GINS1

 

Full name: GINS complex subunit 1 Alias Symbol: KIAA0186|PSF1
Type: protein-coding gene Cytoband: 20p11.21
Entrez ID: 9837 HGNC ID: HGNC:28980 Ensembl Gene: ENSG00000101003 OMIM ID: 610608
Drug and gene relationship at DGIdb

 

Expression of GINS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GINS1 9837 206102_at 1.9514 0.0400
GSE20347 GINS1 9837 206102_at 1.5579 0.0000
GSE23400 GINS1 9837 206102_at 1.7101 0.0000
GSE26886 GINS1 9837 206102_at 0.9238 0.0015
GSE29001 GINS1 9837 206102_at 1.5606 0.0001
GSE38129 GINS1 9837 206102_at 2.0352 0.0000
GSE45670 GINS1 9837 206102_at 1.4119 0.0000
GSE53622 GINS1 9837 105599 1.3449 0.0000
GSE53624 GINS1 9837 105599 1.6653 0.0000
GSE63941 GINS1 9837 206102_at 3.0973 0.0000
GSE77861 GINS1 9837 206102_at 1.2846 0.0013
GSE97050 GINS1 9837 A_33_P3340025 1.0763 0.1239
SRP007169 GINS1 9837 RNAseq 1.2860 0.0158
SRP008496 GINS1 9837 RNAseq 1.4727 0.0001
SRP064894 GINS1 9837 RNAseq 1.2241 0.0001
SRP133303 GINS1 9837 RNAseq 1.1700 0.0000
SRP159526 GINS1 9837 RNAseq 1.5451 0.0001
SRP193095 GINS1 9837 RNAseq 0.8658 0.0000
SRP219564 GINS1 9837 RNAseq 1.7736 0.0053
TCGA GINS1 9837 RNAseq 1.0840 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  


 

Survival by GINS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of GINS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GINS1 9837 12 2 16
GSE20123 GINS1 9837 12 2 16
GSE43470 GINS1 9837 11 1 31
GSE46452 GINS1 9837 27 1 31
GSE47630 GINS1 9837 17 4 19
GSE54993 GINS1 9837 0 17 53
GSE54994 GINS1 9837 27 1 25
GSE60625 GINS1 9837 0 0 11
GSE74703 GINS1 9837 10 1 25
GSE74704 GINS1 9837 7 1 12
TCGA GINS1 9837 46 9 41

Total number of gains: 169; Total number of losses: 39; Total Number of normals: 280.  


 

Somatic mutations of GINS1:

 

Generating mutation plots.

 

Highly correlated genes for GINS1:

 

Showing top 20/2062 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GINS1PCNA0.8764912012
GINS1DTL0.8637112012
GINS1TPX20.85541612012
GINS1UBE2C0.8515512012
GINS1CENPF0.846212012
GINS1CCNB20.8460611011
GINS1TTK0.84081612012
GINS1NEK20.84011512012
GINS1AURKA0.83997812012
GINS1TIMELESS0.8395212011
GINS1FANCI0.83795112012
GINS1CDKN30.83478112012
GINS1CDCA20.834054606
GINS1RACGAP10.83396810010
GINS1UBE2T0.831818808
GINS1TOP2A0.83172312011
GINS1MCM20.83121311011
GINS1BUB1B0.831083909
GINS1NUF20.829483808
GINS1ORC60.82831711011

For details and further investigation, click here