| Full name: CD40 ligand | Alias Symbol: CD40L|TRAP|gp39|hCD40L|CD154 | ||
| Type: protein-coding gene | Cytoband: Xq26.3 | ||
| Entrez ID: 959 | HGNC ID: HGNC:11935 | Ensembl Gene: ENSG00000102245 | OMIM ID: 300386 |
| Drug and gene relationship at DGIdb | |||
CD40LG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04660 | T cell receptor signaling pathway |
Expression of CD40LG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD40LG | 959 | 207892_at | -0.1146 | 0.6174 | |
| GSE20347 | CD40LG | 959 | 207892_at | -0.0374 | 0.6911 | |
| GSE23400 | CD40LG | 959 | 207892_at | -0.0933 | 0.0015 | |
| GSE26886 | CD40LG | 959 | 207892_at | -0.1044 | 0.2160 | |
| GSE29001 | CD40LG | 959 | 207892_at | -0.0208 | 0.9000 | |
| GSE38129 | CD40LG | 959 | 207892_at | -0.0727 | 0.3403 | |
| GSE45670 | CD40LG | 959 | 207892_at | -0.1220 | 0.1558 | |
| GSE53622 | CD40LG | 959 | 38930 | -1.2034 | 0.0000 | |
| GSE53624 | CD40LG | 959 | 38930 | -1.3139 | 0.0000 | |
| GSE63941 | CD40LG | 959 | 207892_at | 0.0067 | 0.9732 | |
| GSE77861 | CD40LG | 959 | 207892_at | -0.0682 | 0.4269 | |
| SRP133303 | CD40LG | 959 | RNAseq | -1.4584 | 0.0000 | |
| TCGA | CD40LG | 959 | RNAseq | -0.6451 | 0.2199 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CD40LG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD40LG:
No record found for this gene.
Somatic mutations of CD40LG:
Generating mutation plots.
Highly correlated genes for CD40LG:
Showing top 20/462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD40LG | ZNF831 | 0.708219 | 3 | 0 | 3 |
| CD40LG | PLD4 | 0.701961 | 3 | 0 | 3 |
| CD40LG | IL10RA | 0.700536 | 3 | 0 | 3 |
| CD40LG | CDH10 | 0.678537 | 5 | 0 | 5 |
| CD40LG | MS4A1 | 0.677302 | 5 | 0 | 4 |
| CD40LG | ITK | 0.674592 | 5 | 0 | 4 |
| CD40LG | IFT122 | 0.663774 | 3 | 0 | 3 |
| CD40LG | THEMIS | 0.655967 | 4 | 0 | 3 |
| CD40LG | GIMAP6 | 0.643266 | 3 | 0 | 3 |
| CD40LG | CCDC97 | 0.641051 | 3 | 0 | 3 |
| CD40LG | SLC5A4 | 0.639625 | 4 | 0 | 4 |
| CD40LG | OR10H3 | 0.639423 | 4 | 0 | 3 |
| CD40LG | C16orf54 | 0.638774 | 4 | 0 | 3 |
| CD40LG | MYL1 | 0.63148 | 3 | 0 | 3 |
| CD40LG | MAPK11 | 0.631362 | 3 | 0 | 3 |
| CD40LG | SHE | 0.627473 | 3 | 0 | 3 |
| CD40LG | TMPRSS5 | 0.624306 | 5 | 0 | 4 |
| CD40LG | DTHD1 | 0.624096 | 4 | 0 | 4 |
| CD40LG | SLC16A11 | 0.623547 | 3 | 0 | 3 |
| CD40LG | KIR3DL3 | 0.621834 | 4 | 0 | 4 |
For details and further investigation, click here
