| Full name: DBF4 zinc finger | Alias Symbol: ASK|chif|ZDBF1|DBF4A | ||
| Type: protein-coding gene | Cytoband: 7q21.12 | ||
| Entrez ID: 10926 | HGNC ID: HGNC:17364 | Ensembl Gene: ENSG00000006634 | OMIM ID: 604281 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DBF4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of DBF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DBF4 | 10926 | 204244_s_at | 0.9927 | 0.1720 | |
| GSE20347 | DBF4 | 10926 | 204244_s_at | 1.3481 | 0.0000 | |
| GSE23400 | DBF4 | 10926 | 204244_s_at | 0.9010 | 0.0000 | |
| GSE26886 | DBF4 | 10926 | 204244_s_at | 1.0764 | 0.0000 | |
| GSE29001 | DBF4 | 10926 | 204244_s_at | 1.2167 | 0.0033 | |
| GSE38129 | DBF4 | 10926 | 204244_s_at | 1.7079 | 0.0000 | |
| GSE45670 | DBF4 | 10926 | 204244_s_at | 1.1427 | 0.0000 | |
| GSE53622 | DBF4 | 10926 | 31715 | 1.0668 | 0.0000 | |
| GSE53624 | DBF4 | 10926 | 31715 | 1.0199 | 0.0000 | |
| GSE63941 | DBF4 | 10926 | 204244_s_at | 1.5573 | 0.0124 | |
| GSE77861 | DBF4 | 10926 | 204244_s_at | 0.8207 | 0.0146 | |
| GSE97050 | DBF4 | 10926 | A_33_P3413523 | 0.6733 | 0.1190 | |
| SRP007169 | DBF4 | 10926 | RNAseq | 1.4860 | 0.0003 | |
| SRP008496 | DBF4 | 10926 | RNAseq | 1.5451 | 0.0000 | |
| SRP064894 | DBF4 | 10926 | RNAseq | 0.7901 | 0.0008 | |
| SRP133303 | DBF4 | 10926 | RNAseq | 1.4633 | 0.0000 | |
| SRP159526 | DBF4 | 10926 | RNAseq | 0.6909 | 0.0138 | |
| SRP193095 | DBF4 | 10926 | RNAseq | 0.9167 | 0.0000 | |
| SRP219564 | DBF4 | 10926 | RNAseq | 1.3737 | 0.0069 | |
| TCGA | DBF4 | 10926 | RNAseq | 0.5935 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by DBF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DBF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DBF4 | 10926 | 13 | 1 | 16 | |
| GSE20123 | DBF4 | 10926 | 13 | 1 | 16 | |
| GSE43470 | DBF4 | 10926 | 5 | 1 | 37 | |
| GSE46452 | DBF4 | 10926 | 12 | 0 | 47 | |
| GSE47630 | DBF4 | 10926 | 8 | 2 | 30 | |
| GSE54993 | DBF4 | 10926 | 2 | 7 | 61 | |
| GSE54994 | DBF4 | 10926 | 17 | 2 | 34 | |
| GSE60625 | DBF4 | 10926 | 0 | 0 | 11 | |
| GSE74703 | DBF4 | 10926 | 4 | 1 | 31 | |
| GSE74704 | DBF4 | 10926 | 9 | 1 | 10 | |
| TCGA | DBF4 | 10926 | 54 | 4 | 38 |
Total number of gains: 137; Total number of losses: 20; Total Number of normals: 331.
Somatic mutations of DBF4:
Generating mutation plots.
Highly correlated genes for DBF4:
Showing top 20/2079 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DBF4 | LRRC58 | 0.834997 | 4 | 0 | 4 |
| DBF4 | RACGAP1 | 0.808869 | 10 | 0 | 10 |
| DBF4 | CDCA2 | 0.805148 | 6 | 0 | 6 |
| DBF4 | BUB1 | 0.784479 | 10 | 0 | 10 |
| DBF4 | DTL | 0.783922 | 12 | 0 | 12 |
| DBF4 | MCM10 | 0.783309 | 11 | 0 | 11 |
| DBF4 | CENPF | 0.772399 | 12 | 0 | 12 |
| DBF4 | BORA | 0.770562 | 10 | 0 | 10 |
| DBF4 | C1orf112 | 0.770471 | 10 | 0 | 10 |
| DBF4 | MAGOHB | 0.768918 | 10 | 0 | 9 |
| DBF4 | GMNN | 0.766128 | 12 | 0 | 12 |
| DBF4 | FOXN2 | 0.766054 | 4 | 0 | 4 |
| DBF4 | KIF18A | 0.765478 | 12 | 0 | 12 |
| DBF4 | ASPM | 0.761622 | 12 | 0 | 11 |
| DBF4 | MTERF3 | 0.761406 | 8 | 0 | 8 |
| DBF4 | RAD51AP1 | 0.759277 | 12 | 0 | 11 |
| DBF4 | CKS1B | 0.758423 | 12 | 0 | 12 |
| DBF4 | MCM6 | 0.758384 | 12 | 0 | 12 |
| DBF4 | LSM4 | 0.757333 | 9 | 0 | 9 |
| DBF4 | UBE2T | 0.757018 | 8 | 0 | 8 |
For details and further investigation, click here
