| Full name: caspase 7 | Alias Symbol: MCH3|CMH-1|ICE-LAP3 | ||
| Type: protein-coding gene | Cytoband: 10q25.3 | ||
| Entrez ID: 840 | HGNC ID: HGNC:1508 | Ensembl Gene: ENSG00000165806 | OMIM ID: 601761 |
| Drug and gene relationship at DGIdb | |||
CASP7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04668 | TNF signaling pathway | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | |
| hsa05134 | Legionellosis |
Expression of CASP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP7 | 840 | 207181_s_at | 0.7986 | 0.1935 | |
| GSE20347 | CASP7 | 840 | 207181_s_at | 0.5694 | 0.0020 | |
| GSE23400 | CASP7 | 840 | 207181_s_at | 0.5069 | 0.0000 | |
| GSE26886 | CASP7 | 840 | 207181_s_at | 0.4944 | 0.1539 | |
| GSE29001 | CASP7 | 840 | 207181_s_at | 0.8138 | 0.0005 | |
| GSE38129 | CASP7 | 840 | 207181_s_at | 0.5502 | 0.0001 | |
| GSE45670 | CASP7 | 840 | 207181_s_at | 0.9887 | 0.0002 | |
| GSE53622 | CASP7 | 840 | 43324 | 0.6024 | 0.0000 | |
| GSE53624 | CASP7 | 840 | 43324 | 0.7216 | 0.0000 | |
| GSE63941 | CASP7 | 840 | 207181_s_at | -0.2700 | 0.6120 | |
| GSE77861 | CASP7 | 840 | 207181_s_at | 0.4190 | 0.1724 | |
| GSE97050 | CASP7 | 840 | A_23_P12572 | 0.3424 | 0.2922 | |
| SRP007169 | CASP7 | 840 | RNAseq | 1.1453 | 0.0084 | |
| SRP008496 | CASP7 | 840 | RNAseq | 1.0072 | 0.0017 | |
| SRP064894 | CASP7 | 840 | RNAseq | 0.6020 | 0.0036 | |
| SRP133303 | CASP7 | 840 | RNAseq | 1.1019 | 0.0000 | |
| SRP159526 | CASP7 | 840 | RNAseq | 0.2870 | 0.4922 | |
| SRP193095 | CASP7 | 840 | RNAseq | -0.2407 | 0.3788 | |
| SRP219564 | CASP7 | 840 | RNAseq | 0.6969 | 0.0749 | |
| TCGA | CASP7 | 840 | RNAseq | -0.0482 | 0.4691 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CASP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP7 | 840 | 1 | 8 | 21 | |
| GSE20123 | CASP7 | 840 | 1 | 7 | 22 | |
| GSE43470 | CASP7 | 840 | 0 | 9 | 34 | |
| GSE46452 | CASP7 | 840 | 0 | 11 | 48 | |
| GSE47630 | CASP7 | 840 | 2 | 14 | 24 | |
| GSE54993 | CASP7 | 840 | 8 | 0 | 62 | |
| GSE54994 | CASP7 | 840 | 1 | 10 | 42 | |
| GSE60625 | CASP7 | 840 | 0 | 0 | 11 | |
| GSE74703 | CASP7 | 840 | 0 | 6 | 30 | |
| GSE74704 | CASP7 | 840 | 1 | 3 | 16 | |
| TCGA | CASP7 | 840 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of CASP7:
Generating mutation plots.
Highly correlated genes for CASP7:
Showing top 20/621 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP7 | TEX10 | 0.717487 | 3 | 0 | 3 |
| CASP7 | ZNF544 | 0.703761 | 3 | 0 | 3 |
| CASP7 | RNF149 | 0.651257 | 3 | 0 | 3 |
| CASP7 | ABHD15 | 0.64758 | 3 | 0 | 3 |
| CASP7 | IFI16 | 0.637816 | 12 | 0 | 12 |
| CASP7 | USP41 | 0.636313 | 3 | 0 | 3 |
| CASP7 | TAP1 | 0.635649 | 11 | 0 | 9 |
| CASP7 | PARP12 | 0.635056 | 11 | 0 | 10 |
| CASP7 | AGPAT5 | 0.634997 | 4 | 0 | 4 |
| CASP7 | NLRC5 | 0.63136 | 5 | 0 | 5 |
| CASP7 | NMI | 0.625193 | 13 | 0 | 10 |
| CASP7 | BRI3BP | 0.62459 | 3 | 0 | 3 |
| CASP7 | SLC1A5 | 0.623978 | 4 | 0 | 3 |
| CASP7 | GINS3 | 0.623228 | 4 | 0 | 3 |
| CASP7 | PARP14 | 0.622703 | 8 | 0 | 8 |
| CASP7 | RBM45 | 0.622413 | 4 | 0 | 3 |
| CASP7 | TRUB1 | 0.622018 | 7 | 0 | 7 |
| CASP7 | HELZ2 | 0.620895 | 4 | 0 | 3 |
| CASP7 | DDX60 | 0.617904 | 12 | 0 | 9 |
| CASP7 | UHMK1 | 0.616701 | 7 | 0 | 6 |
For details and further investigation, click here
