| Full name: hydroxysteroid 17-beta dehydrogenase 1 | Alias Symbol: HSD17|MGC138140|SDR28C1 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 3292 | HGNC ID: HGNC:5210 | Ensembl Gene: ENSG00000108786 | OMIM ID: 109684 |
| Drug and gene relationship at DGIdb | |||
HSD17B1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis |
Expression of HSD17B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B1 | 3292 | 228595_at | 0.2976 | 0.3522 | |
| GSE20347 | HSD17B1 | 3292 | 205829_at | -0.1223 | 0.6622 | |
| GSE23400 | HSD17B1 | 3292 | 205829_at | 0.0135 | 0.8237 | |
| GSE26886 | HSD17B1 | 3292 | 228595_at | 0.7577 | 0.0015 | |
| GSE29001 | HSD17B1 | 3292 | 205829_at | -0.1622 | 0.7120 | |
| GSE38129 | HSD17B1 | 3292 | 205829_at | 0.4139 | 0.1340 | |
| GSE45670 | HSD17B1 | 3292 | 205829_at | 0.6841 | 0.0033 | |
| GSE53622 | HSD17B1 | 3292 | 25162 | -0.1132 | 0.3984 | |
| GSE53624 | HSD17B1 | 3292 | 25162 | -0.1515 | 0.0640 | |
| GSE63941 | HSD17B1 | 3292 | 228595_at | -0.2903 | 0.3658 | |
| GSE77861 | HSD17B1 | 3292 | 228595_at | 0.4634 | 0.0249 | |
| GSE97050 | HSD17B1 | 3292 | A_23_P15542 | 0.5077 | 0.2359 | |
| SRP007169 | HSD17B1 | 3292 | RNAseq | -0.1766 | 0.7458 | |
| SRP064894 | HSD17B1 | 3292 | RNAseq | 0.1522 | 0.7443 | |
| SRP133303 | HSD17B1 | 3292 | RNAseq | 0.6263 | 0.1205 | |
| SRP159526 | HSD17B1 | 3292 | RNAseq | 1.0152 | 0.0419 | |
| SRP219564 | HSD17B1 | 3292 | RNAseq | -0.2616 | 0.6909 | |
| TCGA | HSD17B1 | 3292 | RNAseq | 0.7910 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HSD17B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B1 | 3292 | 6 | 2 | 22 | |
| GSE20123 | HSD17B1 | 3292 | 6 | 2 | 22 | |
| GSE43470 | HSD17B1 | 3292 | 1 | 2 | 40 | |
| GSE46452 | HSD17B1 | 3292 | 34 | 0 | 25 | |
| GSE47630 | HSD17B1 | 3292 | 8 | 1 | 31 | |
| GSE54993 | HSD17B1 | 3292 | 3 | 4 | 63 | |
| GSE54994 | HSD17B1 | 3292 | 8 | 5 | 40 | |
| GSE60625 | HSD17B1 | 3292 | 4 | 0 | 7 | |
| GSE74703 | HSD17B1 | 3292 | 1 | 1 | 34 | |
| GSE74704 | HSD17B1 | 3292 | 4 | 1 | 15 | |
| TCGA | HSD17B1 | 3292 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of HSD17B1:
Generating mutation plots.
Highly correlated genes for HSD17B1:
Showing top 20/828 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B1 | HOXD8 | 0.824592 | 3 | 0 | 3 |
| HSD17B1 | GMCL1 | 0.750901 | 3 | 0 | 3 |
| HSD17B1 | BLACAT1 | 0.739459 | 3 | 0 | 3 |
| HSD17B1 | PDE7A | 0.734005 | 3 | 0 | 3 |
| HSD17B1 | CBX1 | 0.730313 | 3 | 0 | 3 |
| HSD17B1 | NAV1 | 0.729742 | 4 | 0 | 4 |
| HSD17B1 | BCAS3 | 0.717598 | 3 | 0 | 3 |
| HSD17B1 | C12orf60 | 0.717367 | 4 | 0 | 4 |
| HSD17B1 | RBP1 | 0.715936 | 4 | 0 | 4 |
| HSD17B1 | KIAA1324L | 0.714388 | 3 | 0 | 3 |
| HSD17B1 | TUBG1 | 0.714036 | 6 | 0 | 5 |
| HSD17B1 | CFL1 | 0.711696 | 4 | 0 | 4 |
| HSD17B1 | ASAP2 | 0.71141 | 3 | 0 | 3 |
| HSD17B1 | GIT1 | 0.709239 | 3 | 0 | 3 |
| HSD17B1 | EAF2 | 0.708066 | 4 | 0 | 4 |
| HSD17B1 | NACC1 | 0.707811 | 5 | 0 | 5 |
| HSD17B1 | XXYLT1 | 0.70753 | 4 | 0 | 3 |
| HSD17B1 | PKMYT1 | 0.706537 | 4 | 0 | 4 |
| HSD17B1 | CLSPN | 0.702295 | 4 | 0 | 3 |
| HSD17B1 | SPNS1 | 0.697483 | 4 | 0 | 4 |
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