | CAPN8 | 0.643964 | 5 | 0 | 4 |
For details and further investigation, click here
