| Full name: interleukin 20 receptor subunit beta | Alias Symbol: DIRS1|IL-20R2|MGC34923 | ||
| Type: protein-coding gene | Cytoband: 3q22.3 | ||
| Entrez ID: 53833 | HGNC ID: HGNC:6004 | Ensembl Gene: ENSG00000174564 | OMIM ID: 605621 |
| Drug and gene relationship at DGIdb | |||
IL20RB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL20RB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL20RB | 53833 | 228575_at | -1.2704 | 0.5230 | |
| GSE26886 | IL20RB | 53833 | 228575_at | -3.5402 | 0.0000 | |
| GSE45670 | IL20RB | 53833 | 228575_at | -0.1601 | 0.7237 | |
| GSE53622 | IL20RB | 53833 | 94514 | -1.3565 | 0.0001 | |
| GSE53624 | IL20RB | 53833 | 94514 | -1.5133 | 0.0000 | |
| GSE63941 | IL20RB | 53833 | 228575_at | 0.1134 | 0.9522 | |
| GSE77861 | IL20RB | 53833 | 228575_at | -1.5917 | 0.0797 | |
| GSE97050 | IL20RB | 53833 | A_23_P91850 | 0.0168 | 0.9832 | |
| SRP007169 | IL20RB | 53833 | RNAseq | -2.6764 | 0.0001 | |
| SRP008496 | IL20RB | 53833 | RNAseq | -2.5464 | 0.0024 | |
| SRP064894 | IL20RB | 53833 | RNAseq | -0.9475 | 0.0447 | |
| SRP133303 | IL20RB | 53833 | RNAseq | -0.3668 | 0.5200 | |
| SRP159526 | IL20RB | 53833 | RNAseq | -1.9865 | 0.0021 | |
| SRP219564 | IL20RB | 53833 | RNAseq | -1.2731 | 0.2488 | |
| TCGA | IL20RB | 53833 | RNAseq | 1.1818 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by IL20RB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL20RB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL20RB | 53833 | 16 | 0 | 14 | |
| GSE20123 | IL20RB | 53833 | 16 | 0 | 14 | |
| GSE43470 | IL20RB | 53833 | 22 | 0 | 21 | |
| GSE46452 | IL20RB | 53833 | 15 | 4 | 40 | |
| GSE47630 | IL20RB | 53833 | 18 | 3 | 19 | |
| GSE54993 | IL20RB | 53833 | 2 | 8 | 60 | |
| GSE54994 | IL20RB | 53833 | 32 | 1 | 20 | |
| GSE60625 | IL20RB | 53833 | 0 | 6 | 5 | |
| GSE74703 | IL20RB | 53833 | 19 | 0 | 17 | |
| GSE74704 | IL20RB | 53833 | 11 | 0 | 9 | |
| TCGA | IL20RB | 53833 | 60 | 6 | 30 |
Total number of gains: 211; Total number of losses: 28; Total Number of normals: 249.
Somatic mutations of IL20RB:
Generating mutation plots.
Highly correlated genes for IL20RB:
Showing top 20/892 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL20RB | SERPINB3 | 0.845327 | 4 | 0 | 4 |
| IL20RB | LCN2 | 0.776482 | 5 | 0 | 5 |
| IL20RB | TGM1 | 0.764816 | 8 | 0 | 7 |
| IL20RB | TMEM79 | 0.763981 | 8 | 0 | 8 |
| IL20RB | S100A9 | 0.756718 | 8 | 0 | 7 |
| IL20RB | GRHL3 | 0.752333 | 6 | 0 | 6 |
| IL20RB | TMEM40 | 0.748197 | 7 | 0 | 7 |
| IL20RB | METRNL | 0.74646 | 6 | 0 | 6 |
| IL20RB | PRSS8 | 0.743527 | 4 | 0 | 4 |
| IL20RB | FAM160A1 | 0.742816 | 6 | 0 | 6 |
| IL20RB | RABGGTA | 0.739939 | 6 | 0 | 6 |
| IL20RB | KLK11 | 0.738621 | 7 | 0 | 7 |
| IL20RB | CLTB | 0.736427 | 7 | 0 | 7 |
| IL20RB | LYPD3 | 0.735009 | 8 | 0 | 7 |
| IL20RB | IL36RN | 0.733289 | 4 | 0 | 4 |
| IL20RB | GJB2 | 0.728833 | 6 | 0 | 6 |
| IL20RB | ARAP2 | 0.727937 | 3 | 0 | 3 |
| IL20RB | SBSN | 0.721207 | 8 | 0 | 7 |
| IL20RB | ITPKC | 0.720484 | 5 | 0 | 5 |
| IL20RB | SLPI | 0.718916 | 7 | 0 | 6 |
For details and further investigation, click here
