KCNK6

 

Full name: potassium two pore domain channel subfamily K member 6 Alias Symbol: K2p6.1|TWIK-2
Type: protein-coding gene Cytoband: 19q13.2
Entrez ID: 9424 HGNC ID: HGNC:6281 Ensembl Gene: ENSG00000099337 OMIM ID: 603939
Drug and gene relationship at DGIdb

 

Expression of KCNK6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KCNK6 9424 223658_at -0.6159 0.5212
GSE26886 KCNK6 9424 223658_at -1.7136 0.0000
GSE45670 KCNK6 9424 223658_at 0.3962 0.1224
GSE53622 KCNK6 9424 140708 -0.9689 0.0000
GSE53624 KCNK6 9424 140708 -1.3360 0.0000
GSE63941 KCNK6 9424 223658_at -1.1380 0.0534
GSE77861 KCNK6 9424 223658_at -0.2797 0.4438
GSE97050 KCNK6 9424 A_23_P50591 0.3115 0.6641
SRP007169 KCNK6 9424 RNAseq -1.6024 0.0001
SRP008496 KCNK6 9424 RNAseq -1.8374 0.0000
SRP064894 KCNK6 9424 RNAseq -0.8328 0.0001
SRP133303 KCNK6 9424 RNAseq -0.6646 0.0010
SRP159526 KCNK6 9424 RNAseq -1.9616 0.0000
SRP193095 KCNK6 9424 RNAseq -0.8023 0.0000
SRP219564 KCNK6 9424 RNAseq -1.3317 0.0252
TCGA KCNK6 9424 RNAseq -0.0266 0.8190

Upregulated datasets: 0; Downregulated datasets: 6.  

 

Survival by KCNK6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KCNK6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KCNK6 9424 7 4 19
GSE20123 KCNK6 9424 7 3 20
GSE43470 KCNK6 9424 4 10 29
GSE46452 KCNK6 9424 47 2 10
GSE47630 KCNK6 9424 9 5 26
GSE54993 KCNK6 9424 17 3 50
GSE54994 KCNK6 9424 6 9 38
GSE60625 KCNK6 9424 9 0 2
GSE74703 KCNK6 9424 4 6 26
GSE74704 KCNK6 9424 7 1 12
TCGA KCNK6 9424 17 15 64

Total number of gains: 134; Total number of losses: 58; Total Number of normals: 296.  

 

Somatic mutations of KCNK6:

 

Generating mutation plots.

 

Highly correlated genes for KCNK6:

 

Showing top 20/974 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KCNK6DIAPH10.799676505
KCNK6CRLF30.784875303
KCNK6HUS10.780743303
KCNK6POLD40.767025303
KCNK6TMEM190.764642404
KCNK6RALB0.763142404
KCNK6PDLIM20.756291403
KCNK6PXMP20.750366303
KCNK6EBPL0.748612303
KCNK6DAPP10.74536606
KCNK6PHF230.743437303
KCNK6GJB20.740506505
KCNK6BCL100.740201504
KCNK6SPTLC10.739516505
KCNK6PGM20.73871605
KCNK6OSTF10.732313605
KCNK6GSKIP0.731378504
KCNK6OSBPL100.730709605
KCNK6GNAI30.729151505
KCNK6PLIN30.727147707

For details and further investigation, click here