| Full name: chromobox 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 23466 | HGNC ID: HGNC:1556 | Ensembl Gene: ENSG00000183741 | OMIM ID: 617438 |
| Drug and gene relationship at DGIdb | |||
Expression of CBX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX6 | 23466 | 202047_s_at | 0.2387 | 0.7574 | |
| GSE20347 | CBX6 | 23466 | 202047_s_at | 1.0328 | 0.0000 | |
| GSE23400 | CBX6 | 23466 | 202048_s_at | 0.0149 | 0.8545 | |
| GSE26886 | CBX6 | 23466 | 202048_s_at | 0.6677 | 0.0083 | |
| GSE29001 | CBX6 | 23466 | 202048_s_at | 0.2970 | 0.4290 | |
| GSE38129 | CBX6 | 23466 | 202048_s_at | 0.0731 | 0.7930 | |
| GSE45670 | CBX6 | 23466 | 202048_s_at | 0.2803 | 0.2924 | |
| GSE53622 | CBX6 | 23466 | 26361 | 0.0752 | 0.6019 | |
| GSE53624 | CBX6 | 23466 | 26361 | 0.3396 | 0.0004 | |
| GSE63941 | CBX6 | 23466 | 202047_s_at | -0.0645 | 0.8986 | |
| GSE77861 | CBX6 | 23466 | 202048_s_at | 0.5277 | 0.0056 | |
| GSE97050 | CBX6 | 23466 | A_33_P3270485 | -0.5792 | 0.1882 | |
| SRP007169 | CBX6 | 23466 | RNAseq | 1.6172 | 0.0008 | |
| SRP008496 | CBX6 | 23466 | RNAseq | 1.8951 | 0.0000 | |
| SRP064894 | CBX6 | 23466 | RNAseq | 0.5641 | 0.1149 | |
| SRP133303 | CBX6 | 23466 | RNAseq | 0.0206 | 0.9218 | |
| SRP159526 | CBX6 | 23466 | RNAseq | 0.8846 | 0.0020 | |
| SRP193095 | CBX6 | 23466 | RNAseq | 1.7802 | 0.0000 | |
| SRP219564 | CBX6 | 23466 | RNAseq | -0.0232 | 0.9735 | |
| TCGA | CBX6 | 23466 | RNAseq | -0.2036 | 0.0692 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CBX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX6 | 23466 | 6 | 5 | 19 | |
| GSE20123 | CBX6 | 23466 | 6 | 4 | 20 | |
| GSE43470 | CBX6 | 23466 | 5 | 5 | 33 | |
| GSE46452 | CBX6 | 23466 | 32 | 2 | 25 | |
| GSE47630 | CBX6 | 23466 | 9 | 4 | 27 | |
| GSE54993 | CBX6 | 23466 | 3 | 6 | 61 | |
| GSE54994 | CBX6 | 23466 | 9 | 7 | 37 | |
| GSE60625 | CBX6 | 23466 | 5 | 0 | 6 | |
| GSE74703 | CBX6 | 23466 | 5 | 4 | 27 | |
| GSE74704 | CBX6 | 23466 | 3 | 2 | 15 | |
| TCGA | CBX6 | 23466 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of CBX6:
Generating mutation plots.
Highly correlated genes for CBX6:
Showing top 20/1197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX6 | USP20 | 0.820188 | 3 | 0 | 3 |
| CBX6 | FRMD3 | 0.750439 | 3 | 0 | 3 |
| CBX6 | TRIM28 | 0.747868 | 3 | 0 | 3 |
| CBX6 | GMPR | 0.735739 | 4 | 0 | 4 |
| CBX6 | CXorf40B | 0.733961 | 4 | 0 | 4 |
| CBX6 | EFTUD2 | 0.713301 | 3 | 0 | 3 |
| CBX6 | TXNIP | 0.712217 | 3 | 0 | 3 |
| CBX6 | CREB3 | 0.704686 | 4 | 0 | 3 |
| CBX6 | MRAS | 0.704383 | 5 | 0 | 5 |
| CBX6 | FOXC1 | 0.703766 | 3 | 0 | 3 |
| CBX6 | TSHZ1 | 0.703585 | 3 | 0 | 3 |
| CBX6 | ZCCHC7 | 0.701227 | 3 | 0 | 3 |
| CBX6 | SSBP4 | 0.700524 | 5 | 0 | 5 |
| CBX6 | PPP5C | 0.697136 | 4 | 0 | 4 |
| CBX6 | NONO | 0.696532 | 4 | 0 | 4 |
| CBX6 | SLC25A33 | 0.694532 | 3 | 0 | 3 |
| CBX6 | RNF34 | 0.692859 | 3 | 0 | 3 |
| CBX6 | MADD | 0.691102 | 4 | 0 | 4 |
| CBX6 | MYADM | 0.688469 | 3 | 0 | 3 |
| CBX6 | ENOX1 | 0.688038 | 5 | 0 | 4 |
For details and further investigation, click here
