| Full name: HIC ZBTB transcriptional repressor 2 | Alias Symbol: KIAA1020|HRG22|ZBTB30|ZNF907 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 23119 | HGNC ID: HGNC:18595 | Ensembl Gene: ENSG00000169635 | OMIM ID: 607712 |
| Drug and gene relationship at DGIdb | |||
Expression of HIC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIC2 | 23119 | 212964_at | 0.1953 | 0.7995 | |
| GSE20347 | HIC2 | 23119 | 212964_at | -0.5019 | 0.0220 | |
| GSE23400 | HIC2 | 23119 | 212964_at | -0.1516 | 0.0202 | |
| GSE26886 | HIC2 | 23119 | 212964_at | -0.3078 | 0.5848 | |
| GSE29001 | HIC2 | 23119 | 212964_at | -0.4807 | 0.2133 | |
| GSE38129 | HIC2 | 23119 | 212964_at | -0.4378 | 0.0338 | |
| GSE45670 | HIC2 | 23119 | 212964_at | -0.3785 | 0.0831 | |
| GSE53622 | HIC2 | 23119 | 68944 | -0.3950 | 0.0000 | |
| GSE53624 | HIC2 | 23119 | 68944 | -1.4877 | 0.0000 | |
| GSE63941 | HIC2 | 23119 | 212964_at | 1.3744 | 0.0969 | |
| GSE77861 | HIC2 | 23119 | 216911_s_at | -0.0717 | 0.6596 | |
| GSE97050 | HIC2 | 23119 | A_33_P3379017 | -0.7321 | 0.0555 | |
| SRP007169 | HIC2 | 23119 | RNAseq | 0.2762 | 0.6420 | |
| SRP064894 | HIC2 | 23119 | RNAseq | -0.4502 | 0.0492 | |
| SRP133303 | HIC2 | 23119 | RNAseq | -0.3913 | 0.1346 | |
| SRP159526 | HIC2 | 23119 | RNAseq | -0.2754 | 0.4115 | |
| SRP193095 | HIC2 | 23119 | RNAseq | 0.0477 | 0.7568 | |
| SRP219564 | HIC2 | 23119 | RNAseq | 0.0687 | 0.8660 | |
| TCGA | HIC2 | 23119 | RNAseq | -0.1591 | 0.0767 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HIC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIC2 | 23119 | 5 | 7 | 18 | |
| GSE20123 | HIC2 | 23119 | 5 | 7 | 18 | |
| GSE43470 | HIC2 | 23119 | 3 | 7 | 33 | |
| GSE46452 | HIC2 | 23119 | 33 | 1 | 25 | |
| GSE47630 | HIC2 | 23119 | 8 | 5 | 27 | |
| GSE54993 | HIC2 | 23119 | 3 | 6 | 61 | |
| GSE54994 | HIC2 | 23119 | 11 | 7 | 35 | |
| GSE60625 | HIC2 | 23119 | 5 | 0 | 6 | |
| GSE74703 | HIC2 | 23119 | 3 | 5 | 28 | |
| GSE74704 | HIC2 | 23119 | 2 | 4 | 14 | |
| TCGA | HIC2 | 23119 | 27 | 17 | 52 |
Total number of gains: 105; Total number of losses: 66; Total Number of normals: 317.
Somatic mutations of HIC2:
Generating mutation plots.
Highly correlated genes for HIC2:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIC2 | NOC2L | 0.834829 | 3 | 0 | 3 |
| HIC2 | SLC25A10 | 0.822262 | 3 | 0 | 3 |
| HIC2 | MDH2 | 0.81574 | 3 | 0 | 3 |
| HIC2 | CASP9 | 0.795604 | 3 | 0 | 3 |
| HIC2 | CNOT10 | 0.78802 | 3 | 0 | 3 |
| HIC2 | FAM53B | 0.786411 | 3 | 0 | 3 |
| HIC2 | SND1 | 0.780685 | 3 | 0 | 3 |
| HIC2 | ZIK1 | 0.776128 | 3 | 0 | 3 |
| HIC2 | PPARG | 0.773657 | 3 | 0 | 3 |
| HIC2 | KRTAP5-10 | 0.764621 | 3 | 0 | 3 |
| HIC2 | TMEM115 | 0.758277 | 3 | 0 | 3 |
| HIC2 | LACTBL1 | 0.757233 | 3 | 0 | 3 |
| HIC2 | STX11 | 0.756052 | 3 | 0 | 3 |
| HIC2 | MOB3C | 0.749999 | 4 | 0 | 3 |
| HIC2 | TSR2 | 0.749875 | 3 | 0 | 3 |
| HIC2 | UHRF2 | 0.745335 | 3 | 0 | 3 |
| HIC2 | KMT2D | 0.744656 | 4 | 0 | 4 |
| HIC2 | ANKRD28 | 0.740939 | 3 | 0 | 3 |
| HIC2 | ACSS2 | 0.740279 | 3 | 0 | 3 |
| HIC2 | BCAS1 | 0.737265 | 3 | 0 | 3 |
For details and further investigation, click here
