CBFB

 

Full name: core-binding factor subunit beta Alias Symbol: PEBP2B
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 865 HGNC ID: HGNC:1539 Ensembl Gene: ENSG00000067955 OMIM ID: 121360
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 12/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CBFB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CBFB 865 202370_s_at 0.5246 0.2278
GSE20347 CBFB 865 202370_s_at 0.6266 0.0005
GSE23400 CBFB 865 202370_s_at 0.6853 0.0000
GSE26886 CBFB 865 202370_s_at 0.2396 0.2102
GSE29001 CBFB 865 202370_s_at 0.6789 0.0044
GSE38129 CBFB 865 202370_s_at 0.8255 0.0000
GSE45670 CBFB 865 202370_s_at 0.1714 0.3178
GSE53622 CBFB 865 91529 0.7173 0.0000
GSE53624 CBFB 865 91529 0.5006 0.0000
GSE63941 CBFB 865 202370_s_at -0.4022 0.3913
GSE77861 CBFB 865 202370_s_at 0.7400 0.0103
GSE97050 CBFB 865 A_23_P113634 0.4375 0.2641
SRP007169 CBFB 865 RNAseq 0.5352 0.1074
SRP008496 CBFB 865 RNAseq 0.7462 0.0037
SRP064894 CBFB 865 RNAseq 0.2164 0.2484
SRP133303 CBFB 865 RNAseq 0.8616 0.0000
SRP159526 CBFB 865 RNAseq 0.6731 0.0515
SRP193095 CBFB 865 RNAseq 0.5108 0.0000
SRP219564 CBFB 865 RNAseq 0.2400 0.6179
TCGA CBFB 865 RNAseq 0.3973 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CBFB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CBFB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CBFB 865 8 2 20
GSE20123 CBFB 865 8 2 20
GSE43470 CBFB 865 1 9 33
GSE46452 CBFB 865 38 1 20
GSE47630 CBFB 865 10 8 22
GSE54993 CBFB 865 2 4 64
GSE54994 CBFB 865 8 10 35
GSE60625 CBFB 865 4 0 7
GSE74703 CBFB 865 1 6 29
GSE74704 CBFB 865 5 1 14
TCGA CBFB 865 30 11 55

Total number of gains: 115; Total number of losses: 54; Total Number of normals: 319.  

 

Somatic mutations of CBFB:

 

Generating mutation plots.

 

Highly correlated genes for CBFB:

 

Showing top 20/1589 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CBFBRTKN0.76194303
CBFBMMS22L0.739286303
CBFBMMP150.733456303
CBFBC12orf660.7258303
CBFBSPNS10.720952303
CBFBIQCE0.715497303
CBFBDDB10.712129403
CBFBZCCHC170.711537303
CBFBCLEC12A0.70907303
CBFBC18orf540.704457504
CBFBHELB0.702483303
CBFBZBTB90.701857404
CBFBITGB80.699566303
CBFBDARS20.699197808
CBFBNIPA10.696408303
CBFBTRAF70.696222404
CBFBSLC30A70.69362706
CBFBPCNA0.6908491209
CBFBGINS10.68928711011
CBFBDBF40.68864511010

For details and further investigation, click here