PPP5C

 

Full name: protein phosphatase 5 catalytic subunit Alias Symbol: PP5
Type: protein-coding gene Cytoband: 19q13.32
Entrez ID: 5536 HGNC ID: HGNC:9322 Ensembl Gene: ENSG00000011485 OMIM ID: 600658
Drug and gene relationship at DGIdb

 

PPP5C involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway

 

Expression of PPP5C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP5C 5536 201979_s_at 0.3764 0.1926
GSE20347 PPP5C 5536 215705_at 0.0406 0.6780
GSE23400 PPP5C 5536 215705_at -0.0885 0.0432
GSE26886 PPP5C 5536 215705_at 0.1837 0.1714
GSE29001 PPP5C 5536 215705_at 0.1857 0.3752
GSE38129 PPP5C 5536 201979_s_at 0.2982 0.0001
GSE45670 PPP5C 5536 201979_s_at 0.1413 0.3071
GSE53622 PPP5C 5536 40015 0.1647 0.1052
GSE53624 PPP5C 5536 40015 0.2094 0.0073
GSE63941 PPP5C 5536 201979_s_at 2.0302 0.0000
GSE77861 PPP5C 5536 201979_s_at 0.3097 0.2038
GSE97050 PPP5C 5536 A_23_P153583 0.2805 0.2521
SRP007169 PPP5C 5536 RNAseq 0.3425 0.3083
SRP008496 PPP5C 5536 RNAseq 0.5823 0.0134
SRP064894 PPP5C 5536 RNAseq 0.4642 0.0029
SRP133303 PPP5C 5536 RNAseq 0.5029 0.0010
SRP159526 PPP5C 5536 RNAseq 0.7943 0.0017
SRP193095 PPP5C 5536 RNAseq 0.3928 0.0000
SRP219564 PPP5C 5536 RNAseq 0.4807 0.0607
TCGA PPP5C 5536 RNAseq 0.0186 0.6973

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PPP5C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP5C:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP5C 5536 4 5 21
GSE20123 PPP5C 5536 4 4 22
GSE43470 PPP5C 5536 3 11 29
GSE46452 PPP5C 5536 45 1 13
GSE47630 PPP5C 5536 8 7 25
GSE54993 PPP5C 5536 17 4 49
GSE54994 PPP5C 5536 5 13 35
GSE60625 PPP5C 5536 9 0 2
GSE74703 PPP5C 5536 3 7 26
GSE74704 PPP5C 5536 4 2 14
TCGA PPP5C 5536 15 15 66

Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.  

 

Somatic mutations of PPP5C:

 

Generating mutation plots.

 

Highly correlated genes for PPP5C:

 

Showing top 20/975 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP5CKLHDC30.8913303
PPP5CNFKBID0.822331303
PPP5CERI30.812027505
PPP5CMRPL380.8085505
PPP5COR2T330.79414303
PPP5CTTC40.792929303
PPP5CZNF4960.758318303
PPP5CSECTM10.753359303
PPP5CIL5RA0.75229303
PPP5CHELB0.749332303
PPP5COR2AT40.747829303
PPP5CFBXO160.745535303
PPP5CKRTAP12-20.74415303
PPP5CTMEM540.743459303
PPP5CSOX130.741442505
PPP5CCDK100.740319404
PPP5CPTGES20.738141605
PPP5CRHBDD20.736583403
PPP5CDNAJC190.736377303
PPP5CDEDD0.734898403

For details and further investigation, click here