CALML3

 

Full name: calmodulin like 3 Alias Symbol: CLP
Type: protein-coding gene Cytoband: 10p15.1
Entrez ID: 810 HGNC ID: HGNC:1452 Ensembl Gene: ENSG00000178363 OMIM ID: 114184
Drug and gene relationship at DGIdb

 

CALML3 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa05010Alzheimer's disease
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05152Tuberculosis
hsa05214Glioma

 

Expression of CALML3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CALML3 810 210020_x_at -0.5556 0.4193
GSE20347 CALML3 810 210020_x_at -1.0688 0.0056
GSE23400 CALML3 810 210020_x_at -0.7077 0.0001
GSE26886 CALML3 810 210020_x_at -1.4548 0.0001
GSE29001 CALML3 810 210020_x_at -1.0237 0.0069
GSE38129 CALML3 810 210020_x_at 0.2341 0.7445
GSE45670 CALML3 810 210020_x_at 0.0521 0.8616
GSE63941 CALML3 810 210020_x_at 1.8942 0.3274
GSE77861 CALML3 810 210020_x_at -0.3286 0.3610
GSE97050 CALML3 810 A_23_P393080 -0.1564 0.5108
SRP007169 CALML3 810 RNAseq -3.1973 0.0000
SRP008496 CALML3 810 RNAseq -2.1183 0.0000
SRP064894 CALML3 810 RNAseq -0.3833 0.4433
SRP133303 CALML3 810 RNAseq -1.3025 0.0009
SRP159526 CALML3 810 RNAseq -1.2604 0.1235
SRP219564 CALML3 810 RNAseq -1.7686 0.1221
TCGA CALML3 810 RNAseq 1.4080 0.0000

Upregulated datasets: 1; Downregulated datasets: 6.  

 

Survival by CALML3 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of CALML3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CALML3 810 6 7 17
GSE20123 CALML3 810 6 6 18
GSE43470 CALML3 810 4 6 33
GSE46452 CALML3 810 2 14 43
GSE47630 CALML3 810 6 14 20
GSE54993 CALML3 810 11 0 59
GSE54994 CALML3 810 5 10 38
GSE60625 CALML3 810 0 0 11
GSE74703 CALML3 810 3 4 29
GSE74704 CALML3 810 1 5 14
TCGA CALML3 810 21 24 51

Total number of gains: 65; Total number of losses: 90; Total Number of normals: 333.  

 

Somatic mutations of CALML3:

 

Generating mutation plots.

 

Highly correlated genes for CALML3:

 

Showing top 20/566 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CALML3PHLDB30.717049505
CALML3IVL0.714979808
CALML3SBSN0.712162504
CALML3LYPD30.7037531009
CALML3CRABP20.698609909
CALML3SLC35A40.697331503
CALML3SULT2B10.688959909
CALML3DEGS20.675128504
CALML3RAB11FIP40.670939303
CALML3PITX10.670395908
CALML3TMEM790.667038605
CALML3EVPL0.665111908
CALML3DGKA0.662491806
CALML3RAPGEFL10.658741705
CALML3VSIG10L0.65429604
CALML3MAPK130.654036908
CALML3GIPC10.6532221008
CALML3TECR0.652963909
CALML3KLK100.652884706
CALML3IL20RB0.651763505

For details and further investigation, click here