| Full name: phosphatidylinositol-4-phosphate 5-kinase type 1 alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 8394 | HGNC ID: HGNC:8994 | Ensembl Gene: ENSG00000143398 | OMIM ID: 603275 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PIP5K1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05231 | Choline metabolism in cancer |
Expression of PIP5K1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIP5K1A | 8394 | 207391_s_at | 0.3059 | 0.3765 | |
| GSE20347 | PIP5K1A | 8394 | 207391_s_at | -0.0580 | 0.4619 | |
| GSE23400 | PIP5K1A | 8394 | 207391_s_at | -0.0848 | 0.0658 | |
| GSE26886 | PIP5K1A | 8394 | 207391_s_at | -0.1506 | 0.4092 | |
| GSE29001 | PIP5K1A | 8394 | 207391_s_at | -0.0407 | 0.8905 | |
| GSE38129 | PIP5K1A | 8394 | 207391_s_at | -0.1063 | 0.4097 | |
| GSE45670 | PIP5K1A | 8394 | 207391_s_at | -0.0850 | 0.5357 | |
| GSE53622 | PIP5K1A | 8394 | 162685 | -0.0035 | 0.9587 | |
| GSE53624 | PIP5K1A | 8394 | 162685 | 0.1960 | 0.0003 | |
| GSE63941 | PIP5K1A | 8394 | 207391_s_at | 1.7297 | 0.0003 | |
| GSE77861 | PIP5K1A | 8394 | 207391_s_at | 0.2490 | 0.1874 | |
| GSE97050 | PIP5K1A | 8394 | A_23_P23564 | 0.2231 | 0.4595 | |
| SRP007169 | PIP5K1A | 8394 | RNAseq | -0.4927 | 0.2175 | |
| SRP008496 | PIP5K1A | 8394 | RNAseq | -0.2128 | 0.3575 | |
| SRP064894 | PIP5K1A | 8394 | RNAseq | -0.5401 | 0.0246 | |
| SRP133303 | PIP5K1A | 8394 | RNAseq | 0.3524 | 0.0154 | |
| SRP159526 | PIP5K1A | 8394 | RNAseq | 0.7948 | 0.0086 | |
| SRP193095 | PIP5K1A | 8394 | RNAseq | 0.0817 | 0.3781 | |
| SRP219564 | PIP5K1A | 8394 | RNAseq | -0.0906 | 0.7586 | |
| TCGA | PIP5K1A | 8394 | RNAseq | 0.0536 | 0.2503 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PIP5K1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIP5K1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIP5K1A | 8394 | 14 | 0 | 16 | |
| GSE20123 | PIP5K1A | 8394 | 14 | 0 | 16 | |
| GSE43470 | PIP5K1A | 8394 | 6 | 1 | 36 | |
| GSE46452 | PIP5K1A | 8394 | 2 | 1 | 56 | |
| GSE47630 | PIP5K1A | 8394 | 14 | 0 | 26 | |
| GSE54993 | PIP5K1A | 8394 | 0 | 4 | 66 | |
| GSE54994 | PIP5K1A | 8394 | 15 | 0 | 38 | |
| GSE60625 | PIP5K1A | 8394 | 0 | 0 | 11 | |
| GSE74703 | PIP5K1A | 8394 | 6 | 1 | 29 | |
| GSE74704 | PIP5K1A | 8394 | 7 | 0 | 13 | |
| TCGA | PIP5K1A | 8394 | 37 | 2 | 57 |
Total number of gains: 115; Total number of losses: 9; Total Number of normals: 364.
Somatic mutations of PIP5K1A:
Generating mutation plots.
Highly correlated genes for PIP5K1A:
Showing top 20/51 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIP5K1A | VPS9D1-AS1 | 0.736467 | 3 | 0 | 3 |
| PIP5K1A | MDFI | 0.735635 | 3 | 0 | 3 |
| PIP5K1A | PDAP1 | 0.666955 | 3 | 0 | 3 |
| PIP5K1A | ITGB4 | 0.650724 | 3 | 0 | 3 |
| PIP5K1A | ZC3H18 | 0.642128 | 3 | 0 | 3 |
| PIP5K1A | CBX4 | 0.633888 | 4 | 0 | 3 |
| PIP5K1A | SERTAD3 | 0.62922 | 4 | 0 | 4 |
| PIP5K1A | FAAH | 0.616352 | 3 | 0 | 3 |
| PIP5K1A | C11orf42 | 0.610678 | 3 | 0 | 3 |
| PIP5K1A | FSCN1 | 0.609398 | 3 | 0 | 3 |
| PIP5K1A | HHLA3 | 0.608835 | 4 | 0 | 3 |
| PIP5K1A | PANX2 | 0.606404 | 3 | 0 | 3 |
| PIP5K1A | FUT1 | 0.60108 | 4 | 0 | 3 |
| PIP5K1A | AKT1 | 0.599163 | 4 | 0 | 3 |
| PIP5K1A | RTKN | 0.599075 | 4 | 0 | 3 |
| PIP5K1A | DLX6-AS1 | 0.59895 | 3 | 0 | 3 |
| PIP5K1A | PRMT1 | 0.598946 | 3 | 0 | 3 |
| PIP5K1A | COA6 | 0.594074 | 3 | 0 | 3 |
| PIP5K1A | SRC | 0.590842 | 3 | 0 | 3 |
| PIP5K1A | SLC39A1 | 0.590504 | 4 | 0 | 3 |
For details and further investigation, click here
