| Full name: helicase with zinc finger 2 | Alias Symbol: PDIP1|PRIC285|KIAA1769 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 85441 | HGNC ID: HGNC:30021 | Ensembl Gene: ENSG00000130589 | OMIM ID: 611265 |
| Drug and gene relationship at DGIdb | |||
Expression of HELZ2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HELZ2 | 85441 | 228230_at | 0.5259 | 0.1720 | |
| GSE26886 | HELZ2 | 85441 | 228230_at | -0.1511 | 0.2188 | |
| GSE45670 | HELZ2 | 85441 | 228230_at | 0.7049 | 0.0013 | |
| GSE53622 | HELZ2 | 85441 | 67695 | 0.5792 | 0.0009 | |
| GSE53624 | HELZ2 | 85441 | 67695 | 1.0143 | 0.0000 | |
| GSE63941 | HELZ2 | 85441 | 228230_at | 0.4217 | 0.4962 | |
| GSE77861 | HELZ2 | 85441 | 228230_at | 0.1753 | 0.3480 | |
| SRP007169 | HELZ2 | 85441 | RNAseq | 1.2604 | 0.0435 | |
| SRP008496 | HELZ2 | 85441 | RNAseq | 0.3416 | 0.4589 | |
| SRP064894 | HELZ2 | 85441 | RNAseq | 1.1482 | 0.0001 | |
| SRP133303 | HELZ2 | 85441 | RNAseq | 0.9737 | 0.0000 | |
| SRP159526 | HELZ2 | 85441 | RNAseq | -0.3347 | 0.4752 | |
| SRP193095 | HELZ2 | 85441 | RNAseq | 0.9528 | 0.0000 | |
| SRP219564 | HELZ2 | 85441 | RNAseq | 0.2503 | 0.6533 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HELZ2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of HELZ2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HELZ2 | 85441 | 14 | 2 | 14 | |
| GSE20123 | HELZ2 | 85441 | 14 | 2 | 14 | |
| GSE43470 | HELZ2 | 85441 | 11 | 1 | 31 | |
| GSE46452 | HELZ2 | 85441 | 35 | 0 | 24 | |
| GSE47630 | HELZ2 | 85441 | 25 | 1 | 14 | |
| GSE54993 | HELZ2 | 85441 | 0 | 17 | 53 | |
| GSE54994 | HELZ2 | 85441 | 29 | 0 | 24 | |
| GSE60625 | HELZ2 | 85441 | 0 | 0 | 11 | |
| GSE74703 | HELZ2 | 85441 | 10 | 0 | 26 | |
| GSE74704 | HELZ2 | 85441 | 11 | 0 | 9 | |
| TCGA | HELZ2 | 85441 | 44 | 4 | 48 |
Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.
Somatic mutations of HELZ2:
Generating mutation plots.
Highly correlated genes for HELZ2:
Showing top 20/218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HELZ2 | DDX60L | 0.75064 | 3 | 0 | 3 |
| HELZ2 | AIM2 | 0.744603 | 4 | 0 | 4 |
| HELZ2 | ZNFX1 | 0.718972 | 6 | 0 | 6 |
| HELZ2 | OAS3 | 0.715302 | 6 | 0 | 6 |
| HELZ2 | TNFRSF25 | 0.709603 | 3 | 0 | 3 |
| HELZ2 | IRF7 | 0.709319 | 5 | 0 | 5 |
| HELZ2 | NMI | 0.706595 | 4 | 0 | 4 |
| HELZ2 | XAF1 | 0.680564 | 4 | 0 | 4 |
| HELZ2 | NCAPG | 0.678121 | 3 | 0 | 3 |
| HELZ2 | RNF213 | 0.670391 | 3 | 0 | 3 |
| HELZ2 | PLSCR1 | 0.666581 | 5 | 0 | 5 |
| HELZ2 | PARP12 | 0.66637 | 6 | 0 | 5 |
| HELZ2 | CD47 | 0.665222 | 3 | 0 | 3 |
| HELZ2 | PSMB8 | 0.664325 | 4 | 0 | 4 |
| HELZ2 | SALL4 | 0.653729 | 3 | 0 | 3 |
| HELZ2 | TRIM21 | 0.651703 | 5 | 0 | 4 |
| HELZ2 | MX1 | 0.65125 | 4 | 0 | 4 |
| HELZ2 | USP18 | 0.647445 | 6 | 0 | 6 |
| HELZ2 | MX2 | 0.645712 | 4 | 0 | 3 |
| HELZ2 | ISG15 | 0.643296 | 6 | 0 | 6 |
For details and further investigation, click here
