| Full name: serine peptidase inhibitor, Kazal type 2 | Alias Symbol: HUSI-II | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 6691 | HGNC ID: HGNC:11245 | Ensembl Gene: ENSG00000128040 | OMIM ID: 605753 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK2 | 6691 | 206310_at | -0.1753 | 0.7212 | |
| GSE20347 | SPINK2 | 6691 | 206310_at | 0.0935 | 0.4516 | |
| GSE23400 | SPINK2 | 6691 | 206310_at | -0.1058 | 0.0434 | |
| GSE26886 | SPINK2 | 6691 | 206310_at | 0.2557 | 0.0614 | |
| GSE29001 | SPINK2 | 6691 | 206310_at | 0.0060 | 0.9761 | |
| GSE38129 | SPINK2 | 6691 | 206310_at | 0.0729 | 0.6676 | |
| GSE45670 | SPINK2 | 6691 | 206310_at | 0.1740 | 0.4018 | |
| GSE53622 | SPINK2 | 6691 | 17093 | -0.2852 | 0.2111 | |
| GSE53624 | SPINK2 | 6691 | 17093 | -0.0311 | 0.9011 | |
| GSE63941 | SPINK2 | 6691 | 206310_at | 0.8396 | 0.3220 | |
| GSE77861 | SPINK2 | 6691 | 206310_at | 0.1355 | 0.2903 | |
| GSE97050 | SPINK2 | 6691 | A_23_P155688 | 0.3254 | 0.4299 | |
| TCGA | SPINK2 | 6691 | RNAseq | 1.0767 | 0.1226 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPINK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK2 | 6691 | 3 | 12 | 15 | |
| GSE20123 | SPINK2 | 6691 | 2 | 12 | 16 | |
| GSE43470 | SPINK2 | 6691 | 0 | 14 | 29 | |
| GSE46452 | SPINK2 | 6691 | 1 | 36 | 22 | |
| GSE47630 | SPINK2 | 6691 | 0 | 19 | 21 | |
| GSE54993 | SPINK2 | 6691 | 7 | 0 | 63 | |
| GSE54994 | SPINK2 | 6691 | 2 | 10 | 41 | |
| GSE60625 | SPINK2 | 6691 | 0 | 0 | 11 | |
| GSE74703 | SPINK2 | 6691 | 0 | 12 | 24 | |
| GSE74704 | SPINK2 | 6691 | 1 | 7 | 12 | |
| TCGA | SPINK2 | 6691 | 20 | 26 | 50 |
Total number of gains: 36; Total number of losses: 148; Total Number of normals: 304.
Somatic mutations of SPINK2:
Generating mutation plots.
Highly correlated genes for SPINK2:
Showing top 20/335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK2 | KHDRBS2 | 0.732993 | 3 | 0 | 3 |
| SPINK2 | IFNA4 | 0.731809 | 4 | 0 | 4 |
| SPINK2 | B3GALT1 | 0.71514 | 3 | 0 | 3 |
| SPINK2 | RAI1 | 0.704006 | 4 | 0 | 4 |
| SPINK2 | MATN1 | 0.698711 | 3 | 0 | 3 |
| SPINK2 | GAD2 | 0.679341 | 3 | 0 | 3 |
| SPINK2 | PRAMEF12 | 0.677303 | 4 | 0 | 4 |
| SPINK2 | COLEC10 | 0.677168 | 3 | 0 | 3 |
| SPINK2 | GML | 0.676839 | 3 | 0 | 3 |
| SPINK2 | LCT | 0.673854 | 5 | 0 | 4 |
| SPINK2 | SHANK1 | 0.67259 | 3 | 0 | 3 |
| SPINK2 | P2RY4 | 0.67222 | 4 | 0 | 4 |
| SPINK2 | CYP2D6 | 0.670816 | 4 | 0 | 4 |
| SPINK2 | LINC01260 | 0.669562 | 3 | 0 | 3 |
| SPINK2 | GPD1 | 0.667185 | 4 | 0 | 3 |
| SPINK2 | SLC6A13 | 0.666741 | 4 | 0 | 4 |
| SPINK2 | TP53TG5 | 0.665253 | 3 | 0 | 3 |
| SPINK2 | CLCNKB | 0.664669 | 3 | 0 | 3 |
| SPINK2 | EDDM3A | 0.664135 | 3 | 0 | 3 |
| SPINK2 | RLBP1 | 0.664078 | 3 | 0 | 3 |
For details and further investigation, click here
