| Full name: kallikrein related peptidase 10 | Alias Symbol: NES1 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 5655 | HGNC ID: HGNC:6358 | Ensembl Gene: ENSG00000129451 | OMIM ID: 602673 |
| Drug and gene relationship at DGIdb | |||
Expression of KLK10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK10 | 5655 | 209792_s_at | -1.4812 | 0.5711 | |
| GSE20347 | KLK10 | 5655 | 209792_s_at | -1.9811 | 0.0002 | |
| GSE23400 | KLK10 | 5655 | 209792_s_at | -1.0399 | 0.0000 | |
| GSE26886 | KLK10 | 5655 | 209792_s_at | -3.2242 | 0.0000 | |
| GSE29001 | KLK10 | 5655 | 209792_s_at | -1.8899 | 0.0155 | |
| GSE38129 | KLK10 | 5655 | 209792_s_at | -0.8005 | 0.2346 | |
| GSE45670 | KLK10 | 5655 | 209792_s_at | 0.3046 | 0.3868 | |
| GSE63941 | KLK10 | 5655 | 209792_s_at | 3.1843 | 0.1275 | |
| GSE77861 | KLK10 | 5655 | 209792_s_at | -0.0896 | 0.8384 | |
| SRP007169 | KLK10 | 5655 | RNAseq | -3.8540 | 0.0000 | |
| SRP008496 | KLK10 | 5655 | RNAseq | -3.4930 | 0.0000 | |
| SRP064894 | KLK10 | 5655 | RNAseq | -1.9235 | 0.0002 | |
| SRP133303 | KLK10 | 5655 | RNAseq | -1.1823 | 0.0000 | |
| SRP159526 | KLK10 | 5655 | RNAseq | -2.2288 | 0.0003 | |
| SRP219564 | KLK10 | 5655 | RNAseq | -2.4450 | 0.0184 | |
| TCGA | KLK10 | 5655 | RNAseq | 0.8182 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by KLK10 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KLK10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK10 | 5655 | 3 | 4 | 23 | |
| GSE20123 | KLK10 | 5655 | 3 | 3 | 24 | |
| GSE43470 | KLK10 | 5655 | 4 | 11 | 28 | |
| GSE46452 | KLK10 | 5655 | 45 | 1 | 13 | |
| GSE47630 | KLK10 | 5655 | 9 | 6 | 25 | |
| GSE54993 | KLK10 | 5655 | 17 | 4 | 49 | |
| GSE54994 | KLK10 | 5655 | 4 | 14 | 35 | |
| GSE60625 | KLK10 | 5655 | 9 | 0 | 2 | |
| GSE74703 | KLK10 | 5655 | 4 | 7 | 25 | |
| GSE74704 | KLK10 | 5655 | 3 | 1 | 16 | |
| TCGA | KLK10 | 5655 | 15 | 19 | 62 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of KLK10:
Generating mutation plots.
Highly correlated genes for KLK10:
Showing top 20/593 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK10 | KLK8 | 0.805028 | 9 | 0 | 9 |
| KLK10 | KLK11 | 0.761727 | 10 | 0 | 9 |
| KLK10 | C10orf99 | 0.735344 | 5 | 0 | 5 |
| KLK10 | TMPRSS11E | 0.728628 | 7 | 0 | 7 |
| KLK10 | SULT2B1 | 0.728615 | 9 | 0 | 8 |
| KLK10 | IL36RN | 0.721206 | 8 | 0 | 8 |
| KLK10 | LYPD3 | 0.713112 | 8 | 0 | 7 |
| KLK10 | CERS3 | 0.708312 | 3 | 0 | 3 |
| KLK10 | FUT2 | 0.707895 | 8 | 0 | 7 |
| KLK10 | GSN | 0.706257 | 3 | 0 | 3 |
| KLK10 | KRT80 | 0.705835 | 4 | 0 | 4 |
| KLK10 | EPS8L1 | 0.703873 | 6 | 0 | 6 |
| KLK10 | EVPL | 0.701093 | 6 | 0 | 5 |
| KLK10 | PI3 | 0.700029 | 10 | 0 | 8 |
| KLK10 | TSPAN6 | 0.697886 | 4 | 0 | 4 |
| KLK10 | SERPINB13 | 0.694462 | 8 | 0 | 7 |
| KLK10 | KLK7 | 0.693447 | 10 | 0 | 9 |
| KLK10 | TMPRSS11D | 0.691827 | 8 | 0 | 8 |
| KLK10 | SCEL | 0.68865 | 8 | 0 | 7 |
| KLK10 | LYNX1 | 0.687763 | 5 | 0 | 5 |
For details and further investigation, click here
