CCND2

 

Full name: cyclin D2 Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.32
Entrez ID: 894 HGNC ID: HGNC:1583 Ensembl Gene: ENSG00000118971 OMIM ID: 123833
Drug and gene relationship at DGIdb
Screen Evidence:

 

CCND2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
hsa04917Prolactin signaling pathway
hsa05162Measles
hsa05166HTLV-I infection

 

Expression of CCND2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCND2 894 200953_s_at -1.3534 0.1159
GSE20347 CCND2 894 200953_s_at -0.6319 0.0889
GSE23400 CCND2 894 200953_s_at -0.3799 0.0768
GSE26886 CCND2 894 200953_s_at -0.5786 0.2497
GSE29001 CCND2 894 200953_s_at 0.0689 0.9317
GSE38129 CCND2 894 200953_s_at -1.0320 0.0008
GSE45670 CCND2 894 200953_s_at -0.2966 0.4952
GSE53622 CCND2 894 154986 -0.6306 0.0000
GSE53624 CCND2 894 154986 -0.6058 0.0000
GSE63941 CCND2 894 200953_s_at -2.5590 0.2814
GSE77861 CCND2 894 200953_s_at -0.1885 0.9003
GSE97050 CCND2 894 A_24_P278747 -0.6579 0.1186
SRP007169 CCND2 894 RNAseq 2.4179 0.0001
SRP008496 CCND2 894 RNAseq 2.4429 0.0000
SRP064894 CCND2 894 RNAseq -0.5629 0.0967
SRP133303 CCND2 894 RNAseq -0.2284 0.4742
SRP159526 CCND2 894 RNAseq -0.1141 0.8196
SRP193095 CCND2 894 RNAseq 0.1063 0.7155
SRP219564 CCND2 894 RNAseq -0.4853 0.3474
TCGA CCND2 894 RNAseq -0.2270 0.0867

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by CCND2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCND2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCND2 894 6 4 20
GSE20123 CCND2 894 6 4 20
GSE43470 CCND2 894 10 3 30
GSE46452 CCND2 894 10 1 48
GSE47630 CCND2 894 12 2 26
GSE54993 CCND2 894 1 10 59
GSE54994 CCND2 894 10 2 41
GSE60625 CCND2 894 0 1 10
GSE74703 CCND2 894 9 2 25
GSE74704 CCND2 894 4 2 14
TCGA CCND2 894 40 6 50

Total number of gains: 108; Total number of losses: 37; Total Number of normals: 343.  

 

Somatic mutations of CCND2:

 

Generating mutation plots.

 

Highly correlated genes for CCND2:

 

Showing top 20/457 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCND2MRVI10.7385404
CCND2EMCN0.721682303
CCND2SMPD10.719243303
CCND2MACROD20.718217303
CCND2CACNA1C0.692379303
CCND2RASSF30.688828303
CCND2HABP40.68231303
CCND2KIAA04080.679498303
CCND2PTGER30.679303404
CCND2PREX20.672631404
CCND2PPP3CB0.666147504
CCND2HOXA20.662916403
CCND2BAG30.659417403
CCND2LRRN4CL0.659371404
CCND2PHYHIPL0.657689303
CCND2NEXN0.656428404
CCND2PDLIM30.655721606
CCND2SLC2A120.655388303
CCND2SLIT30.653865403
CCND2MTRF1L0.649278303

For details and further investigation, click here