| Full name: caspase 5 | Alias Symbol: ICE(rel)III | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 838 | HGNC ID: HGNC:1506 | Ensembl Gene: ENSG00000137757 | OMIM ID: 602665 |
| Drug and gene relationship at DGIdb | |||
CASP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04621 | NOD-like receptor signaling pathway |
Expression of CASP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP5 | 838 | 207500_at | 0.0794 | 0.7449 | |
| GSE20347 | CASP5 | 838 | 207500_at | -0.0509 | 0.4847 | |
| GSE23400 | CASP5 | 838 | 207500_at | -0.0660 | 0.0084 | |
| GSE26886 | CASP5 | 838 | 207500_at | -0.2157 | 0.2455 | |
| GSE29001 | CASP5 | 838 | 207500_at | -0.0593 | 0.6571 | |
| GSE38129 | CASP5 | 838 | 207500_at | -0.0716 | 0.2128 | |
| GSE45670 | CASP5 | 838 | 207500_at | 0.1746 | 0.1464 | |
| GSE53622 | CASP5 | 838 | 108147 | -0.0136 | 0.8837 | |
| GSE53624 | CASP5 | 838 | 108147 | -0.3482 | 0.0001 | |
| GSE63941 | CASP5 | 838 | 207500_at | 0.1601 | 0.4684 | |
| GSE77861 | CASP5 | 838 | 207500_at | -0.1024 | 0.4006 | |
| GSE97050 | CASP5 | 838 | A_23_P47304 | 0.3670 | 0.1616 | |
| SRP133303 | CASP5 | 838 | RNAseq | 1.7364 | 0.0001 | |
| TCGA | CASP5 | 838 | RNAseq | 4.1562 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CASP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP5 | 838 | 1 | 11 | 18 | |
| GSE20123 | CASP5 | 838 | 1 | 11 | 18 | |
| GSE43470 | CASP5 | 838 | 3 | 6 | 34 | |
| GSE46452 | CASP5 | 838 | 3 | 26 | 30 | |
| GSE47630 | CASP5 | 838 | 2 | 19 | 19 | |
| GSE54993 | CASP5 | 838 | 9 | 1 | 60 | |
| GSE54994 | CASP5 | 838 | 4 | 19 | 30 | |
| GSE60625 | CASP5 | 838 | 0 | 3 | 8 | |
| GSE74703 | CASP5 | 838 | 2 | 4 | 30 | |
| GSE74704 | CASP5 | 838 | 1 | 7 | 12 | |
| TCGA | CASP5 | 838 | 9 | 44 | 43 |
Total number of gains: 35; Total number of losses: 151; Total Number of normals: 302.
Somatic mutations of CASP5:
Generating mutation plots.
Highly correlated genes for CASP5:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP5 | OR1G1 | 0.66081 | 3 | 0 | 3 |
| CASP5 | MCHR1 | 0.653844 | 4 | 0 | 4 |
| CASP5 | MYH8 | 0.638171 | 3 | 0 | 3 |
| CASP5 | PCDH11X | 0.633242 | 4 | 0 | 4 |
| CASP5 | MYO7A | 0.63177 | 3 | 0 | 3 |
| CASP5 | FCGR1B | 0.62661 | 4 | 0 | 3 |
| CASP5 | LRRC61 | 0.62008 | 3 | 0 | 3 |
| CASP5 | SPINK2 | 0.619302 | 3 | 0 | 3 |
| CASP5 | AP4S1 | 0.615585 | 5 | 0 | 4 |
| CASP5 | SUV39H2 | 0.615547 | 3 | 0 | 3 |
| CASP5 | GPR4 | 0.615279 | 4 | 0 | 3 |
| CASP5 | OR3A1 | 0.609917 | 3 | 0 | 3 |
| CASP5 | CAMK4 | 0.607542 | 3 | 0 | 3 |
| CASP5 | HRH4 | 0.599746 | 5 | 0 | 3 |
| CASP5 | SEZ6L | 0.59887 | 3 | 0 | 3 |
| CASP5 | ASCL3 | 0.597858 | 3 | 0 | 3 |
| CASP5 | MAGEA8 | 0.595046 | 3 | 0 | 3 |
| CASP5 | CGA | 0.590998 | 5 | 0 | 4 |
| CASP5 | TAS2R9 | 0.58819 | 3 | 0 | 3 |
| CASP5 | OR2S2 | 0.586782 | 4 | 0 | 3 |
For details and further investigation, click here
