| Full name: bone morphogenetic protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p12.3 | ||
| Entrez ID: 650 | HGNC ID: HGNC:1069 | Ensembl Gene: ENSG00000125845 | OMIM ID: 112261 |
| Drug and gene relationship at DGIdb | |||
BMP2 involved pathways:
Expression of BMP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP2 | 650 | 205290_s_at | -0.1610 | 0.9284 | |
| GSE20347 | BMP2 | 650 | 205290_s_at | 0.2555 | 0.6695 | |
| GSE23400 | BMP2 | 650 | 205290_s_at | 0.2591 | 0.1338 | |
| GSE26886 | BMP2 | 650 | 205290_s_at | 2.0663 | 0.0004 | |
| GSE29001 | BMP2 | 650 | 205290_s_at | -0.8442 | 0.1063 | |
| GSE38129 | BMP2 | 650 | 205290_s_at | 0.1138 | 0.7983 | |
| GSE45670 | BMP2 | 650 | 205290_s_at | 0.9451 | 0.1464 | |
| GSE53622 | BMP2 | 650 | 32823 | -0.0144 | 0.9504 | |
| GSE53624 | BMP2 | 650 | 32823 | -0.1935 | 0.2779 | |
| GSE63941 | BMP2 | 650 | 205289_at | -2.4976 | 0.0160 | |
| GSE77861 | BMP2 | 650 | 205290_s_at | 1.5182 | 0.0324 | |
| GSE97050 | BMP2 | 650 | A_33_P3237150 | 0.4286 | 0.2727 | |
| SRP007169 | BMP2 | 650 | RNAseq | -1.0793 | 0.0470 | |
| SRP008496 | BMP2 | 650 | RNAseq | -0.5294 | 0.2525 | |
| SRP064894 | BMP2 | 650 | RNAseq | 0.6181 | 0.1325 | |
| SRP133303 | BMP2 | 650 | RNAseq | 0.6685 | 0.0660 | |
| SRP159526 | BMP2 | 650 | RNAseq | 0.8236 | 0.0327 | |
| SRP193095 | BMP2 | 650 | RNAseq | 0.8055 | 0.0298 | |
| SRP219564 | BMP2 | 650 | RNAseq | 0.3865 | 0.4851 | |
| TCGA | BMP2 | 650 | RNAseq | -0.2264 | 0.1612 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by BMP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP2 | 650 | 11 | 1 | 18 | |
| GSE20123 | BMP2 | 650 | 11 | 1 | 18 | |
| GSE43470 | BMP2 | 650 | 12 | 1 | 30 | |
| GSE46452 | BMP2 | 650 | 26 | 1 | 32 | |
| GSE47630 | BMP2 | 650 | 18 | 4 | 18 | |
| GSE54993 | BMP2 | 650 | 1 | 14 | 55 | |
| GSE54994 | BMP2 | 650 | 25 | 2 | 26 | |
| GSE60625 | BMP2 | 650 | 0 | 0 | 11 | |
| GSE74703 | BMP2 | 650 | 9 | 1 | 26 | |
| GSE74704 | BMP2 | 650 | 5 | 1 | 14 | |
| TCGA | BMP2 | 650 | 40 | 11 | 45 |
Total number of gains: 158; Total number of losses: 37; Total Number of normals: 293.
Somatic mutations of BMP2:
Generating mutation plots.
Highly correlated genes for BMP2:
Showing top 20/576 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP2 | TMEM223 | 0.786832 | 3 | 0 | 3 |
| BMP2 | MRGBP | 0.751592 | 3 | 0 | 3 |
| BMP2 | MRPS26 | 0.751485 | 3 | 0 | 3 |
| BMP2 | LRRC8A | 0.751186 | 3 | 0 | 3 |
| BMP2 | MRPL55 | 0.741609 | 3 | 0 | 3 |
| BMP2 | CHML | 0.73851 | 3 | 0 | 3 |
| BMP2 | YWHAG | 0.737415 | 3 | 0 | 3 |
| BMP2 | ZNF827 | 0.73411 | 3 | 0 | 3 |
| BMP2 | NEK6 | 0.726581 | 3 | 0 | 3 |
| BMP2 | AGRN | 0.724633 | 4 | 0 | 4 |
| BMP2 | MOGS | 0.72447 | 3 | 0 | 3 |
| BMP2 | CCT2 | 0.722239 | 3 | 0 | 3 |
| BMP2 | MAPKAPK5 | 0.721645 | 3 | 0 | 3 |
| BMP2 | TCTN3 | 0.721428 | 3 | 0 | 3 |
| BMP2 | EXOSC6 | 0.721098 | 3 | 0 | 3 |
| BMP2 | LRRC42 | 0.716796 | 3 | 0 | 3 |
| BMP2 | SVEP1 | 0.716153 | 3 | 0 | 3 |
| BMP2 | CBX1 | 0.71595 | 3 | 0 | 3 |
| BMP2 | FJX1 | 0.714062 | 5 | 0 | 5 |
| BMP2 | SMARCAL1 | 0.713813 | 3 | 0 | 3 |
For details and further investigation, click here
