| Full name: potassium two pore domain channel subfamily K member 2 | Alias Symbol: K2p2.1|TREK-1 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 3776 | HGNC ID: HGNC:6277 | Ensembl Gene: ENSG00000082482 | OMIM ID: 603219 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNK2 | 3776 | 210261_at | -0.2946 | 0.3066 | |
| GSE20347 | KCNK2 | 3776 | 210261_at | 0.0224 | 0.8134 | |
| GSE23400 | KCNK2 | 3776 | 210261_at | -0.0426 | 0.1485 | |
| GSE26886 | KCNK2 | 3776 | 210261_at | -0.0808 | 0.3813 | |
| GSE29001 | KCNK2 | 3776 | 210261_at | -0.1051 | 0.4762 | |
| GSE38129 | KCNK2 | 3776 | 210261_at | -0.0889 | 0.2110 | |
| GSE45670 | KCNK2 | 3776 | 210261_at | -0.0104 | 0.9229 | |
| GSE53622 | KCNK2 | 3776 | 29834 | -0.3142 | 0.1553 | |
| GSE53624 | KCNK2 | 3776 | 29834 | -0.0838 | 0.6351 | |
| GSE63941 | KCNK2 | 3776 | 210261_at | 0.4018 | 0.6918 | |
| GSE77861 | KCNK2 | 3776 | 210261_at | -0.0686 | 0.4245 | |
| GSE97050 | KCNK2 | 3776 | A_33_P3213822 | -0.0136 | 0.9520 | |
| SRP133303 | KCNK2 | 3776 | RNAseq | 0.5130 | 0.0319 | |
| SRP159526 | KCNK2 | 3776 | RNAseq | 1.9974 | 0.0027 | |
| SRP193095 | KCNK2 | 3776 | RNAseq | 0.2459 | 0.2059 | |
| TCGA | KCNK2 | 3776 | RNAseq | -1.9006 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by KCNK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNK2 | 3776 | 9 | 0 | 21 | |
| GSE20123 | KCNK2 | 3776 | 9 | 0 | 21 | |
| GSE43470 | KCNK2 | 3776 | 7 | 1 | 35 | |
| GSE46452 | KCNK2 | 3776 | 3 | 1 | 55 | |
| GSE47630 | KCNK2 | 3776 | 15 | 0 | 25 | |
| GSE54993 | KCNK2 | 3776 | 0 | 6 | 64 | |
| GSE54994 | KCNK2 | 3776 | 14 | 0 | 39 | |
| GSE60625 | KCNK2 | 3776 | 0 | 0 | 11 | |
| GSE74703 | KCNK2 | 3776 | 7 | 1 | 28 | |
| GSE74704 | KCNK2 | 3776 | 3 | 0 | 17 | |
| TCGA | KCNK2 | 3776 | 44 | 3 | 49 |
Total number of gains: 111; Total number of losses: 12; Total Number of normals: 365.
Somatic mutations of KCNK2:
Generating mutation plots.
Highly correlated genes for KCNK2:
Showing top 20/637 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNK2 | GRIN3A | 0.811833 | 3 | 0 | 3 |
| KCNK2 | CAPN3 | 0.771332 | 3 | 0 | 3 |
| KCNK2 | EBF2 | 0.766512 | 4 | 0 | 4 |
| KCNK2 | SNCG | 0.763427 | 3 | 0 | 3 |
| KCNK2 | TIRAP | 0.756723 | 3 | 0 | 3 |
| KCNK2 | MAPK11 | 0.753228 | 3 | 0 | 3 |
| KCNK2 | SYDE1 | 0.751773 | 3 | 0 | 3 |
| KCNK2 | MED25 | 0.749636 | 3 | 0 | 3 |
| KCNK2 | PRELP | 0.748939 | 3 | 0 | 3 |
| KCNK2 | KDM3B | 0.745033 | 3 | 0 | 3 |
| KCNK2 | ST6GALNAC6 | 0.744027 | 3 | 0 | 3 |
| KCNK2 | CLC | 0.736699 | 3 | 0 | 3 |
| KCNK2 | STAC | 0.736406 | 3 | 0 | 3 |
| KCNK2 | RAB23 | 0.728547 | 3 | 0 | 3 |
| KCNK2 | PIP5K1C | 0.728023 | 3 | 0 | 3 |
| KCNK2 | SYNC | 0.724774 | 3 | 0 | 3 |
| KCNK2 | MXD3 | 0.724571 | 3 | 0 | 3 |
| KCNK2 | GTPBP2 | 0.723617 | 3 | 0 | 3 |
| KCNK2 | TINAGL1 | 0.722936 | 3 | 0 | 3 |
| KCNK2 | RGS14 | 0.722137 | 3 | 0 | 3 |
For details and further investigation, click here
