| Full name: phosphodiesterase 3B | Alias Symbol: HcGIP1 | ||
| Type: protein-coding gene | Cytoband: 11p15.2 | ||
| Entrez ID: 5140 | HGNC ID: HGNC:8779 | Ensembl Gene: ENSG00000152270 | OMIM ID: 602047 |
| Drug and gene relationship at DGIdb | |||
PDE3B involved pathways:
Expression of PDE3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE3B | 5140 | 214582_at | 0.1831 | 0.7551 | |
| GSE20347 | PDE3B | 5140 | 208591_s_at | 0.0836 | 0.5006 | |
| GSE23400 | PDE3B | 5140 | 208591_s_at | -0.0446 | 0.3074 | |
| GSE29001 | PDE3B | 5140 | 208591_s_at | -0.2601 | 0.2599 | |
| GSE38129 | PDE3B | 5140 | 208591_s_at | -0.0706 | 0.4641 | |
| GSE53622 | PDE3B | 5140 | 120041 | -0.0400 | 0.8251 | |
| GSE53624 | PDE3B | 5140 | 120041 | 0.3258 | 0.0336 | |
| GSE97050 | PDE3B | 5140 | A_33_P3240018 | 0.1693 | 0.7465 | |
| SRP007169 | PDE3B | 5140 | RNAseq | 3.3666 | 0.0000 | |
| SRP008496 | PDE3B | 5140 | RNAseq | 2.3999 | 0.0002 | |
| SRP064894 | PDE3B | 5140 | RNAseq | 0.1032 | 0.7961 | |
| SRP133303 | PDE3B | 5140 | RNAseq | 0.5481 | 0.0898 | |
| SRP159526 | PDE3B | 5140 | RNAseq | 0.3157 | 0.5720 | |
| SRP193095 | PDE3B | 5140 | RNAseq | 1.2681 | 0.0000 | |
| TCGA | PDE3B | 5140 | RNAseq | -0.2039 | 0.2166 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PDE3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE3B | 5140 | 1 | 10 | 19 | |
| GSE20123 | PDE3B | 5140 | 1 | 10 | 19 | |
| GSE43470 | PDE3B | 5140 | 1 | 5 | 37 | |
| GSE46452 | PDE3B | 5140 | 7 | 5 | 47 | |
| GSE47630 | PDE3B | 5140 | 3 | 11 | 26 | |
| GSE54993 | PDE3B | 5140 | 3 | 1 | 66 | |
| GSE54994 | PDE3B | 5140 | 4 | 12 | 37 | |
| GSE60625 | PDE3B | 5140 | 0 | 0 | 11 | |
| GSE74703 | PDE3B | 5140 | 1 | 3 | 32 | |
| GSE74704 | PDE3B | 5140 | 0 | 9 | 11 | |
| TCGA | PDE3B | 5140 | 11 | 31 | 54 |
Total number of gains: 32; Total number of losses: 97; Total Number of normals: 359.
Somatic mutations of PDE3B:
Generating mutation plots.
Highly correlated genes for PDE3B:
Showing top 20/505 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE3B | PRTN3 | 0.777657 | 3 | 0 | 3 |
| PDE3B | CHML | 0.765336 | 3 | 0 | 3 |
| PDE3B | VAMP2 | 0.749236 | 3 | 0 | 3 |
| PDE3B | MLNR | 0.743105 | 3 | 0 | 3 |
| PDE3B | STRADA | 0.734934 | 3 | 0 | 3 |
| PDE3B | RAB23 | 0.719632 | 3 | 0 | 3 |
| PDE3B | CBL | 0.715779 | 5 | 0 | 5 |
| PDE3B | IL1RAPL2 | 0.713903 | 4 | 0 | 4 |
| PDE3B | GAS6 | 0.708604 | 3 | 0 | 3 |
| PDE3B | SF3A2 | 0.708106 | 3 | 0 | 3 |
| PDE3B | GRAMD1B | 0.706378 | 3 | 0 | 3 |
| PDE3B | NXPE4 | 0.704743 | 4 | 0 | 4 |
| PDE3B | MAS1 | 0.704335 | 4 | 0 | 4 |
| PDE3B | PDCD1 | 0.699649 | 4 | 0 | 4 |
| PDE3B | EDA2R | 0.692911 | 5 | 0 | 4 |
| PDE3B | ATG10 | 0.690719 | 5 | 0 | 4 |
| PDE3B | TAS2R7 | 0.690383 | 3 | 0 | 3 |
| PDE3B | CCDC7 | 0.68883 | 5 | 0 | 5 |
| PDE3B | ASH1L | 0.688251 | 4 | 0 | 3 |
| PDE3B | TCL1B | 0.687686 | 5 | 0 | 5 |
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