| Full name: sterol O-acyltransferase 2 | Alias Symbol: ACAT2 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 8435 | HGNC ID: HGNC:11178 | Ensembl Gene: ENSG00000167780 | OMIM ID: 601311 |
| Drug and gene relationship at DGIdb | |||
Expression of SOAT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOAT2 | 8435 | 210677_at | -0.0309 | 0.9027 | |
| GSE20347 | SOAT2 | 8435 | 210677_at | 0.0666 | 0.3844 | |
| GSE23400 | SOAT2 | 8435 | 210677_at | -0.0605 | 0.1527 | |
| GSE26886 | SOAT2 | 8435 | 210677_at | -0.1419 | 0.2321 | |
| GSE29001 | SOAT2 | 8435 | 210677_at | 0.0571 | 0.7519 | |
| GSE38129 | SOAT2 | 8435 | 210677_at | -0.0414 | 0.5443 | |
| GSE45670 | SOAT2 | 8435 | 210677_at | 0.1363 | 0.2247 | |
| GSE53622 | SOAT2 | 8435 | 70366 | 0.4943 | 0.0004 | |
| GSE53624 | SOAT2 | 8435 | 70366 | 0.5700 | 0.0000 | |
| GSE63941 | SOAT2 | 8435 | 210677_at | 0.1337 | 0.5015 | |
| GSE77861 | SOAT2 | 8435 | 210677_at | -0.1079 | 0.1898 | |
| TCGA | SOAT2 | 8435 | RNAseq | -0.2652 | 0.7864 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SOAT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOAT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOAT2 | 8435 | 8 | 1 | 21 | |
| GSE20123 | SOAT2 | 8435 | 8 | 1 | 21 | |
| GSE43470 | SOAT2 | 8435 | 3 | 0 | 40 | |
| GSE46452 | SOAT2 | 8435 | 7 | 1 | 51 | |
| GSE47630 | SOAT2 | 8435 | 10 | 2 | 28 | |
| GSE54993 | SOAT2 | 8435 | 0 | 5 | 65 | |
| GSE54994 | SOAT2 | 8435 | 4 | 1 | 48 | |
| GSE60625 | SOAT2 | 8435 | 0 | 0 | 11 | |
| GSE74703 | SOAT2 | 8435 | 3 | 0 | 33 | |
| GSE74704 | SOAT2 | 8435 | 5 | 1 | 14 | |
| TCGA | SOAT2 | 8435 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of SOAT2:
Generating mutation plots.
Highly correlated genes for SOAT2:
Showing top 20/564 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOAT2 | DAB1 | 0.719121 | 3 | 0 | 3 |
| SOAT2 | UBQLN3 | 0.685951 | 4 | 0 | 3 |
| SOAT2 | PDZD3 | 0.679004 | 5 | 0 | 5 |
| SOAT2 | ATXN8OS | 0.677522 | 5 | 0 | 5 |
| SOAT2 | PZP | 0.674233 | 3 | 0 | 3 |
| SOAT2 | PRAMEF10 | 0.673864 | 4 | 0 | 4 |
| SOAT2 | KIR2DL2 | 0.667265 | 4 | 0 | 4 |
| SOAT2 | KRTAP9-9 | 0.665001 | 3 | 0 | 3 |
| SOAT2 | RHAG | 0.663991 | 3 | 0 | 3 |
| SOAT2 | CCDC87 | 0.663626 | 4 | 0 | 4 |
| SOAT2 | POU4F2 | 0.663205 | 3 | 0 | 3 |
| SOAT2 | PDE3B | 0.660975 | 4 | 0 | 4 |
| SOAT2 | HRG | 0.660045 | 4 | 0 | 4 |
| SOAT2 | CLDN11 | 0.656742 | 6 | 0 | 6 |
| SOAT2 | CHRM2 | 0.656678 | 4 | 0 | 4 |
| SOAT2 | CYP2D6 | 0.655446 | 4 | 0 | 4 |
| SOAT2 | EPHB1 | 0.655423 | 3 | 0 | 3 |
| SOAT2 | CDH10 | 0.654607 | 6 | 0 | 6 |
| SOAT2 | CACNG5 | 0.654572 | 4 | 0 | 3 |
| SOAT2 | SPACA1 | 0.652441 | 5 | 0 | 4 |
For details and further investigation, click here
