| Full name: NLR family CARD domain containing 5 | Alias Symbol: NOD27|CLR16.1|FLJ21709 | ||
| Type: protein-coding gene | Cytoband: 16q13 | ||
| Entrez ID: 84166 | HGNC ID: HGNC:29933 | Ensembl Gene: ENSG00000140853 | OMIM ID: 613537 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRC5 | 84166 | 226474_at | 0.8661 | 0.3147 | |
| GSE26886 | NLRC5 | 84166 | 226474_at | 0.6508 | 0.1235 | |
| GSE45670 | NLRC5 | 84166 | 226474_at | 0.8805 | 0.0141 | |
| GSE53622 | NLRC5 | 84166 | 80871 | 0.5366 | 0.0001 | |
| GSE53624 | NLRC5 | 84166 | 77685 | 0.5884 | 0.0000 | |
| GSE63941 | NLRC5 | 84166 | 226474_at | -0.0865 | 0.9223 | |
| GSE77861 | NLRC5 | 84166 | 226474_at | 0.4342 | 0.0191 | |
| GSE97050 | NLRC5 | 84166 | A_32_P416583 | 0.4967 | 0.2273 | |
| SRP007169 | NLRC5 | 84166 | RNAseq | 1.0928 | 0.0217 | |
| SRP008496 | NLRC5 | 84166 | RNAseq | 0.6586 | 0.0862 | |
| SRP064894 | NLRC5 | 84166 | RNAseq | 0.9715 | 0.0002 | |
| SRP133303 | NLRC5 | 84166 | RNAseq | 0.6199 | 0.0107 | |
| SRP159526 | NLRC5 | 84166 | RNAseq | -0.2874 | 0.5719 | |
| SRP193095 | NLRC5 | 84166 | RNAseq | 1.1177 | 0.0000 | |
| SRP219564 | NLRC5 | 84166 | RNAseq | 1.1269 | 0.0406 | |
| TCGA | NLRC5 | 84166 | RNAseq | 0.3907 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by NLRC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRC5 | 84166 | 6 | 0 | 24 | |
| GSE20123 | NLRC5 | 84166 | 6 | 1 | 23 | |
| GSE43470 | NLRC5 | 84166 | 3 | 6 | 34 | |
| GSE46452 | NLRC5 | 84166 | 38 | 1 | 20 | |
| GSE47630 | NLRC5 | 84166 | 10 | 8 | 22 | |
| GSE54993 | NLRC5 | 84166 | 2 | 4 | 64 | |
| GSE54994 | NLRC5 | 84166 | 7 | 10 | 36 | |
| GSE60625 | NLRC5 | 84166 | 4 | 0 | 7 | |
| GSE74703 | NLRC5 | 84166 | 3 | 3 | 30 | |
| GSE74704 | NLRC5 | 84166 | 5 | 0 | 15 | |
| TCGA | NLRC5 | 84166 | 25 | 13 | 58 |
Total number of gains: 109; Total number of losses: 46; Total Number of normals: 333.
Somatic mutations of NLRC5:
Generating mutation plots.
Highly correlated genes for NLRC5:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRC5 | SLC5A6 | 0.737832 | 3 | 0 | 3 |
| NLRC5 | TAP1 | 0.72116 | 6 | 0 | 5 |
| NLRC5 | PSMB10 | 0.711893 | 5 | 0 | 5 |
| NLRC5 | STAT1 | 0.709736 | 7 | 0 | 6 |
| NLRC5 | PARP12 | 0.706233 | 6 | 0 | 6 |
| NLRC5 | UBE2L6 | 0.703366 | 8 | 0 | 7 |
| NLRC5 | DHX58 | 0.701808 | 4 | 0 | 4 |
| NLRC5 | LAMP3 | 0.701442 | 6 | 0 | 6 |
| NLRC5 | IFIH1 | 0.697967 | 4 | 0 | 3 |
| NLRC5 | PSMB8 | 0.697265 | 6 | 0 | 5 |
| NLRC5 | GBP1 | 0.688968 | 7 | 0 | 5 |
| NLRC5 | APOL2 | 0.685244 | 5 | 0 | 5 |
| NLRC5 | BST2 | 0.683565 | 5 | 0 | 5 |
| NLRC5 | GZMB | 0.677084 | 7 | 0 | 6 |
| NLRC5 | XAF1 | 0.675914 | 6 | 0 | 5 |
| NLRC5 | GNLY | 0.665849 | 6 | 0 | 5 |
| NLRC5 | PSMB9 | 0.663327 | 9 | 0 | 6 |
| NLRC5 | SP110 | 0.658912 | 5 | 0 | 4 |
| NLRC5 | DDX60 | 0.657421 | 7 | 0 | 6 |
| NLRC5 | TNFRSF25 | 0.656317 | 5 | 0 | 5 |
For details and further investigation, click here
