| Full name: GIPC PDZ domain containing family member 1 | Alias Symbol: TIP-2|Hs.6454|GIPC|SEMCAP|GLUT1CBP|SYNECTIN|NIP | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 10755 | HGNC ID: HGNC:1226 | Ensembl Gene: ENSG00000123159 | OMIM ID: 605072 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GIPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GIPC1 | 10755 | 207525_s_at | -0.1624 | 0.7944 | |
| GSE20347 | GIPC1 | 10755 | 207525_s_at | -0.8553 | 0.0000 | |
| GSE23400 | GIPC1 | 10755 | 207525_s_at | -0.6292 | 0.0000 | |
| GSE26886 | GIPC1 | 10755 | 207525_s_at | -0.7795 | 0.0009 | |
| GSE29001 | GIPC1 | 10755 | 207525_s_at | -0.7785 | 0.0054 | |
| GSE38129 | GIPC1 | 10755 | 207525_s_at | -0.5343 | 0.0198 | |
| GSE45670 | GIPC1 | 10755 | 207525_s_at | -0.0406 | 0.8211 | |
| GSE53622 | GIPC1 | 10755 | 30967 | -1.1433 | 0.0000 | |
| GSE53624 | GIPC1 | 10755 | 30967 | -1.1199 | 0.0000 | |
| GSE63941 | GIPC1 | 10755 | 207525_s_at | 0.5084 | 0.1256 | |
| GSE77861 | GIPC1 | 10755 | 207525_s_at | -0.2862 | 0.2253 | |
| GSE97050 | GIPC1 | 10755 | A_33_P3390102 | -0.3740 | 0.3448 | |
| SRP007169 | GIPC1 | 10755 | RNAseq | -3.0660 | 0.0000 | |
| SRP008496 | GIPC1 | 10755 | RNAseq | -2.9373 | 0.0000 | |
| SRP064894 | GIPC1 | 10755 | RNAseq | -1.1297 | 0.0010 | |
| SRP133303 | GIPC1 | 10755 | RNAseq | -1.1548 | 0.0000 | |
| SRP159526 | GIPC1 | 10755 | RNAseq | -1.6885 | 0.0000 | |
| SRP193095 | GIPC1 | 10755 | RNAseq | -1.2144 | 0.0000 | |
| SRP219564 | GIPC1 | 10755 | RNAseq | -0.9970 | 0.0907 | |
| TCGA | GIPC1 | 10755 | RNAseq | 0.0835 | 0.2242 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by GIPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GIPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GIPC1 | 10755 | 4 | 2 | 24 | |
| GSE20123 | GIPC1 | 10755 | 3 | 1 | 26 | |
| GSE43470 | GIPC1 | 10755 | 2 | 6 | 35 | |
| GSE46452 | GIPC1 | 10755 | 47 | 1 | 11 | |
| GSE47630 | GIPC1 | 10755 | 4 | 7 | 29 | |
| GSE54993 | GIPC1 | 10755 | 15 | 4 | 51 | |
| GSE54994 | GIPC1 | 10755 | 6 | 13 | 34 | |
| GSE60625 | GIPC1 | 10755 | 9 | 0 | 2 | |
| GSE74703 | GIPC1 | 10755 | 2 | 4 | 30 | |
| GSE74704 | GIPC1 | 10755 | 0 | 1 | 19 | |
| TCGA | GIPC1 | 10755 | 18 | 11 | 67 |
Total number of gains: 110; Total number of losses: 50; Total Number of normals: 328.
Somatic mutations of GIPC1:
Generating mutation plots.
Highly correlated genes for GIPC1:
Showing top 20/1494 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GIPC1 | UPK3B | 0.830647 | 3 | 0 | 3 |
| GIPC1 | EPGN | 0.784435 | 3 | 0 | 3 |
| GIPC1 | KAZN | 0.77652 | 10 | 0 | 10 |
| GIPC1 | SH3GL1 | 0.771887 | 11 | 0 | 10 |
| GIPC1 | EVPL | 0.765283 | 13 | 0 | 11 |
| GIPC1 | TOM1 | 0.764448 | 11 | 0 | 10 |
| GIPC1 | KPRP | 0.760535 | 3 | 0 | 3 |
| GIPC1 | NCCRP1 | 0.755483 | 4 | 0 | 3 |
| GIPC1 | PKP3 | 0.755301 | 12 | 0 | 11 |
| GIPC1 | S100A16 | 0.754685 | 8 | 0 | 8 |
| GIPC1 | SFI1 | 0.754607 | 3 | 0 | 3 |
| GIPC1 | NBEAL2 | 0.753668 | 13 | 0 | 12 |
| GIPC1 | ALS2CL | 0.753559 | 11 | 0 | 11 |
| GIPC1 | CPTP | 0.75349 | 8 | 0 | 8 |
| GIPC1 | DUOX1 | 0.753317 | 12 | 0 | 12 |
| GIPC1 | MALL | 0.750007 | 12 | 0 | 11 |
| GIPC1 | TECR | 0.749226 | 13 | 0 | 12 |
| GIPC1 | MAPK3 | 0.749063 | 11 | 0 | 11 |
| GIPC1 | RARG | 0.748698 | 12 | 0 | 11 |
| GIPC1 | ARHGAP40 | 0.746566 | 3 | 0 | 3 |
For details and further investigation, click here
