CAMK2A

 

Full name: calcium/calmodulin dependent protein kinase II alpha Alias Symbol: KIAA0968|CaMKIINalpha
Type: protein-coding gene Cytoband: 5q32
Entrez ID: 815 HGNC ID: HGNC:1460 Ensembl Gene: ENSG00000070808 OMIM ID: 114078
Drug and gene relationship at DGIdb

 

CAMK2A involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04066HIF-1 signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04971Gastric acid secretion
hsa05031Amphetamine addiction
hsa05152Tuberculosis
hsa05205Proteoglycans in cancer
hsa05214Glioma

 

Expression of CAMK2A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CAMK2A 815 213108_at -0.1867 0.3289
GSE20347 CAMK2A 815 213108_at -0.0500 0.6554
GSE23400 CAMK2A 815 213108_at -0.1786 0.0000
GSE26886 CAMK2A 815 213108_at -0.1501 0.1918
GSE29001 CAMK2A 815 213108_at -0.2509 0.2442
GSE38129 CAMK2A 815 213108_at -0.2942 0.0057
GSE45670 CAMK2A 815 213108_at 0.0169 0.8911
GSE53622 CAMK2A 815 116696 -0.4378 0.0416
GSE53624 CAMK2A 815 76532 -0.1601 0.2359
GSE63941 CAMK2A 815 213108_at 0.1829 0.2492
GSE77861 CAMK2A 815 213108_at -0.1414 0.4019
GSE97050 CAMK2A 815 A_33_P3274647 -1.4997 0.1242
SRP064894 CAMK2A 815 RNAseq 1.2636 0.0000
SRP133303 CAMK2A 815 RNAseq 1.2051 0.0184
SRP159526 CAMK2A 815 RNAseq 0.3303 0.5978
SRP219564 CAMK2A 815 RNAseq -0.2062 0.7768
TCGA CAMK2A 815 RNAseq -0.0299 0.9444

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by CAMK2A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CAMK2A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CAMK2A 815 1 12 17
GSE20123 CAMK2A 815 1 12 17
GSE43470 CAMK2A 815 1 10 32
GSE46452 CAMK2A 815 0 27 32
GSE47630 CAMK2A 815 0 20 20
GSE54993 CAMK2A 815 9 1 60
GSE54994 CAMK2A 815 2 15 36
GSE60625 CAMK2A 815 0 0 11
GSE74703 CAMK2A 815 1 7 28
GSE74704 CAMK2A 815 1 7 12
TCGA CAMK2A 815 5 38 53

Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.  

 

Somatic mutations of CAMK2A:

 

Generating mutation plots.

 

Highly correlated genes for CAMK2A:

 

Showing top 20/898 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CAMK2AMAFF0.719568403
CAMK2AMUC5AC0.706518505
CAMK2AOR10H30.692892807
CAMK2AARHGEF260.689136303
CAMK2ARABEP20.686716403
CAMK2ACDH70.679435403
CAMK2ADTNA0.673914706
CAMK2ACADM20.672303303
CAMK2AASCL30.672231706
CAMK2ANR6A10.670718303
CAMK2AGRIA10.666062503
CAMK2ACBLN10.660009604
CAMK2AKIAA16140.659369605
CAMK2AAKAP60.656591807
CAMK2AULK40.656174303
CAMK2ASTBD10.653543303
CAMK2AIQUB0.651947404
CAMK2AFRMD10.651431706
CAMK2AGLI20.651303303
CAMK2ANXPE40.651214606

For details and further investigation, click here