| Full name: calpain 3 | Alias Symbol: CANP3|p94|nCL-1 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 825 | HGNC ID: HGNC:1480 | Ensembl Gene: ENSG00000092529 | OMIM ID: 114240 |
| Drug and gene relationship at DGIdb | |||
Expression of CAPN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPN3 | 825 | 210944_s_at | -0.4114 | 0.5572 | |
| GSE20347 | CAPN3 | 825 | 210944_s_at | -0.6304 | 0.0050 | |
| GSE23400 | CAPN3 | 825 | 210944_s_at | -0.3119 | 0.0039 | |
| GSE26886 | CAPN3 | 825 | 210944_s_at | -0.0848 | 0.8312 | |
| GSE29001 | CAPN3 | 825 | 210944_s_at | -0.3817 | 0.3646 | |
| GSE38129 | CAPN3 | 825 | 210944_s_at | -0.5553 | 0.0015 | |
| GSE45670 | CAPN3 | 825 | 210944_s_at | -0.1983 | 0.5191 | |
| GSE63941 | CAPN3 | 825 | 210944_s_at | -0.9201 | 0.0353 | |
| GSE77861 | CAPN3 | 825 | 210944_s_at | -0.3245 | 0.0371 | |
| GSE97050 | CAPN3 | 825 | A_23_P218190 | -0.4635 | 0.1584 | |
| SRP064894 | CAPN3 | 825 | RNAseq | -0.0711 | 0.7674 | |
| SRP133303 | CAPN3 | 825 | RNAseq | -1.0683 | 0.0000 | |
| SRP159526 | CAPN3 | 825 | RNAseq | -1.2178 | 0.0098 | |
| SRP193095 | CAPN3 | 825 | RNAseq | -0.0243 | 0.9181 | |
| SRP219564 | CAPN3 | 825 | RNAseq | -0.7079 | 0.1022 | |
| TCGA | CAPN3 | 825 | RNAseq | -0.1406 | 0.4386 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CAPN3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CAPN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPN3 | 825 | 4 | 5 | 21 | |
| GSE20123 | CAPN3 | 825 | 4 | 6 | 20 | |
| GSE43470 | CAPN3 | 825 | 4 | 5 | 34 | |
| GSE46452 | CAPN3 | 825 | 3 | 7 | 49 | |
| GSE47630 | CAPN3 | 825 | 8 | 11 | 21 | |
| GSE54993 | CAPN3 | 825 | 4 | 6 | 60 | |
| GSE54994 | CAPN3 | 825 | 5 | 7 | 41 | |
| GSE60625 | CAPN3 | 825 | 4 | 0 | 7 | |
| GSE74703 | CAPN3 | 825 | 4 | 4 | 28 | |
| GSE74704 | CAPN3 | 825 | 3 | 3 | 14 | |
| TCGA | CAPN3 | 825 | 11 | 18 | 67 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of CAPN3:
Generating mutation plots.
Highly correlated genes for CAPN3:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPN3 | ENOSF1 | 0.834109 | 3 | 0 | 3 |
| CAPN3 | TMEM38A | 0.789242 | 3 | 0 | 3 |
| CAPN3 | CCDC7 | 0.788586 | 3 | 0 | 3 |
| CAPN3 | ZNF717 | 0.773699 | 3 | 0 | 3 |
| CAPN3 | KCNK2 | 0.771332 | 3 | 0 | 3 |
| CAPN3 | PARD3B | 0.746692 | 3 | 0 | 3 |
| CAPN3 | CYP4V2 | 0.741157 | 3 | 0 | 3 |
| CAPN3 | SLC35A1 | 0.739988 | 3 | 0 | 3 |
| CAPN3 | MEGF6 | 0.734577 | 3 | 0 | 3 |
| CAPN3 | SYTL4 | 0.731018 | 3 | 0 | 3 |
| CAPN3 | SAMD4B | 0.729472 | 3 | 0 | 3 |
| CAPN3 | UQCRQ | 0.724324 | 3 | 0 | 3 |
| CAPN3 | MAPK11 | 0.715875 | 3 | 0 | 3 |
| CAPN3 | XKR6 | 0.715096 | 3 | 0 | 3 |
| CAPN3 | CIDEB | 0.714423 | 4 | 0 | 3 |
| CAPN3 | KCTD21 | 0.711852 | 4 | 0 | 3 |
| CAPN3 | ANO8 | 0.704658 | 3 | 0 | 3 |
| CAPN3 | TADA2B | 0.704473 | 3 | 0 | 3 |
| CAPN3 | CACHD1 | 0.701651 | 3 | 0 | 3 |
| CAPN3 | FNBP1 | 0.700136 | 4 | 0 | 4 |
For details and further investigation, click here
