PCNA

 

Full name: proliferating cell nuclear antigen Alias Symbol: 
Type: protein-coding gene Cytoband: 20p12.3
Entrez ID: 5111 HGNC ID: HGNC:8729 Ensembl Gene: ENSG00000132646 OMIM ID: 176740
Drug and gene relationship at DGIdb

 

PCNA involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa05161Hepatitis B
hsa05166HTLV-I infection

 

Expression of PCNA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PCNA 5111 201202_at 0.8361 0.1185
GSE20347 PCNA 5111 201202_at 1.0798 0.0000
GSE23400 PCNA 5111 201202_at 1.3663 0.0000
GSE26886 PCNA 5111 201202_at 0.8178 0.0011
GSE29001 PCNA 5111 201202_at 1.0743 0.0100
GSE38129 PCNA 5111 201202_at 1.3746 0.0000
GSE45670 PCNA 5111 201202_at 0.8534 0.0006
GSE53622 PCNA 5111 102034 1.1983 0.0000
GSE53624 PCNA 5111 102034 1.2859 0.0000
GSE63941 PCNA 5111 201202_at 1.5630 0.0031
GSE77861 PCNA 5111 201202_at 0.7018 0.0115
GSE97050 PCNA 5111 A_23_P28886 1.2481 0.0996
SRP007169 PCNA 5111 RNAseq 0.2815 0.4441
SRP008496 PCNA 5111 RNAseq 0.5146 0.0340
SRP064894 PCNA 5111 RNAseq 1.1181 0.0001
SRP133303 PCNA 5111 RNAseq 1.0130 0.0000
SRP159526 PCNA 5111 RNAseq 0.8935 0.0025
SRP193095 PCNA 5111 RNAseq 0.5040 0.0020
SRP219564 PCNA 5111 RNAseq 1.1817 0.0009
TCGA PCNA 5111 RNAseq 0.5348 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by PCNA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PCNA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PCNA 5111 10 3 17
GSE20123 PCNA 5111 10 3 17
GSE43470 PCNA 5111 10 1 32
GSE46452 PCNA 5111 26 1 32
GSE47630 PCNA 5111 18 4 18
GSE54993 PCNA 5111 2 14 54
GSE54994 PCNA 5111 25 2 26
GSE60625 PCNA 5111 0 0 11
GSE74703 PCNA 5111 9 1 26
GSE74704 PCNA 5111 5 1 14
TCGA PCNA 5111 40 11 45

Total number of gains: 155; Total number of losses: 41; Total Number of normals: 292.  

 

Somatic mutations of PCNA:

 

Generating mutation plots.

 

Highly correlated genes for PCNA:

 

Showing top 20/1817 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PCNAGINS10.8764912012
PCNAMCM60.8093413013
PCNATPX20.80061313013
PCNAMMS22L0.793394303
PCNADTL0.79118213013
PCNAGMNN0.79052313013
PCNACCNB20.78943412012
PCNACENPF0.78559312012
PCNAMCM20.7825312012
PCNARFC40.78068313013
PCNANCAPG20.77728712012
PCNAUBE2C0.77549613013
PCNAACTL6A0.7725512012
PCNARPA30.77234813013
PCNACKS1B0.77135113013
PCNACKAP2L0.770898707
PCNATIMELESS0.76941113013
PCNAPBK0.7680912011
PCNAGINS20.76718212012
PCNACEP550.76676712011

For details and further investigation, click here