| Full name: major histocompatibility complex, class II, DP alpha 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3113 | HGNC ID: HGNC:4938 | Ensembl Gene: ENSG00000231389 | OMIM ID: 142880 |
| Drug and gene relationship at DGIdb | |||
HLA-DPA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DPA1 | 3113 | 211990_at | -0.2586 | 0.8263 | |
| GSE20347 | HLA-DPA1 | 3113 | 211990_at | -0.5164 | 0.2162 | |
| GSE23400 | HLA-DPA1 | 3113 | 211990_at | 0.2454 | 0.2275 | |
| GSE26886 | HLA-DPA1 | 3113 | 211990_at | -0.5874 | 0.3503 | |
| GSE29001 | HLA-DPA1 | 3113 | 211990_at | 0.0445 | 0.9230 | |
| GSE38129 | HLA-DPA1 | 3113 | 211990_at | -0.4702 | 0.1860 | |
| GSE45670 | HLA-DPA1 | 3113 | 211990_at | -0.7606 | 0.1876 | |
| GSE53622 | HLA-DPA1 | 3113 | 87265 | 0.0408 | 0.7717 | |
| GSE53624 | HLA-DPA1 | 3113 | 87265 | -0.1224 | 0.3957 | |
| GSE63941 | HLA-DPA1 | 3113 | 211991_s_at | -0.2693 | 0.7173 | |
| GSE77861 | HLA-DPA1 | 3113 | 211990_at | -0.5664 | 0.2493 | |
| GSE97050 | HLA-DPA1 | 3113 | A_33_P3234277 | 0.5590 | 0.3094 | |
| SRP007169 | HLA-DPA1 | 3113 | RNAseq | 0.2557 | 0.7181 | |
| SRP008496 | HLA-DPA1 | 3113 | RNAseq | 0.0472 | 0.9236 | |
| SRP064894 | HLA-DPA1 | 3113 | RNAseq | 0.3519 | 0.2719 | |
| SRP133303 | HLA-DPA1 | 3113 | RNAseq | -0.0648 | 0.7802 | |
| SRP159526 | HLA-DPA1 | 3113 | RNAseq | -0.4983 | 0.5747 | |
| SRP193095 | HLA-DPA1 | 3113 | RNAseq | -0.2746 | 0.2296 | |
| SRP219564 | HLA-DPA1 | 3113 | RNAseq | 0.9369 | 0.0272 | |
| TCGA | HLA-DPA1 | 3113 | RNAseq | 0.0472 | 0.6962 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HLA-DPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DPA1 | 3113 | 5 | 0 | 25 | |
| GSE20123 | HLA-DPA1 | 3113 | 5 | 0 | 25 | |
| GSE43470 | HLA-DPA1 | 3113 | 4 | 1 | 38 | |
| GSE46452 | HLA-DPA1 | 3113 | 2 | 9 | 48 | |
| GSE47630 | HLA-DPA1 | 3113 | 8 | 4 | 28 | |
| GSE54993 | HLA-DPA1 | 3113 | 3 | 1 | 66 | |
| GSE54994 | HLA-DPA1 | 3113 | 11 | 4 | 38 | |
| GSE60625 | HLA-DPA1 | 3113 | 1 | 0 | 10 | |
| GSE74703 | HLA-DPA1 | 3113 | 4 | 0 | 32 | |
| GSE74704 | HLA-DPA1 | 3113 | 2 | 0 | 18 |
Total number of gains: 45; Total number of losses: 19; Total Number of normals: 328.
Somatic mutations of HLA-DPA1:
Generating mutation plots.
Highly correlated genes for HLA-DPA1:
Showing top 20/433 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DPA1 | HLA-DMA | 0.807474 | 12 | 0 | 12 |
| HLA-DPA1 | HLA-DRA | 0.806811 | 13 | 0 | 13 |
| HLA-DPA1 | CD74 | 0.794225 | 13 | 0 | 12 |
| HLA-DPA1 | HLA-DMB | 0.76541 | 13 | 0 | 12 |
| HLA-DPA1 | RNF183 | 0.75694 | 3 | 0 | 3 |
| HLA-DPA1 | TNFSF8 | 0.747408 | 4 | 0 | 4 |
| HLA-DPA1 | HLA-DPB1 | 0.746401 | 13 | 0 | 12 |
| HLA-DPA1 | MS4A6A | 0.743204 | 10 | 0 | 9 |
| HLA-DPA1 | HLA-DOA | 0.73752 | 6 | 0 | 5 |
| HLA-DPA1 | C1orf162 | 0.731856 | 7 | 0 | 7 |
| HLA-DPA1 | HLA-DQB1 | 0.730106 | 13 | 0 | 12 |
| HLA-DPA1 | ATP11C | 0.729773 | 3 | 0 | 3 |
| HLA-DPA1 | OR7E24 | 0.729109 | 3 | 0 | 3 |
| HLA-DPA1 | RPS16 | 0.718586 | 3 | 0 | 3 |
| HLA-DPA1 | CAPZA1 | 0.71706 | 3 | 0 | 3 |
| HLA-DPA1 | CERKL | 0.709439 | 3 | 0 | 3 |
| HLA-DPA1 | ARHGDIB | 0.704703 | 10 | 0 | 10 |
| HLA-DPA1 | SDHB | 0.695028 | 3 | 0 | 3 |
| HLA-DPA1 | DOCK10 | 0.691431 | 8 | 0 | 8 |
| HLA-DPA1 | CALML5 | 0.687113 | 3 | 0 | 3 |
For details and further investigation, click here
