| Full name: GINS complex subunit 1 | Alias Symbol: KIAA0186|PSF1 | ||
| Type: protein-coding gene | Cytoband: 20p11.21 | ||
| Entrez ID: 9837 | HGNC ID: HGNC:28980 | Ensembl Gene: ENSG00000101003 | OMIM ID: 610608 |
| Drug and gene relationship at DGIdb | |||
Expression of GINS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GINS1 | 9837 | 206102_at | 1.9514 | 0.0400 | |
| GSE20347 | GINS1 | 9837 | 206102_at | 1.5579 | 0.0000 | |
| GSE23400 | GINS1 | 9837 | 206102_at | 1.7101 | 0.0000 | |
| GSE26886 | GINS1 | 9837 | 206102_at | 0.9238 | 0.0015 | |
| GSE29001 | GINS1 | 9837 | 206102_at | 1.5606 | 0.0001 | |
| GSE38129 | GINS1 | 9837 | 206102_at | 2.0352 | 0.0000 | |
| GSE45670 | GINS1 | 9837 | 206102_at | 1.4119 | 0.0000 | |
| GSE53622 | GINS1 | 9837 | 105599 | 1.3449 | 0.0000 | |
| GSE53624 | GINS1 | 9837 | 105599 | 1.6653 | 0.0000 | |
| GSE63941 | GINS1 | 9837 | 206102_at | 3.0973 | 0.0000 | |
| GSE77861 | GINS1 | 9837 | 206102_at | 1.2846 | 0.0013 | |
| GSE97050 | GINS1 | 9837 | A_33_P3340025 | 1.0763 | 0.1239 | |
| SRP007169 | GINS1 | 9837 | RNAseq | 1.2860 | 0.0158 | |
| SRP008496 | GINS1 | 9837 | RNAseq | 1.4727 | 0.0001 | |
| SRP064894 | GINS1 | 9837 | RNAseq | 1.2241 | 0.0001 | |
| SRP133303 | GINS1 | 9837 | RNAseq | 1.1700 | 0.0000 | |
| SRP159526 | GINS1 | 9837 | RNAseq | 1.5451 | 0.0001 | |
| SRP193095 | GINS1 | 9837 | RNAseq | 0.8658 | 0.0000 | |
| SRP219564 | GINS1 | 9837 | RNAseq | 1.7736 | 0.0053 | |
| TCGA | GINS1 | 9837 | RNAseq | 1.0840 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by GINS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GINS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GINS1 | 9837 | 12 | 2 | 16 | |
| GSE20123 | GINS1 | 9837 | 12 | 2 | 16 | |
| GSE43470 | GINS1 | 9837 | 11 | 1 | 31 | |
| GSE46452 | GINS1 | 9837 | 27 | 1 | 31 | |
| GSE47630 | GINS1 | 9837 | 17 | 4 | 19 | |
| GSE54993 | GINS1 | 9837 | 0 | 17 | 53 | |
| GSE54994 | GINS1 | 9837 | 27 | 1 | 25 | |
| GSE60625 | GINS1 | 9837 | 0 | 0 | 11 | |
| GSE74703 | GINS1 | 9837 | 10 | 1 | 25 | |
| GSE74704 | GINS1 | 9837 | 7 | 1 | 12 | |
| TCGA | GINS1 | 9837 | 46 | 9 | 41 |
Total number of gains: 169; Total number of losses: 39; Total Number of normals: 280.
Somatic mutations of GINS1:
Generating mutation plots.
Highly correlated genes for GINS1:
Showing top 20/2062 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GINS1 | PCNA | 0.87649 | 12 | 0 | 12 |
| GINS1 | DTL | 0.86371 | 12 | 0 | 12 |
| GINS1 | TPX2 | 0.855416 | 12 | 0 | 12 |
| GINS1 | UBE2C | 0.85155 | 12 | 0 | 12 |
| GINS1 | CENPF | 0.8462 | 12 | 0 | 12 |
| GINS1 | CCNB2 | 0.84606 | 11 | 0 | 11 |
| GINS1 | TTK | 0.840816 | 12 | 0 | 12 |
| GINS1 | NEK2 | 0.840115 | 12 | 0 | 12 |
| GINS1 | AURKA | 0.839978 | 12 | 0 | 12 |
| GINS1 | TIMELESS | 0.83952 | 12 | 0 | 11 |
| GINS1 | FANCI | 0.837951 | 12 | 0 | 12 |
| GINS1 | CDKN3 | 0.834781 | 12 | 0 | 12 |
| GINS1 | CDCA2 | 0.834054 | 6 | 0 | 6 |
| GINS1 | RACGAP1 | 0.833968 | 10 | 0 | 10 |
| GINS1 | UBE2T | 0.831818 | 8 | 0 | 8 |
| GINS1 | TOP2A | 0.831723 | 12 | 0 | 11 |
| GINS1 | MCM2 | 0.831213 | 11 | 0 | 11 |
| GINS1 | BUB1B | 0.831083 | 9 | 0 | 9 |
| GINS1 | NUF2 | 0.829483 | 8 | 0 | 8 |
| GINS1 | ORC6 | 0.828317 | 11 | 0 | 11 |
For details and further investigation, click here
