| Full name: PDZ and LIM domain 3 | Alias Symbol: ALP | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 27295 | HGNC ID: HGNC:20767 | Ensembl Gene: ENSG00000154553 | OMIM ID: 605889 |
| Drug and gene relationship at DGIdb | |||
Expression of PDLIM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDLIM3 | 27295 | 209621_s_at | -1.5392 | 0.3292 | |
| GSE20347 | PDLIM3 | 27295 | 209621_s_at | -0.3405 | 0.4353 | |
| GSE23400 | PDLIM3 | 27295 | 209621_s_at | -0.3343 | 0.2041 | |
| GSE26886 | PDLIM3 | 27295 | 209621_s_at | 1.3467 | 0.0121 | |
| GSE29001 | PDLIM3 | 27295 | 209621_s_at | -0.4889 | 0.4009 | |
| GSE38129 | PDLIM3 | 27295 | 209621_s_at | -0.6323 | 0.1804 | |
| GSE45670 | PDLIM3 | 27295 | 209621_s_at | -2.9149 | 0.0000 | |
| GSE53622 | PDLIM3 | 27295 | 26485 | -0.9702 | 0.0000 | |
| GSE53624 | PDLIM3 | 27295 | 26485 | -0.8556 | 0.0000 | |
| GSE63941 | PDLIM3 | 27295 | 209621_s_at | -1.6298 | 0.0361 | |
| GSE77861 | PDLIM3 | 27295 | 209621_s_at | 0.6919 | 0.0068 | |
| GSE97050 | PDLIM3 | 27295 | A_23_P110403 | -1.2623 | 0.1474 | |
| SRP007169 | PDLIM3 | 27295 | RNAseq | 4.9514 | 0.0000 | |
| SRP008496 | PDLIM3 | 27295 | RNAseq | 5.2346 | 0.0000 | |
| SRP064894 | PDLIM3 | 27295 | RNAseq | -0.3128 | 0.3336 | |
| SRP133303 | PDLIM3 | 27295 | RNAseq | -0.0395 | 0.9394 | |
| SRP159526 | PDLIM3 | 27295 | RNAseq | -0.8166 | 0.1187 | |
| SRP193095 | PDLIM3 | 27295 | RNAseq | 1.1923 | 0.0050 | |
| SRP219564 | PDLIM3 | 27295 | RNAseq | -0.8362 | 0.4468 | |
| TCGA | PDLIM3 | 27295 | RNAseq | -0.4153 | 0.0030 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by PDLIM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDLIM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDLIM3 | 27295 | 2 | 11 | 17 | |
| GSE20123 | PDLIM3 | 27295 | 2 | 11 | 17 | |
| GSE43470 | PDLIM3 | 27295 | 1 | 13 | 29 | |
| GSE46452 | PDLIM3 | 27295 | 1 | 36 | 22 | |
| GSE47630 | PDLIM3 | 27295 | 0 | 22 | 18 | |
| GSE54993 | PDLIM3 | 27295 | 10 | 0 | 60 | |
| GSE54994 | PDLIM3 | 27295 | 2 | 12 | 39 | |
| GSE60625 | PDLIM3 | 27295 | 0 | 0 | 11 | |
| GSE74703 | PDLIM3 | 27295 | 1 | 10 | 25 | |
| GSE74704 | PDLIM3 | 27295 | 1 | 5 | 14 | |
| TCGA | PDLIM3 | 27295 | 10 | 33 | 53 |
Total number of gains: 30; Total number of losses: 153; Total Number of normals: 305.
Somatic mutations of PDLIM3:
Generating mutation plots.
Highly correlated genes for PDLIM3:
Showing top 20/1124 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDLIM3 | MSRB3 | 0.868259 | 7 | 0 | 7 |
| PDLIM3 | ZEB1 | 0.851997 | 3 | 0 | 3 |
| PDLIM3 | TMEM47 | 0.842902 | 13 | 0 | 13 |
| PDLIM3 | ACTA2 | 0.835154 | 13 | 0 | 12 |
| PDLIM3 | TAGLN | 0.830571 | 12 | 0 | 11 |
| PDLIM3 | FERMT2 | 0.827827 | 13 | 0 | 13 |
| PDLIM3 | TPM1 | 0.817612 | 13 | 0 | 13 |
| PDLIM3 | MYLK | 0.799334 | 13 | 0 | 13 |
| PDLIM3 | JAM3 | 0.797503 | 13 | 0 | 13 |
| PDLIM3 | TPM2 | 0.795487 | 13 | 0 | 12 |
| PDLIM3 | CNN1 | 0.792158 | 11 | 0 | 11 |
| PDLIM3 | RASSF3 | 0.789954 | 4 | 0 | 4 |
| PDLIM3 | MRVI1 | 0.787203 | 7 | 0 | 6 |
| PDLIM3 | ACTG2 | 0.784759 | 13 | 0 | 13 |
| PDLIM3 | MRGPRF | 0.782103 | 8 | 0 | 8 |
| PDLIM3 | FHL1 | 0.78128 | 13 | 0 | 13 |
| PDLIM3 | FOXF1 | 0.778807 | 13 | 0 | 13 |
| PDLIM3 | LRFN5 | 0.777937 | 4 | 0 | 4 |
| PDLIM3 | RUNX1T1 | 0.776697 | 8 | 0 | 8 |
| PDLIM3 | FILIP1L | 0.771974 | 13 | 0 | 12 |
For details and further investigation, click here
