| Full name: tousled like kinase 1 | Alias Symbol: KIAA0137|PKU-BETA | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 9874 | HGNC ID: HGNC:11841 | Ensembl Gene: ENSG00000198586 | OMIM ID: 608438 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TLK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLK1 | 9874 | 202606_s_at | 0.4634 | 0.2297 | |
| GSE20347 | TLK1 | 9874 | 202606_s_at | 0.5661 | 0.0063 | |
| GSE23400 | TLK1 | 9874 | 202606_s_at | 0.4300 | 0.0001 | |
| GSE26886 | TLK1 | 9874 | 202606_s_at | 0.9761 | 0.0004 | |
| GSE29001 | TLK1 | 9874 | 202606_s_at | 0.3383 | 0.3691 | |
| GSE38129 | TLK1 | 9874 | 202606_s_at | 0.3969 | 0.0103 | |
| GSE45670 | TLK1 | 9874 | 202606_s_at | 0.0826 | 0.7137 | |
| GSE53622 | TLK1 | 9874 | 49530 | 0.1886 | 0.0232 | |
| GSE53624 | TLK1 | 9874 | 49530 | 0.3866 | 0.0000 | |
| GSE63941 | TLK1 | 9874 | 202606_s_at | -0.9859 | 0.0163 | |
| GSE77861 | TLK1 | 9874 | 202606_s_at | 0.7031 | 0.0743 | |
| GSE97050 | TLK1 | 9874 | A_24_P282762 | -0.2680 | 0.4324 | |
| SRP007169 | TLK1 | 9874 | RNAseq | 0.4211 | 0.2369 | |
| SRP008496 | TLK1 | 9874 | RNAseq | 0.3515 | 0.1012 | |
| SRP064894 | TLK1 | 9874 | RNAseq | 0.1148 | 0.4751 | |
| SRP133303 | TLK1 | 9874 | RNAseq | 0.3098 | 0.0021 | |
| SRP159526 | TLK1 | 9874 | RNAseq | 0.1302 | 0.6136 | |
| SRP193095 | TLK1 | 9874 | RNAseq | 0.2902 | 0.0713 | |
| SRP219564 | TLK1 | 9874 | RNAseq | 0.0556 | 0.8971 | |
| TCGA | TLK1 | 9874 | RNAseq | -0.0300 | 0.5352 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TLK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLK1 | 9874 | 9 | 0 | 21 | |
| GSE20123 | TLK1 | 9874 | 9 | 0 | 21 | |
| GSE43470 | TLK1 | 9874 | 5 | 1 | 37 | |
| GSE46452 | TLK1 | 9874 | 1 | 4 | 54 | |
| GSE47630 | TLK1 | 9874 | 5 | 3 | 32 | |
| GSE54993 | TLK1 | 9874 | 0 | 5 | 65 | |
| GSE54994 | TLK1 | 9874 | 11 | 3 | 39 | |
| GSE60625 | TLK1 | 9874 | 0 | 3 | 8 | |
| GSE74703 | TLK1 | 9874 | 4 | 1 | 31 | |
| GSE74704 | TLK1 | 9874 | 6 | 0 | 14 | |
| TCGA | TLK1 | 9874 | 27 | 7 | 62 |
Total number of gains: 77; Total number of losses: 27; Total Number of normals: 384.
Somatic mutations of TLK1:
Generating mutation plots.
Highly correlated genes for TLK1:
Showing top 20/771 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLK1 | SGTB | 0.802063 | 4 | 0 | 4 |
| TLK1 | CAMKK1 | 0.802033 | 3 | 0 | 3 |
| TLK1 | GATAD2B | 0.740067 | 3 | 0 | 3 |
| TLK1 | ALKBH6 | 0.711936 | 4 | 0 | 4 |
| TLK1 | NIT2 | 0.710843 | 3 | 0 | 3 |
| TLK1 | C2orf69 | 0.705784 | 3 | 0 | 3 |
| TLK1 | FNIP1 | 0.687735 | 3 | 0 | 3 |
| TLK1 | PDS5B | 0.684728 | 7 | 0 | 6 |
| TLK1 | INVS | 0.684199 | 3 | 0 | 3 |
| TLK1 | LINC01116 | 0.684066 | 3 | 0 | 3 |
| TLK1 | RILPL2 | 0.679785 | 3 | 0 | 3 |
| TLK1 | METTL5 | 0.679156 | 10 | 0 | 9 |
| TLK1 | PPP1R21 | 0.677809 | 3 | 0 | 3 |
| TLK1 | ANKRD46 | 0.677409 | 4 | 0 | 3 |
| TLK1 | IL6R | 0.675098 | 4 | 0 | 3 |
| TLK1 | ATG12 | 0.673958 | 4 | 0 | 4 |
| TLK1 | USP32 | 0.673561 | 5 | 0 | 4 |
| TLK1 | ZFX | 0.67354 | 3 | 0 | 3 |
| TLK1 | XYLT2 | 0.671275 | 4 | 0 | 4 |
| TLK1 | ZNF275 | 0.669449 | 3 | 0 | 3 |
For details and further investigation, click here
