| Full name: ubiquinol-cytochrome c reductase complex III subunit VII | Alias Symbol: QP-C|QCR8|UQCR7 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 27089 | HGNC ID: HGNC:29594 | Ensembl Gene: ENSG00000164405 | OMIM ID: 612080 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UQCRQ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UQCRQ | 27089 | 201568_at | -0.4112 | 0.1323 | |
| GSE20347 | UQCRQ | 27089 | 201568_at | -0.7283 | 0.0000 | |
| GSE23400 | UQCRQ | 27089 | 201568_at | -0.5394 | 0.0000 | |
| GSE26886 | UQCRQ | 27089 | 201568_at | -0.2526 | 0.1004 | |
| GSE29001 | UQCRQ | 27089 | 201568_at | -0.6628 | 0.0007 | |
| GSE38129 | UQCRQ | 27089 | 201568_at | -0.5354 | 0.0000 | |
| GSE45670 | UQCRQ | 27089 | 201568_at | -0.1755 | 0.2909 | |
| GSE53622 | UQCRQ | 27089 | 96723 | -0.9104 | 0.0000 | |
| GSE53624 | UQCRQ | 27089 | 96723 | -0.4759 | 0.0000 | |
| GSE63941 | UQCRQ | 27089 | 201568_at | -0.0797 | 0.8329 | |
| GSE77861 | UQCRQ | 27089 | 201568_at | -0.8224 | 0.0057 | |
| GSE97050 | UQCRQ | 27089 | A_23_P213718 | -0.5437 | 0.1662 | |
| SRP007169 | UQCRQ | 27089 | RNAseq | -1.9578 | 0.0000 | |
| SRP008496 | UQCRQ | 27089 | RNAseq | -1.8816 | 0.0000 | |
| SRP064894 | UQCRQ | 27089 | RNAseq | -0.2187 | 0.5785 | |
| SRP133303 | UQCRQ | 27089 | RNAseq | -0.3520 | 0.0636 | |
| SRP159526 | UQCRQ | 27089 | RNAseq | -0.5191 | 0.1758 | |
| SRP193095 | UQCRQ | 27089 | RNAseq | -1.2228 | 0.0000 | |
| SRP219564 | UQCRQ | 27089 | RNAseq | -0.7960 | 0.0021 | |
| TCGA | UQCRQ | 27089 | RNAseq | -0.2438 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by UQCRQ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UQCRQ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UQCRQ | 27089 | 1 | 11 | 18 | |
| GSE20123 | UQCRQ | 27089 | 2 | 11 | 17 | |
| GSE43470 | UQCRQ | 27089 | 2 | 9 | 32 | |
| GSE46452 | UQCRQ | 27089 | 0 | 27 | 32 | |
| GSE47630 | UQCRQ | 27089 | 0 | 21 | 19 | |
| GSE54993 | UQCRQ | 27089 | 9 | 1 | 60 | |
| GSE54994 | UQCRQ | 27089 | 2 | 14 | 37 | |
| GSE60625 | UQCRQ | 27089 | 0 | 0 | 11 | |
| GSE74703 | UQCRQ | 27089 | 2 | 6 | 28 | |
| GSE74704 | UQCRQ | 27089 | 1 | 5 | 14 | |
| TCGA | UQCRQ | 27089 | 3 | 39 | 54 |
Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.
Somatic mutations of UQCRQ:
Generating mutation plots.
Highly correlated genes for UQCRQ:
Showing top 20/1220 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UQCRQ | FBXO10 | 0.776007 | 3 | 0 | 3 |
| UQCRQ | BRK1 | 0.757174 | 5 | 0 | 5 |
| UQCRQ | MRPS36 | 0.741956 | 7 | 0 | 7 |
| UQCRQ | CAPN3 | 0.724324 | 3 | 0 | 3 |
| UQCRQ | BLOC1S1 | 0.723022 | 9 | 0 | 8 |
| UQCRQ | PHYHD1 | 0.708964 | 4 | 0 | 4 |
| UQCRQ | SLC10A5 | 0.706381 | 3 | 0 | 3 |
| UQCRQ | MPI | 0.702953 | 3 | 0 | 3 |
| UQCRQ | YPEL2 | 0.700842 | 3 | 0 | 3 |
| UQCRQ | TRIM50 | 0.700575 | 3 | 0 | 3 |
| UQCRQ | HSD17B4 | 0.700354 | 13 | 0 | 13 |
| UQCRQ | FCHO2 | 0.697616 | 7 | 0 | 7 |
| UQCRQ | KIAA0355 | 0.695213 | 3 | 0 | 3 |
| UQCRQ | CA13 | 0.690548 | 3 | 0 | 3 |
| UQCRQ | ALKBH7 | 0.689652 | 5 | 0 | 3 |
| UQCRQ | ANKRD13A | 0.6889 | 6 | 0 | 5 |
| UQCRQ | TOM1L1 | 0.686621 | 3 | 0 | 3 |
| UQCRQ | NDUFA2 | 0.684083 | 13 | 0 | 11 |
| UQCRQ | RMND5B | 0.68181 | 11 | 0 | 10 |
| UQCRQ | LNX1 | 0.680984 | 5 | 0 | 5 |
For details and further investigation, click here
