| Full name: regulatory associated protein of MTOR complex 1 | Alias Symbol: KOG1|Mip1|KIAA1303|raptor | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 57521 | HGNC ID: HGNC:30287 | Ensembl Gene: ENSG00000141564 | OMIM ID: 607130 |
| Related drugs: AZD-8055, INK-128, OSI-027... [more] | |||
Screen Evidence:
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RPTOR involved pathways:
Expression of RPTOR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPTOR | 57521 | 225715_at | 0.4332 | 0.2565 | |
| GSE26886 | RPTOR | 57521 | 225715_at | 0.4527 | 0.0018 | |
| GSE45670 | RPTOR | 57521 | 225715_at | 0.2262 | 0.0772 | |
| GSE53622 | RPTOR | 57521 | 75038 | 0.0582 | 0.6590 | |
| GSE53624 | RPTOR | 57521 | 75038 | 0.5073 | 0.0000 | |
| GSE63941 | RPTOR | 57521 | 225715_at | 0.5264 | 0.0480 | |
| GSE77861 | RPTOR | 57521 | 225715_at | 0.1714 | 0.2472 | |
| GSE97050 | RPTOR | 57521 | A_23_P384499 | -0.2076 | 0.4968 | |
| SRP007169 | RPTOR | 57521 | RNAseq | 1.4616 | 0.0005 | |
| SRP008496 | RPTOR | 57521 | RNAseq | 1.6534 | 0.0000 | |
| SRP064894 | RPTOR | 57521 | RNAseq | 0.2295 | 0.1247 | |
| SRP133303 | RPTOR | 57521 | RNAseq | 0.3003 | 0.0060 | |
| SRP159526 | RPTOR | 57521 | RNAseq | 0.3241 | 0.1986 | |
| SRP193095 | RPTOR | 57521 | RNAseq | 0.8131 | 0.0000 | |
| SRP219564 | RPTOR | 57521 | RNAseq | -0.2560 | 0.6277 | |
| TCGA | RPTOR | 57521 | RNAseq | -0.0439 | 0.3600 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RPTOR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPTOR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPTOR | 57521 | 4 | 4 | 22 | |
| GSE20123 | RPTOR | 57521 | 4 | 4 | 22 | |
| GSE43470 | RPTOR | 57521 | 3 | 5 | 35 | |
| GSE46452 | RPTOR | 57521 | 34 | 0 | 25 | |
| GSE47630 | RPTOR | 57521 | 9 | 2 | 29 | |
| GSE54993 | RPTOR | 57521 | 2 | 5 | 63 | |
| GSE54994 | RPTOR | 57521 | 10 | 6 | 37 | |
| GSE60625 | RPTOR | 57521 | 6 | 0 | 5 | |
| GSE74703 | RPTOR | 57521 | 3 | 3 | 30 | |
| GSE74704 | RPTOR | 57521 | 4 | 3 | 13 | |
| TCGA | RPTOR | 57521 | 28 | 11 | 57 |
Total number of gains: 107; Total number of losses: 43; Total Number of normals: 338.
Somatic mutations of RPTOR:
Generating mutation plots.
Highly correlated genes for RPTOR:
Showing top 20/608 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPTOR | CAMKK1 | 0.817241 | 3 | 0 | 3 |
| RPTOR | UCN | 0.779399 | 3 | 0 | 3 |
| RPTOR | TSPYL2 | 0.777027 | 3 | 0 | 3 |
| RPTOR | KIAA1257 | 0.756367 | 3 | 0 | 3 |
| RPTOR | PI16 | 0.754883 | 3 | 0 | 3 |
| RPTOR | PTPN14 | 0.753424 | 3 | 0 | 3 |
| RPTOR | NFAM1 | 0.753216 | 3 | 0 | 3 |
| RPTOR | SNAPC2 | 0.752749 | 4 | 0 | 4 |
| RPTOR | PCGF2 | 0.744487 | 3 | 0 | 3 |
| RPTOR | SLC46A1 | 0.741972 | 3 | 0 | 3 |
| RPTOR | ADNP2 | 0.740291 | 3 | 0 | 3 |
| RPTOR | GNAI2 | 0.739533 | 4 | 0 | 4 |
| RPTOR | C15orf61 | 0.737067 | 3 | 0 | 3 |
| RPTOR | ZNF142 | 0.734477 | 3 | 0 | 3 |
| RPTOR | MRPL38 | 0.732848 | 3 | 0 | 3 |
| RPTOR | SYN3 | 0.732043 | 3 | 0 | 3 |
| RPTOR | ZNF362 | 0.723285 | 4 | 0 | 3 |
| RPTOR | GGPS1 | 0.722538 | 4 | 0 | 3 |
| RPTOR | HELZ | 0.717874 | 3 | 0 | 3 |
| RPTOR | ZNF496 | 0.717456 | 4 | 0 | 3 |
For details and further investigation, click here
