| Full name: glutaredoxin 3 | Alias Symbol: PICOT|bA500G10.4|GRX3|GLRX4|GRX4 | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 10539 | HGNC ID: HGNC:15987 | Ensembl Gene: ENSG00000108010 | OMIM ID: 612754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GLRX3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLRX3 | 10539 | 209080_x_at | 0.2352 | 0.7034 | |
| GSE20347 | GLRX3 | 10539 | 209080_x_at | 0.2470 | 0.3181 | |
| GSE23400 | GLRX3 | 10539 | 209080_x_at | 0.4272 | 0.0000 | |
| GSE26886 | GLRX3 | 10539 | 214205_x_at | -0.2631 | 0.1223 | |
| GSE29001 | GLRX3 | 10539 | 209080_x_at | 0.1660 | 0.7279 | |
| GSE38129 | GLRX3 | 10539 | 209080_x_at | 0.6774 | 0.0007 | |
| GSE45670 | GLRX3 | 10539 | 209080_x_at | 0.3074 | 0.0301 | |
| GSE53622 | GLRX3 | 10539 | 142921 | 0.2841 | 0.0000 | |
| GSE53624 | GLRX3 | 10539 | 142921 | 0.5667 | 0.0000 | |
| GSE63941 | GLRX3 | 10539 | 209080_x_at | 0.9997 | 0.0185 | |
| GSE77861 | GLRX3 | 10539 | 209080_x_at | 0.1825 | 0.5702 | |
| GSE97050 | GLRX3 | 10539 | A_24_P381029 | 0.2976 | 0.3013 | |
| SRP007169 | GLRX3 | 10539 | RNAseq | -0.1253 | 0.7550 | |
| SRP008496 | GLRX3 | 10539 | RNAseq | -0.0819 | 0.7678 | |
| SRP064894 | GLRX3 | 10539 | RNAseq | -0.0468 | 0.7491 | |
| SRP133303 | GLRX3 | 10539 | RNAseq | 0.6240 | 0.0005 | |
| SRP159526 | GLRX3 | 10539 | RNAseq | 0.2515 | 0.5432 | |
| SRP193095 | GLRX3 | 10539 | RNAseq | 0.0471 | 0.7408 | |
| SRP219564 | GLRX3 | 10539 | RNAseq | -0.0339 | 0.9141 | |
| TCGA | GLRX3 | 10539 | RNAseq | 0.2718 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GLRX3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLRX3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLRX3 | 10539 | 2 | 8 | 20 | |
| GSE20123 | GLRX3 | 10539 | 2 | 8 | 20 | |
| GSE43470 | GLRX3 | 10539 | 0 | 10 | 33 | |
| GSE46452 | GLRX3 | 10539 | 0 | 11 | 48 | |
| GSE47630 | GLRX3 | 10539 | 4 | 13 | 23 | |
| GSE54993 | GLRX3 | 10539 | 8 | 1 | 61 | |
| GSE54994 | GLRX3 | 10539 | 1 | 9 | 43 | |
| GSE60625 | GLRX3 | 10539 | 0 | 0 | 11 | |
| GSE74703 | GLRX3 | 10539 | 0 | 6 | 30 | |
| GSE74704 | GLRX3 | 10539 | 2 | 3 | 15 | |
| TCGA | GLRX3 | 10539 | 7 | 28 | 61 |
Total number of gains: 26; Total number of losses: 97; Total Number of normals: 365.
Somatic mutations of GLRX3:
Generating mutation plots.
Highly correlated genes for GLRX3:
Showing top 20/1152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLRX3 | CIB1 | 0.821931 | 3 | 0 | 3 |
| GLRX3 | COX16 | 0.772061 | 3 | 0 | 3 |
| GLRX3 | C12orf73 | 0.764891 | 3 | 0 | 3 |
| GLRX3 | LRRC59 | 0.760688 | 8 | 0 | 8 |
| GLRX3 | LRIF1 | 0.753171 | 4 | 0 | 4 |
| GLRX3 | NAA30 | 0.749656 | 3 | 0 | 3 |
| GLRX3 | CAPZA1 | 0.7458 | 3 | 0 | 3 |
| GLRX3 | PRELID1 | 0.734767 | 4 | 0 | 4 |
| GLRX3 | KLHDC2 | 0.729027 | 3 | 0 | 3 |
| GLRX3 | RAN | 0.718522 | 11 | 0 | 11 |
| GLRX3 | CPSF3 | 0.713155 | 5 | 0 | 4 |
| GLRX3 | ZFPL1 | 0.713094 | 3 | 0 | 3 |
| GLRX3 | WDR61 | 0.707646 | 7 | 0 | 7 |
| GLRX3 | AP1AR | 0.701479 | 3 | 0 | 3 |
| GLRX3 | PDE8A | 0.700422 | 3 | 0 | 3 |
| GLRX3 | BLOC1S2 | 0.69958 | 3 | 0 | 3 |
| GLRX3 | NUP37 | 0.695324 | 11 | 0 | 11 |
| GLRX3 | PIKFYVE | 0.694977 | 3 | 0 | 3 |
| GLRX3 | FARSB | 0.68798 | 4 | 0 | 4 |
| GLRX3 | EBNA1BP2 | 0.686694 | 4 | 0 | 3 |
For details and further investigation, click here
