| Full name: capping actin protein of muscle Z-line subunit alpha 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 829 | HGNC ID: HGNC:1488 | Ensembl Gene: ENSG00000116489 | OMIM ID: 601580 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CAPZA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPZA1 | 829 | 208374_s_at | 0.0650 | 0.9220 | |
| GSE20347 | CAPZA1 | 829 | 208374_s_at | -0.4681 | 0.0000 | |
| GSE23400 | CAPZA1 | 829 | 208374_s_at | -0.0330 | 0.7297 | |
| GSE26886 | CAPZA1 | 829 | 208374_s_at | -0.3445 | 0.0176 | |
| GSE29001 | CAPZA1 | 829 | 208374_s_at | -0.1427 | 0.5462 | |
| GSE38129 | CAPZA1 | 829 | 208374_s_at | -0.2032 | 0.2190 | |
| GSE45670 | CAPZA1 | 829 | 208374_s_at | -0.0589 | 0.6625 | |
| GSE53622 | CAPZA1 | 829 | 97600 | -0.1829 | 0.0107 | |
| GSE53624 | CAPZA1 | 829 | 97600 | -0.0988 | 0.0464 | |
| GSE63941 | CAPZA1 | 829 | 208374_s_at | -0.2429 | 0.4732 | |
| GSE77861 | CAPZA1 | 829 | 208374_s_at | -0.4382 | 0.0533 | |
| GSE97050 | CAPZA1 | 829 | A_24_P310894 | 0.0205 | 0.9713 | |
| SRP007169 | CAPZA1 | 829 | RNAseq | -1.2179 | 0.0023 | |
| SRP008496 | CAPZA1 | 829 | RNAseq | -1.3488 | 0.0000 | |
| SRP064894 | CAPZA1 | 829 | RNAseq | -0.2760 | 0.1991 | |
| SRP133303 | CAPZA1 | 829 | RNAseq | -0.0180 | 0.9193 | |
| SRP159526 | CAPZA1 | 829 | RNAseq | -0.9763 | 0.0005 | |
| SRP193095 | CAPZA1 | 829 | RNAseq | -0.7122 | 0.0000 | |
| SRP219564 | CAPZA1 | 829 | RNAseq | -0.4502 | 0.4581 | |
| TCGA | CAPZA1 | 829 | RNAseq | 0.2029 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CAPZA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPZA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPZA1 | 829 | 0 | 10 | 20 | |
| GSE20123 | CAPZA1 | 829 | 0 | 10 | 20 | |
| GSE43470 | CAPZA1 | 829 | 0 | 8 | 35 | |
| GSE46452 | CAPZA1 | 829 | 2 | 1 | 56 | |
| GSE47630 | CAPZA1 | 829 | 9 | 5 | 26 | |
| GSE54993 | CAPZA1 | 829 | 0 | 1 | 69 | |
| GSE54994 | CAPZA1 | 829 | 7 | 4 | 42 | |
| GSE60625 | CAPZA1 | 829 | 0 | 0 | 11 | |
| GSE74703 | CAPZA1 | 829 | 0 | 7 | 29 | |
| GSE74704 | CAPZA1 | 829 | 0 | 6 | 14 | |
| TCGA | CAPZA1 | 829 | 8 | 27 | 61 |
Total number of gains: 26; Total number of losses: 79; Total Number of normals: 383.
Somatic mutations of CAPZA1:
Generating mutation plots.
Highly correlated genes for CAPZA1:
Showing top 20/991 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPZA1 | ECD | 0.749619 | 3 | 0 | 3 |
| CAPZA1 | SLC22A23 | 0.749312 | 3 | 0 | 3 |
| CAPZA1 | C1GALT1C1 | 0.749038 | 3 | 0 | 3 |
| CAPZA1 | GLRX3 | 0.7458 | 3 | 0 | 3 |
| CAPZA1 | CBLC | 0.728234 | 5 | 0 | 5 |
| CAPZA1 | HLA-DPA1 | 0.71706 | 3 | 0 | 3 |
| CAPZA1 | ZDHHC5 | 0.711356 | 4 | 0 | 3 |
| CAPZA1 | KCNK6 | 0.703019 | 4 | 0 | 4 |
| CAPZA1 | TCAIM | 0.694263 | 4 | 0 | 4 |
| CAPZA1 | TWF1 | 0.690852 | 10 | 0 | 10 |
| CAPZA1 | CAPN1 | 0.689989 | 8 | 0 | 7 |
| CAPZA1 | SSU72 | 0.68985 | 4 | 0 | 4 |
| CAPZA1 | MTA2 | 0.674731 | 5 | 0 | 4 |
| CAPZA1 | RTCA | 0.672412 | 10 | 0 | 10 |
| CAPZA1 | STXBP2 | 0.670868 | 5 | 0 | 4 |
| CAPZA1 | ZNF268 | 0.668577 | 4 | 0 | 4 |
| CAPZA1 | NUP188 | 0.66782 | 4 | 0 | 3 |
| CAPZA1 | FAM83G | 0.667746 | 4 | 0 | 3 |
| CAPZA1 | FAM83B | 0.667576 | 4 | 0 | 3 |
| CAPZA1 | ACER3 | 0.666878 | 4 | 0 | 3 |
For details and further investigation, click here
