| Full name: histamine receptor H4 | Alias Symbol: H4R|HH4R|AXOR35|GPCR105|GPRv53 | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 59340 | HGNC ID: HGNC:17383 | Ensembl Gene: ENSG00000134489 | OMIM ID: 606792 |
| Drug and gene relationship at DGIdb | |||
Expression of HRH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HRH4 | 59340 | 221169_s_at | -0.0215 | 0.9518 | |
| GSE20347 | HRH4 | 59340 | 221169_s_at | -0.1806 | 0.0246 | |
| GSE23400 | HRH4 | 59340 | 221169_s_at | -0.2037 | 0.0001 | |
| GSE26886 | HRH4 | 59340 | 221169_s_at | -0.2161 | 0.0358 | |
| GSE29001 | HRH4 | 59340 | 221169_s_at | -0.3631 | 0.0680 | |
| GSE38129 | HRH4 | 59340 | 221169_s_at | -0.1820 | 0.0133 | |
| GSE45670 | HRH4 | 59340 | 221169_s_at | -0.0449 | 0.7373 | |
| GSE53622 | HRH4 | 59340 | 45637 | -0.0425 | 0.8187 | |
| GSE53624 | HRH4 | 59340 | 45637 | 0.1711 | 0.2393 | |
| GSE63941 | HRH4 | 59340 | 221169_s_at | -0.0003 | 0.9986 | |
| GSE77861 | HRH4 | 59340 | 221169_s_at | -0.1145 | 0.2613 | |
| SRP133303 | HRH4 | 59340 | RNAseq | 0.4083 | 0.0275 | |
| SRP159526 | HRH4 | 59340 | RNAseq | 0.2466 | 0.6666 | |
| SRP193095 | HRH4 | 59340 | RNAseq | 0.1278 | 0.3709 | |
| TCGA | HRH4 | 59340 | RNAseq | -0.1574 | 0.7867 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HRH4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HRH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HRH4 | 59340 | 4 | 5 | 21 | |
| GSE20123 | HRH4 | 59340 | 3 | 5 | 22 | |
| GSE43470 | HRH4 | 59340 | 1 | 1 | 41 | |
| GSE46452 | HRH4 | 59340 | 3 | 24 | 32 | |
| GSE47630 | HRH4 | 59340 | 7 | 18 | 15 | |
| GSE54993 | HRH4 | 59340 | 7 | 1 | 62 | |
| GSE54994 | HRH4 | 59340 | 2 | 14 | 37 | |
| GSE60625 | HRH4 | 59340 | 0 | 4 | 7 | |
| GSE74703 | HRH4 | 59340 | 1 | 1 | 34 | |
| GSE74704 | HRH4 | 59340 | 2 | 4 | 14 | |
| TCGA | HRH4 | 59340 | 15 | 30 | 51 |
Total number of gains: 45; Total number of losses: 107; Total Number of normals: 336.
Somatic mutations of HRH4:
Generating mutation plots.
Highly correlated genes for HRH4:
Showing top 20/413 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HRH4 | OR2S2 | 0.711809 | 4 | 0 | 4 |
| HRH4 | DDX4 | 0.70305 | 3 | 0 | 3 |
| HRH4 | TGM4 | 0.680772 | 3 | 0 | 3 |
| HRH4 | XPNPEP2 | 0.67156 | 3 | 0 | 3 |
| HRH4 | UMOD | 0.667238 | 5 | 0 | 5 |
| HRH4 | POU4F3 | 0.661177 | 3 | 0 | 3 |
| HRH4 | GRIN2B | 0.659072 | 4 | 0 | 3 |
| HRH4 | ASIP | 0.658845 | 3 | 0 | 3 |
| HRH4 | NCR2 | 0.65875 | 5 | 0 | 5 |
| HRH4 | CRISP1 | 0.656175 | 4 | 0 | 3 |
| HRH4 | PRL | 0.653175 | 4 | 0 | 4 |
| HRH4 | MYO3A | 0.650939 | 3 | 0 | 3 |
| HRH4 | IL18BP | 0.64966 | 4 | 0 | 4 |
| HRH4 | SLC35F6 | 0.649333 | 5 | 0 | 4 |
| HRH4 | CPA2 | 0.647726 | 4 | 0 | 4 |
| HRH4 | GLRA3 | 0.646262 | 3 | 0 | 3 |
| HRH4 | ZNF460 | 0.643426 | 5 | 0 | 4 |
| HRH4 | CYLC1 | 0.63842 | 4 | 0 | 4 |
| HRH4 | NIPAL2 | 0.637019 | 3 | 0 | 3 |
| HRH4 | HMGN5 | 0.635939 | 4 | 0 | 4 |
For details and further investigation, click here
