| Full name: GINS complex subunit 3 | Alias Symbol: FLJ13912|PSF3 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 64785 | HGNC ID: HGNC:25851 | Ensembl Gene: ENSG00000181938 | OMIM ID: 610610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GINS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GINS3 | 64785 | 218719_s_at | 0.4140 | 0.3522 | |
| GSE20347 | GINS3 | 64785 | 218719_s_at | 0.3482 | 0.0279 | |
| GSE23400 | GINS3 | 64785 | 218719_s_at | 0.1376 | 0.0146 | |
| GSE26886 | GINS3 | 64785 | 218719_s_at | -0.5219 | 0.0496 | |
| GSE29001 | GINS3 | 64785 | 45633_at | 0.4697 | 0.1103 | |
| GSE38129 | GINS3 | 64785 | 218719_s_at | 0.6332 | 0.0002 | |
| GSE45670 | GINS3 | 64785 | 218719_s_at | 0.5555 | 0.0038 | |
| GSE53622 | GINS3 | 64785 | 77343 | 0.3940 | 0.0035 | |
| GSE53624 | GINS3 | 64785 | 77343 | 0.5463 | 0.0000 | |
| GSE63941 | GINS3 | 64785 | 218719_s_at | 2.9977 | 0.0000 | |
| GSE77861 | GINS3 | 64785 | 218719_s_at | 0.1187 | 0.6690 | |
| GSE97050 | GINS3 | 64785 | A_23_P152136 | 0.6353 | 0.2467 | |
| SRP007169 | GINS3 | 64785 | RNAseq | 0.2294 | 0.5113 | |
| SRP008496 | GINS3 | 64785 | RNAseq | -0.0912 | 0.7831 | |
| SRP064894 | GINS3 | 64785 | RNAseq | 0.6535 | 0.0040 | |
| SRP133303 | GINS3 | 64785 | RNAseq | 0.4842 | 0.0131 | |
| SRP159526 | GINS3 | 64785 | RNAseq | 0.6358 | 0.0000 | |
| SRP193095 | GINS3 | 64785 | RNAseq | 0.1719 | 0.3700 | |
| SRP219564 | GINS3 | 64785 | RNAseq | 0.6607 | 0.1203 | |
| TCGA | GINS3 | 64785 | RNAseq | 0.6864 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GINS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GINS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GINS3 | 64785 | 7 | 0 | 23 | |
| GSE20123 | GINS3 | 64785 | 7 | 0 | 23 | |
| GSE43470 | GINS3 | 64785 | 2 | 7 | 34 | |
| GSE46452 | GINS3 | 64785 | 38 | 1 | 20 | |
| GSE47630 | GINS3 | 64785 | 10 | 8 | 22 | |
| GSE54993 | GINS3 | 64785 | 2 | 4 | 64 | |
| GSE54994 | GINS3 | 64785 | 6 | 10 | 37 | |
| GSE60625 | GINS3 | 64785 | 4 | 0 | 7 | |
| GSE74703 | GINS3 | 64785 | 2 | 5 | 29 | |
| GSE74704 | GINS3 | 64785 | 5 | 0 | 15 | |
| TCGA | GINS3 | 64785 | 26 | 11 | 59 |
Total number of gains: 109; Total number of losses: 46; Total Number of normals: 333.
Somatic mutations of GINS3:
Generating mutation plots.
Highly correlated genes for GINS3:
Showing top 20/1012 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GINS3 | MTFP1 | 0.793992 | 3 | 0 | 3 |
| GINS3 | PRPS2 | 0.785233 | 4 | 0 | 4 |
| GINS3 | BROX | 0.75584 | 3 | 0 | 3 |
| GINS3 | TMEM117 | 0.747796 | 3 | 0 | 3 |
| GINS3 | AASDHPPT | 0.747209 | 3 | 0 | 3 |
| GINS3 | C8orf76 | 0.743728 | 4 | 0 | 4 |
| GINS3 | CDCA2 | 0.742489 | 4 | 0 | 4 |
| GINS3 | SYNE2 | 0.740743 | 3 | 0 | 3 |
| GINS3 | PNP | 0.71113 | 4 | 0 | 3 |
| GINS3 | KDF1 | 0.710402 | 3 | 0 | 3 |
| GINS3 | PPHLN1 | 0.710121 | 3 | 0 | 3 |
| GINS3 | SRP68 | 0.70615 | 3 | 0 | 3 |
| GINS3 | ESCO2 | 0.705269 | 6 | 0 | 6 |
| GINS3 | OIP5 | 0.702181 | 6 | 0 | 6 |
| GINS3 | ZKSCAN4 | 0.698107 | 4 | 0 | 4 |
| GINS3 | APEH | 0.696166 | 3 | 0 | 3 |
| GINS3 | GUSB | 0.696025 | 3 | 0 | 3 |
| GINS3 | MAPK6 | 0.693988 | 3 | 0 | 3 |
| GINS3 | SLC16A14 | 0.692201 | 3 | 0 | 3 |
| GINS3 | STK17B | 0.691279 | 3 | 0 | 3 |
For details and further investigation, click here
