| Full name: Cbl proto-oncogene C | Alias Symbol: CBL-3|CBL-SL|RNF57 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 23624 | HGNC ID: HGNC:15961 | Ensembl Gene: ENSG00000142273 | OMIM ID: 608453 |
| Drug and gene relationship at DGIdb | |||
CBLC involved pathways:
Expression of CBLC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBLC | 23624 | 220638_s_at | 0.2901 | 0.6955 | |
| GSE20347 | CBLC | 23624 | 220638_s_at | -0.5843 | 0.0044 | |
| GSE23400 | CBLC | 23624 | 220638_s_at | 0.0376 | 0.7283 | |
| GSE26886 | CBLC | 23624 | 220638_s_at | 0.1464 | 0.4877 | |
| GSE29001 | CBLC | 23624 | 220638_s_at | -0.2858 | 0.4074 | |
| GSE38129 | CBLC | 23624 | 220638_s_at | 0.0630 | 0.8382 | |
| GSE45670 | CBLC | 23624 | 220638_s_at | 0.5116 | 0.0271 | |
| GSE53622 | CBLC | 23624 | 88586 | -0.5460 | 0.0328 | |
| GSE53624 | CBLC | 23624 | 88586 | -0.5860 | 0.0005 | |
| GSE63941 | CBLC | 23624 | 220638_s_at | 2.6794 | 0.0016 | |
| GSE77861 | CBLC | 23624 | 223668_at | -0.0340 | 0.8139 | |
| GSE97050 | CBLC | 23624 | A_23_P397910 | -0.1580 | 0.6212 | |
| SRP007169 | CBLC | 23624 | RNAseq | -1.5072 | 0.0002 | |
| SRP008496 | CBLC | 23624 | RNAseq | -1.8392 | 0.0000 | |
| SRP064894 | CBLC | 23624 | RNAseq | -0.3665 | 0.3981 | |
| SRP133303 | CBLC | 23624 | RNAseq | 0.2169 | 0.7007 | |
| SRP159526 | CBLC | 23624 | RNAseq | -0.1097 | 0.8165 | |
| SRP193095 | CBLC | 23624 | RNAseq | -0.4927 | 0.0161 | |
| SRP219564 | CBLC | 23624 | RNAseq | -1.2447 | 0.2578 | |
| TCGA | CBLC | 23624 | RNAseq | 0.4282 | 0.0497 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CBLC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBLC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBLC | 23624 | 4 | 5 | 21 | |
| GSE20123 | CBLC | 23624 | 4 | 4 | 22 | |
| GSE43470 | CBLC | 23624 | 3 | 11 | 29 | |
| GSE46452 | CBLC | 23624 | 45 | 1 | 13 | |
| GSE47630 | CBLC | 23624 | 8 | 6 | 26 | |
| GSE54993 | CBLC | 23624 | 17 | 4 | 49 | |
| GSE54994 | CBLC | 23624 | 6 | 12 | 35 | |
| GSE60625 | CBLC | 23624 | 9 | 0 | 2 | |
| GSE74703 | CBLC | 23624 | 3 | 7 | 26 | |
| GSE74704 | CBLC | 23624 | 4 | 2 | 14 | |
| TCGA | CBLC | 23624 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of CBLC:
Generating mutation plots.
Highly correlated genes for CBLC:
Showing top 20/533 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBLC | ACTR3 | 0.819669 | 4 | 0 | 4 |
| CBLC | TRAPPC1 | 0.771233 | 3 | 0 | 3 |
| CBLC | XIAP | 0.758065 | 4 | 0 | 4 |
| CBLC | RNF149 | 0.750698 | 3 | 0 | 3 |
| CBLC | PDCD6 | 0.737237 | 3 | 0 | 3 |
| CBLC | ESR2 | 0.737233 | 3 | 0 | 3 |
| CBLC | KREMEN1 | 0.732369 | 3 | 0 | 3 |
| CBLC | YWHAE | 0.732293 | 4 | 0 | 3 |
| CBLC | CAPZA1 | 0.728234 | 5 | 0 | 5 |
| CBLC | PLEKHG1 | 0.722637 | 3 | 0 | 3 |
| CBLC | TRIM65 | 0.721317 | 3 | 0 | 3 |
| CBLC | TP63 | 0.717782 | 3 | 0 | 3 |
| CBLC | MAPK6 | 0.716382 | 4 | 0 | 4 |
| CBLC | CNOT1 | 0.712026 | 4 | 0 | 4 |
| CBLC | EIF2A | 0.710006 | 3 | 0 | 3 |
| CBLC | BAIAP2L2 | 0.701675 | 4 | 0 | 4 |
| CBLC | KDM2B | 0.699024 | 3 | 0 | 3 |
| CBLC | ZNF101 | 0.695069 | 3 | 0 | 3 |
| CBLC | CDC42EP1 | 0.693723 | 5 | 0 | 5 |
| CBLC | KIAA1522 | 0.693678 | 4 | 0 | 4 |
For details and further investigation, click here
