| Full name: chromobox 4 | Alias Symbol: hPC2|PC2|NBP16 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 8535 | HGNC ID: HGNC:1554 | Ensembl Gene: ENSG00000141582 | OMIM ID: 603079 |
| Drug and gene relationship at DGIdb | |||
Expression of CBX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX4 | 8535 | 227558_at | -0.2000 | 0.6652 | |
| GSE20347 | CBX4 | 8535 | 206724_at | 0.0154 | 0.9061 | |
| GSE23400 | CBX4 | 8535 | 206724_at | -0.1543 | 0.0060 | |
| GSE26886 | CBX4 | 8535 | 227558_at | 0.1012 | 0.6954 | |
| GSE29001 | CBX4 | 8535 | 206724_at | -0.0654 | 0.5212 | |
| GSE38129 | CBX4 | 8535 | 206724_at | 0.0675 | 0.5085 | |
| GSE45670 | CBX4 | 8535 | 227558_at | 0.0870 | 0.7430 | |
| GSE53622 | CBX4 | 8535 | 12838 | 0.0487 | 0.5481 | |
| GSE53624 | CBX4 | 8535 | 57944 | 0.1616 | 0.0135 | |
| GSE63941 | CBX4 | 8535 | 227558_at | 1.9935 | 0.0059 | |
| GSE77861 | CBX4 | 8535 | 227558_at | 0.4722 | 0.3093 | |
| GSE97050 | CBX4 | 8535 | A_23_P89621 | 0.0893 | 0.6907 | |
| SRP007169 | CBX4 | 8535 | RNAseq | -1.3524 | 0.0042 | |
| SRP008496 | CBX4 | 8535 | RNAseq | -1.0292 | 0.0009 | |
| SRP064894 | CBX4 | 8535 | RNAseq | -0.7192 | 0.0012 | |
| SRP133303 | CBX4 | 8535 | RNAseq | 0.1593 | 0.3830 | |
| SRP159526 | CBX4 | 8535 | RNAseq | 0.1634 | 0.5157 | |
| SRP193095 | CBX4 | 8535 | RNAseq | 0.3934 | 0.0187 | |
| SRP219564 | CBX4 | 8535 | RNAseq | 0.4323 | 0.2705 | |
| TCGA | CBX4 | 8535 | RNAseq | 0.2308 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by CBX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX4 | 8535 | 4 | 3 | 23 | |
| GSE20123 | CBX4 | 8535 | 4 | 3 | 23 | |
| GSE43470 | CBX4 | 8535 | 3 | 5 | 35 | |
| GSE46452 | CBX4 | 8535 | 34 | 0 | 25 | |
| GSE47630 | CBX4 | 8535 | 9 | 1 | 30 | |
| GSE54993 | CBX4 | 8535 | 2 | 5 | 63 | |
| GSE54994 | CBX4 | 8535 | 10 | 6 | 37 | |
| GSE60625 | CBX4 | 8535 | 6 | 0 | 5 | |
| GSE74703 | CBX4 | 8535 | 3 | 3 | 30 | |
| GSE74704 | CBX4 | 8535 | 4 | 3 | 13 | |
| TCGA | CBX4 | 8535 | 29 | 9 | 58 |
Total number of gains: 108; Total number of losses: 38; Total Number of normals: 342.
Somatic mutations of CBX4:
Generating mutation plots.
Highly correlated genes for CBX4:
Showing top 20/173 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX4 | ANKRD34C | 0.701218 | 3 | 0 | 3 |
| CBX4 | KCNAB3 | 0.66867 | 4 | 0 | 4 |
| CBX4 | TGM7 | 0.668624 | 3 | 0 | 3 |
| CBX4 | JUND | 0.663093 | 3 | 0 | 3 |
| CBX4 | TMEM184A | 0.661621 | 3 | 0 | 3 |
| CBX4 | ST8SIA3 | 0.658728 | 3 | 0 | 3 |
| CBX4 | CNTN6 | 0.658527 | 4 | 0 | 4 |
| CBX4 | POM121L12 | 0.657358 | 3 | 0 | 3 |
| CBX4 | SIGLEC11 | 0.654881 | 3 | 0 | 3 |
| CBX4 | EGR1 | 0.640495 | 3 | 0 | 3 |
| CBX4 | LAT2 | 0.638719 | 3 | 0 | 3 |
| CBX4 | NPPB | 0.637999 | 3 | 0 | 3 |
| CBX4 | PIP5K1A | 0.633888 | 4 | 0 | 3 |
| CBX4 | GNRH2 | 0.630316 | 6 | 0 | 5 |
| CBX4 | FAM131C | 0.627398 | 5 | 0 | 4 |
| CBX4 | TEX33 | 0.626232 | 3 | 0 | 3 |
| CBX4 | AQP8 | 0.62552 | 3 | 0 | 3 |
| CBX4 | LCNL1 | 0.620986 | 3 | 0 | 3 |
| CBX4 | LINC00486 | 0.618583 | 3 | 0 | 3 |
| CBX4 | FUT1 | 0.611116 | 4 | 0 | 3 |
For details and further investigation, click here
