| Full name: xylosyltransferase 2 | Alias Symbol: XT-II|PXYLT2 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 64132 | HGNC ID: HGNC:15517 | Ensembl Gene: ENSG00000015532 | OMIM ID: 608125 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of XYLT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XYLT2 | 64132 | 219401_at | 0.5298 | 0.1768 | |
| GSE20347 | XYLT2 | 64132 | 219401_at | 0.4431 | 0.0002 | |
| GSE23400 | XYLT2 | 64132 | 219401_at | 0.4214 | 0.0000 | |
| GSE26886 | XYLT2 | 64132 | 219401_at | 0.9793 | 0.0001 | |
| GSE29001 | XYLT2 | 64132 | 219401_at | 0.5120 | 0.0093 | |
| GSE38129 | XYLT2 | 64132 | 219401_at | 0.2904 | 0.0570 | |
| GSE45670 | XYLT2 | 64132 | 219401_at | 0.4074 | 0.0396 | |
| GSE53622 | XYLT2 | 64132 | 53091 | 0.6710 | 0.0000 | |
| GSE53624 | XYLT2 | 64132 | 53091 | 0.7371 | 0.0000 | |
| GSE63941 | XYLT2 | 64132 | 219401_at | -0.4202 | 0.1961 | |
| GSE77861 | XYLT2 | 64132 | 219401_at | 0.2051 | 0.2843 | |
| GSE97050 | XYLT2 | 64132 | A_23_P15582 | 0.2313 | 0.2652 | |
| SRP007169 | XYLT2 | 64132 | RNAseq | 1.0048 | 0.0426 | |
| SRP008496 | XYLT2 | 64132 | RNAseq | 1.2851 | 0.0000 | |
| SRP064894 | XYLT2 | 64132 | RNAseq | 0.9105 | 0.0003 | |
| SRP133303 | XYLT2 | 64132 | RNAseq | 0.5239 | 0.0199 | |
| SRP159526 | XYLT2 | 64132 | RNAseq | 0.7040 | 0.0150 | |
| SRP193095 | XYLT2 | 64132 | RNAseq | 0.6037 | 0.0037 | |
| SRP219564 | XYLT2 | 64132 | RNAseq | 0.6214 | 0.0101 | |
| TCGA | XYLT2 | 64132 | RNAseq | -0.4126 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by XYLT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XYLT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XYLT2 | 64132 | 5 | 2 | 23 | |
| GSE20123 | XYLT2 | 64132 | 5 | 2 | 23 | |
| GSE43470 | XYLT2 | 64132 | 3 | 2 | 38 | |
| GSE46452 | XYLT2 | 64132 | 32 | 0 | 27 | |
| GSE47630 | XYLT2 | 64132 | 9 | 0 | 31 | |
| GSE54993 | XYLT2 | 64132 | 2 | 4 | 64 | |
| GSE54994 | XYLT2 | 64132 | 9 | 6 | 38 | |
| GSE60625 | XYLT2 | 64132 | 4 | 0 | 7 | |
| GSE74703 | XYLT2 | 64132 | 3 | 2 | 31 | |
| GSE74704 | XYLT2 | 64132 | 4 | 1 | 15 | |
| TCGA | XYLT2 | 64132 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of XYLT2:
Generating mutation plots.
Highly correlated genes for XYLT2:
Showing top 20/1283 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XYLT2 | RICTOR | 0.811335 | 3 | 0 | 3 |
| XYLT2 | SPIRE1 | 0.805952 | 3 | 0 | 3 |
| XYLT2 | RNASEH2C | 0.770314 | 3 | 0 | 3 |
| XYLT2 | CAMKK1 | 0.753929 | 4 | 0 | 4 |
| XYLT2 | SNAPC2 | 0.75227 | 4 | 0 | 3 |
| XYLT2 | ZBED1 | 0.749733 | 4 | 0 | 4 |
| XYLT2 | ACY1 | 0.72683 | 3 | 0 | 3 |
| XYLT2 | RPAIN | 0.72171 | 3 | 0 | 3 |
| XYLT2 | KIAA0513 | 0.716875 | 3 | 0 | 3 |
| XYLT2 | ELFN1 | 0.714411 | 3 | 0 | 3 |
| XYLT2 | SLC35B2 | 0.711238 | 3 | 0 | 3 |
| XYLT2 | A1BG | 0.710758 | 5 | 0 | 5 |
| XYLT2 | DHX40 | 0.708473 | 3 | 0 | 3 |
| XYLT2 | SLC30A7 | 0.708072 | 3 | 0 | 3 |
| XYLT2 | RGS1 | 0.706655 | 3 | 0 | 3 |
| XYLT2 | IFNGR1 | 0.702052 | 6 | 0 | 5 |
| XYLT2 | TP53I13 | 0.700885 | 8 | 0 | 7 |
| XYLT2 | C12orf65 | 0.698956 | 4 | 0 | 4 |
| XYLT2 | TP53I11 | 0.695938 | 5 | 0 | 4 |
| XYLT2 | CCM2 | 0.694847 | 7 | 0 | 7 |
For details and further investigation, click here
