| Full name: calpain 1 | Alias Symbol: muCANP|muCL|CANP|CANPL1 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 823 | HGNC ID: HGNC:1476 | Ensembl Gene: ENSG00000014216 | OMIM ID: 114220 |
| Drug and gene relationship at DGIdb | |||
CAPN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa05010 | Alzheimer's disease |
Expression of CAPN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPN1 | 823 | 200752_s_at | -0.0748 | 0.9183 | |
| GSE20347 | CAPN1 | 823 | 200752_s_at | -0.9999 | 0.0000 | |
| GSE23400 | CAPN1 | 823 | 200752_s_at | -0.6537 | 0.0000 | |
| GSE26886 | CAPN1 | 823 | 200752_s_at | -1.2609 | 0.0000 | |
| GSE29001 | CAPN1 | 823 | 200752_s_at | -0.7849 | 0.0082 | |
| GSE38129 | CAPN1 | 823 | 200752_s_at | -0.5571 | 0.0469 | |
| GSE45670 | CAPN1 | 823 | 200752_s_at | -0.0147 | 0.9492 | |
| GSE53622 | CAPN1 | 823 | 96837 | -0.7773 | 0.0000 | |
| GSE53624 | CAPN1 | 823 | 96837 | -0.7820 | 0.0000 | |
| GSE63941 | CAPN1 | 823 | 200752_s_at | 1.8769 | 0.0082 | |
| GSE77861 | CAPN1 | 823 | 200752_s_at | -0.4657 | 0.0901 | |
| GSE97050 | CAPN1 | 823 | A_23_P138835 | 0.1111 | 0.8958 | |
| SRP007169 | CAPN1 | 823 | RNAseq | -2.1342 | 0.0000 | |
| SRP008496 | CAPN1 | 823 | RNAseq | -2.3210 | 0.0000 | |
| SRP064894 | CAPN1 | 823 | RNAseq | -1.1008 | 0.0000 | |
| SRP133303 | CAPN1 | 823 | RNAseq | -0.6334 | 0.0127 | |
| SRP159526 | CAPN1 | 823 | RNAseq | -1.1306 | 0.0005 | |
| SRP193095 | CAPN1 | 823 | RNAseq | -0.7165 | 0.0000 | |
| SRP219564 | CAPN1 | 823 | RNAseq | -0.9167 | 0.0650 | |
| TCGA | CAPN1 | 823 | RNAseq | 0.1341 | 0.0099 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by CAPN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPN1 | 823 | 7 | 6 | 17 | |
| GSE20123 | CAPN1 | 823 | 7 | 6 | 17 | |
| GSE43470 | CAPN1 | 823 | 4 | 1 | 38 | |
| GSE46452 | CAPN1 | 823 | 11 | 3 | 45 | |
| GSE47630 | CAPN1 | 823 | 6 | 5 | 29 | |
| GSE54993 | CAPN1 | 823 | 3 | 0 | 67 | |
| GSE54994 | CAPN1 | 823 | 6 | 5 | 42 | |
| GSE60625 | CAPN1 | 823 | 0 | 3 | 8 | |
| GSE74703 | CAPN1 | 823 | 3 | 0 | 33 | |
| GSE74704 | CAPN1 | 823 | 5 | 4 | 11 | |
| TCGA | CAPN1 | 823 | 23 | 7 | 66 |
Total number of gains: 75; Total number of losses: 40; Total Number of normals: 373.
Somatic mutations of CAPN1:
Generating mutation plots.
Highly correlated genes for CAPN1:
Showing top 20/1391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPN1 | CTNND1 | 0.790572 | 3 | 0 | 3 |
| CAPN1 | DGKA | 0.7538 | 13 | 0 | 13 |
| CAPN1 | SH3GL1 | 0.749003 | 11 | 0 | 11 |
| CAPN1 | NIPAL1 | 0.742365 | 3 | 0 | 3 |
| CAPN1 | CRABP2 | 0.740326 | 9 | 0 | 8 |
| CAPN1 | PKP3 | 0.733835 | 13 | 0 | 12 |
| CAPN1 | OTUB1 | 0.733365 | 3 | 0 | 3 |
| CAPN1 | LAD1 | 0.726261 | 13 | 0 | 13 |
| CAPN1 | CERS3 | 0.724802 | 7 | 0 | 7 |
| CAPN1 | DUOX1 | 0.722676 | 13 | 0 | 11 |
| CAPN1 | ARAP2 | 0.721065 | 3 | 0 | 3 |
| CAPN1 | GIPC1 | 0.717063 | 12 | 0 | 11 |
| CAPN1 | RARG | 0.716674 | 12 | 0 | 11 |
| CAPN1 | TRIM29 | 0.714578 | 12 | 0 | 11 |
| CAPN1 | ULK3 | 0.711565 | 7 | 0 | 7 |
| CAPN1 | EVPL | 0.711185 | 13 | 0 | 11 |
| CAPN1 | PCSK7 | 0.709968 | 8 | 0 | 7 |
| CAPN1 | MFSD5 | 0.709474 | 11 | 0 | 10 |
| CAPN1 | CKMT1A | 0.709372 | 3 | 0 | 3 |
| CAPN1 | EPGN | 0.7089 | 3 | 0 | 3 |
For details and further investigation, click here
