| Full name: aspartyl-tRNA synthetase 2, mitochondrial | Alias Symbol: FLJ10514|mtAspRS | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 55157 | HGNC ID: HGNC:25538 | Ensembl Gene: ENSG00000117593 | OMIM ID: 610956 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DARS2 | 55157 | 218365_s_at | 1.0446 | 0.0739 | |
| GSE20347 | DARS2 | 55157 | 218365_s_at | 0.6917 | 0.0000 | |
| GSE23400 | DARS2 | 55157 | 218365_s_at | 0.2949 | 0.0000 | |
| GSE26886 | DARS2 | 55157 | 218365_s_at | 0.5762 | 0.0059 | |
| GSE29001 | DARS2 | 55157 | 218365_s_at | 0.0520 | 0.7977 | |
| GSE38129 | DARS2 | 55157 | 218365_s_at | 0.7901 | 0.0000 | |
| GSE45670 | DARS2 | 55157 | 218365_s_at | 0.6995 | 0.0000 | |
| GSE53622 | DARS2 | 55157 | 11868 | 1.0596 | 0.0000 | |
| GSE53624 | DARS2 | 55157 | 11868 | 1.1714 | 0.0000 | |
| GSE63941 | DARS2 | 55157 | 218365_s_at | 2.2492 | 0.0000 | |
| GSE77861 | DARS2 | 55157 | 218365_s_at | 0.5105 | 0.0198 | |
| GSE97050 | DARS2 | 55157 | A_23_P148984 | 0.6802 | 0.1242 | |
| SRP007169 | DARS2 | 55157 | RNAseq | 1.5379 | 0.0013 | |
| SRP008496 | DARS2 | 55157 | RNAseq | 1.4626 | 0.0000 | |
| SRP064894 | DARS2 | 55157 | RNAseq | 0.7890 | 0.0004 | |
| SRP133303 | DARS2 | 55157 | RNAseq | 0.8060 | 0.0000 | |
| SRP159526 | DARS2 | 55157 | RNAseq | 1.1899 | 0.0011 | |
| SRP193095 | DARS2 | 55157 | RNAseq | 0.6075 | 0.0000 | |
| SRP219564 | DARS2 | 55157 | RNAseq | 1.0642 | 0.0138 | |
| TCGA | DARS2 | 55157 | RNAseq | 0.2586 | 0.0001 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by DARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DARS2 | 55157 | 12 | 0 | 18 | |
| GSE20123 | DARS2 | 55157 | 12 | 0 | 18 | |
| GSE43470 | DARS2 | 55157 | 7 | 2 | 34 | |
| GSE46452 | DARS2 | 55157 | 3 | 1 | 55 | |
| GSE47630 | DARS2 | 55157 | 14 | 0 | 26 | |
| GSE54993 | DARS2 | 55157 | 0 | 6 | 64 | |
| GSE54994 | DARS2 | 55157 | 15 | 0 | 38 | |
| GSE60625 | DARS2 | 55157 | 0 | 0 | 11 | |
| GSE74703 | DARS2 | 55157 | 7 | 2 | 27 | |
| GSE74704 | DARS2 | 55157 | 5 | 0 | 15 | |
| TCGA | DARS2 | 55157 | 42 | 3 | 51 |
Total number of gains: 117; Total number of losses: 14; Total Number of normals: 357.
Somatic mutations of DARS2:
Generating mutation plots.
Highly correlated genes for DARS2:
Showing top 20/1846 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DARS2 | CRTC2 | 0.828484 | 3 | 0 | 3 |
| DARS2 | ALG1 | 0.784445 | 3 | 0 | 3 |
| DARS2 | NUF2 | 0.783387 | 8 | 0 | 8 |
| DARS2 | UCK2 | 0.769895 | 4 | 0 | 4 |
| DARS2 | IRF2BPL | 0.76949 | 4 | 0 | 3 |
| DARS2 | NLN | 0.763875 | 3 | 0 | 3 |
| DARS2 | NRIP1 | 0.762935 | 3 | 0 | 3 |
| DARS2 | CAPN12 | 0.760873 | 3 | 0 | 3 |
| DARS2 | UBE2C | 0.757796 | 11 | 0 | 11 |
| DARS2 | MMS22L | 0.757142 | 3 | 0 | 3 |
| DARS2 | PRELID1 | 0.754268 | 3 | 0 | 3 |
| DARS2 | BUB1 | 0.752293 | 10 | 0 | 9 |
| DARS2 | CBL | 0.752017 | 4 | 0 | 3 |
| DARS2 | TPX2 | 0.751068 | 11 | 0 | 10 |
| DARS2 | FAM89A | 0.750228 | 3 | 0 | 3 |
| DARS2 | DDX41 | 0.748105 | 3 | 0 | 3 |
| DARS2 | CKS1B | 0.747655 | 11 | 0 | 11 |
| DARS2 | GINS1 | 0.744547 | 11 | 0 | 10 |
| DARS2 | INTS3 | 0.743084 | 4 | 0 | 4 |
| DARS2 | KIF14 | 0.741012 | 10 | 0 | 10 |
For details and further investigation, click here
