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Multi-Omics Database of ESCC

 

RPTOR

 

Full name: regulatory associated protein of MTOR complex 1 Alias Symbol: KOG1|Mip1|KIAA1303|raptor
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 57521 HGNC ID: HGNC:30287 Ensembl Gene: ENSG00000141564 OMIM ID: 607130
Drug and gene relationship at DGIdb
Screen Evidence:

 

RPTOR involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species

 

Expression of RPTOR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RPTOR 57521 225715_at 0.4332 0.2565
GSE26886 RPTOR 57521 225715_at 0.4527 0.0018
GSE45670 RPTOR 57521 225715_at 0.2262 0.0772
GSE53622 RPTOR 57521 75038 0.0582 0.6590
GSE53624 RPTOR 57521 75038 0.5073 0.0000
GSE63941 RPTOR 57521 225715_at 0.5264 0.0480
GSE77861 RPTOR 57521 225715_at 0.1714 0.2472
GSE97050 RPTOR 57521 A_23_P384499 -0.2076 0.4968
SRP007169 RPTOR 57521 RNAseq 1.4616 0.0005
SRP008496 RPTOR 57521 RNAseq 1.6534 0.0000
SRP064894 RPTOR 57521 RNAseq 0.2295 0.1247
SRP133303 RPTOR 57521 RNAseq 0.3003 0.0060
SRP159526 RPTOR 57521 RNAseq 0.3241 0.1986
SRP193095 RPTOR 57521 RNAseq 0.8131 0.0000
SRP219564 RPTOR 57521 RNAseq -0.2560 0.6277
TCGA RPTOR 57521 RNAseq -0.0439 0.3600

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by RPTOR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPTOR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RPTOR 57521 4 4 22
GSE20123 RPTOR 57521 4 4 22
GSE43470 RPTOR 57521 3 5 35
GSE46452 RPTOR 57521 34 0 25
GSE47630 RPTOR 57521 9 2 29
GSE54993 RPTOR 57521 2 5 63
GSE54994 RPTOR 57521 10 6 37
GSE60625 RPTOR 57521 6 0 5
GSE74703 RPTOR 57521 3 3 30
GSE74704 RPTOR 57521 4 3 13
TCGA RPTOR 57521 28 11 57

Total number of gains: 107; Total number of losses: 43; Total Number of normals: 338.  

 

Somatic mutations of RPTOR:

 

Generating mutation plots.

 

Highly correlated genes for RPTOR:

 

Showing top 20/608 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPTORCAMKK10.817241303
RPTORUCN0.779399303
RPTORTSPYL20.777027303
RPTORKIAA12570.756367303
RPTORPI160.754883303
RPTORPTPN140.753424303
RPTORNFAM10.753216303
RPTORSNAPC20.752749404
RPTORPCGF20.744487303
RPTORSLC46A10.741972303
RPTORADNP20.740291303
RPTORGNAI20.739533404
RPTORC15orf610.737067303
RPTORZNF1420.734477303
RPTORMRPL380.732848303
RPTORSYN30.732043303
RPTORZNF3620.723285403
RPTORGGPS10.722538403
RPTORHELZ0.717874303
RPTORZNF4960.717456403

For details and further investigation, click here